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Single-shot dispersion-scan using a combination of prism and grating

The dispersion-scan technique (d-scan) is a well-established technique for the measurement of ultrashort laser pulses. While a single-shot version of d-scan is relatively easy to implement for sub-10 fs laser pulses, this becomes increasingly difficult as the pulse duration increases due to the need for a larger dispersion range, which scales quadratically with the Fourier transform limit (FTL). H

Changes in Apolipoprotein A1-Associated Proteomic Composition After Pioglitazone Treatment Versus Weight Loss

Insulin resistance (IR) contributes to atherogenic dyslipidemia and elevated ASCVD risk. Apolipoprotein A1 (ApoA1)-associated lipoproteins have diverse anti-atherogenic functions, but it is unclear whether IR drives adverse changes in their proteomic composition. We hypothesized that IR is associated with an atherogenic ApoA1 proteome and that insulin-sensitizing interventions would improve its co

Self-induced nonreciprocity from asymmetric photonic topological insulators

Photonic topological insulators and self-induced nonreciprocity based on nonlinear effects in asymmetric structures have garnered increased attention due to their potential applications in quantum information technologies and advanced photonic integrated circuits. In this study, we combine these two fields and present asymmetric photonic crystal designs based on all-dielectric checkerboard structu

Cryo-optical setup for wide-field microscopy and spectroscopy of luminescent nanomaterials

Studying photoluminescence (PL) is essential for understanding and engineering light-emitting nanomaterials. Heterogeneous samples, such as thin films and microstructures, require characterization of the spatial distribution of PL intensity, spectra, lifetimes, and photon correlations at the microscale under variable temperatures. Here we describe a cryo-optical setup for micro-PL imaging, spec

ACS Nano Journal Cover

Depiction of sinusoidal displacement in nanocrystal superlattices through a minimum of geometric shapes and contrasting colors. This cover pays homage to the Bauhaus movement, celebrating human-made craftsmanship, clarity, and accessibility in scientific design, and remains faithful to its fundamental principle: less is more.

“Oxygen tone” drives stage-specific OPC phenotypes for cell-based stroke therapy

Oligodendrocyte precursor cells (OPCs) display functional plasticity beyond myelination. Kuwata et al. explore how hypoxia shapes OPC features after ischemic stroke. Combining single-cell transcriptomics with in vivo and ex vivo models, they reveal oxygen-dependent OPC phenotypes promoting angiogenesis and remyelination, highlighting OPC versatility and potential for novel stroke cell therapies.

Aducanumab binding to Aβ1-42 fibrils alters dynamics of the N-terminal tail while preserving the fibril core

Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ1-42 fibrils remain unresolved. Using magic-angle spinning NMR, we show that binding of aducanumab preserves the overall architecture of the Aβ1-42 fibril core while inducing significant st

Long-term exposure to black carbon and incident asthma and chronic obstructive pulmonary disease in adults : The Danish Nurse Cohort

Background: Air pollution is a known risk factor for chronic respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). However, evidence regarding the role of black carbon (BC) remains mixed and sparse. This study aimed to examine the association of long-term exposure to air pollution, focusing on BC, with incident asthma and COPD in adults. Method: We followed 28,73

Proteomic analysis reveals angiogenesis-related plasma proteins associated with pre-eclampsia in SLE

Objective Delivery of a small for gestational age (SGA) infant is a common pregnancy complication among women with SLE. Although disease activity and autoantibodies such as anti-Smith and anti-ribonucleoprotein associate with SGA, underlying pathological mechanisms remain unclear and reliable predictors are lacking. To address this, we applied a proteomic approach to identify proteins associated w

Oscillometry findings in altered spirometry patterns and relationship to respiratory symptoms

Background Preserved ratio impaired spirometry (PRISm) and restrictive spirometry pattern (RSP) are associated with increased morbidity and mortality, but the underlying mechanisms are unclear. Impulse oscillometry (IOS) measures small airway function more sensitively than spirometry. We aim to study the prevalence of abnormal IOS findings in relation to three spirometry patterns (obstructive, PRI

1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification

BACKGROUND: Cardiovascular calcification is a significant predictor and contributor to cardiovascular diseases. Vascular smooth muscle cell (SMC)-derived extracellular vesicles (EVs) play a crucial role in microcalcification formation. EVs can originate from the endosomal system, and PIKFYVE (1-phosphatidylinositol 3-phosphate 5-kinase), a lipid kinase, plays a key role in endomembrane maturation.

Highly-destabilized ligand field excited states of iron carbene complexes and their relation to charge transfer state lifetimes

Lifetimes of photoexcited charge transfer (CT) states in transition metal chromophores are influenced by low-lying ligand field (LF) excited states, especially for 3d metal complexes. To manipulate interactions between LF and CT states, it is important to be able to control LF excited state energies using tunable synthetic variables. In this report, we use Fe 2p3d L3-edge resonant inelastic X-ray

Collisions without sight: head acceleration in blind football and implications for sport-related concussion

IntroductionSport-related concussion (SRC) is a pressing issue in Para sport, yet biomechanical mechanisms remain poorly understood. Athletes with visual impairment face elevated risks due to sport-specific demands, such as frequent collisions in blind football. This pilot study examined head acceleration responses in blind football players compared with non-disabled football players, and between

Multiexciton absorption cross sections of CdSe@CdS nanorods studied using pump–repump–probe spectroscopy

While the multiexciton dynamics in semiconductor nanocrystals is widely explored, to determine the absorption cross sections for multiexcitons of varying order is still a challenge. In this study, we performed pump–repump–probe transient absorption (ppp-TA) spectroscopic measurements on CdSe@CdS nanorods to gain insights into the absorption cross sections for multiexcitons. By tuning the pump–repu

Urinary tract infection during pregnancy and time relation to preterm birth—a Swedish observational study

Introduction: It is well known that urinary tract infection (UTI) during pregnancy is associated with preterm birth, but information about the risk of preterm birth depending on gestational week of infection is sparingly described in the literature. Material and Methods: An observational study based on data from Swedish registers including women giving birth 2014–2020 (n = 684 595). Pregnant women