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Context: The notion of insignificant prostate cancer (Ins-PCa) has progressively emerged in the past two decades. The clinical relevance of such a definition was based on the fact that low-grade, small-volume, and organ-confined prostate cancer (PCa) may be indolent and unlikely to progress to biologic significance in the absence of treatment. Objective: To review the definition of Ins-PCa, its in
Induced neurons (iNs) offer a novel source of human neurons that can be explored for applications of disease modelling, diagnostics, drug screening and cell replacement therapy. Here we present a protocol for highly efficient generation of functional iNs from fetal human fibroblasts, and also demonstrate the ability of these converted human iNs (hiNs) to survive transplantation and maintain their
Objective. To assess the impact of low-to-moderate risk prostate cancer on patients' quality of life (QoL) at diagnosis and within the first year of treatment. Subjects and Methods. Men (n = 672) aged 50-75 years with prostate cancer (Gleason score ≤7, PSA ≤20 ng/mL and clinical staging T1c-T2b) were enrolled in five European countries. Patients completed five questionnaires, including EORTC Quali
Context: Due to the complexity and challenging nature of radical prostatectomy (RP), it is likely that both short-and long-term outcomes strongly depend on the cumulative number of cases performed by the surgeon as well as by the hospital. Objective: To review systematically the association between hospital and surgeon volume and perioperative, oncologic, and functional outcomes after RP. Evidence
Context: MicroRNAs (miRNA) are noncoding RNAs that post- transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. Objective: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and r
A high-throughput method for the fabrication of ordered arrays of Au nanoparticles is presented. It is based on pulsed electrodeposition into porous anodic alumina templates. In contrast to many synthesis routes, it is cyanide-free, prior separation of the alumina template from the aluminium substrate is not required, and the use of contaminating surfactants/capping agents often found in colloidal
Introduction: Acute lower limb ischemia (ALI) is a life and limb threatening event often affecting patients with type 2 diabetes mellitus (T2DM). Little is known about how T2DM affects the risk of adverse events in patients revascularized for ALI. This study aimed to investigate if there were differences in major outcomes between ALI patients with and without T2DM. Methods: Between 2010 and 2014,
BackgroundMonogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of interventions in monogenic IR, stratified by genetic aetiology.MethodsSystematic review using PubMed, MEDLINE and Embase (1 January 1987 to 23 June 2021). Studies reporting individual-level effects of pharmacologic and/or surgical interventions in monogenic IR
Direct reprogramming of somatic cells into neurons offers a promising strategy for studying neurological disorders and developing cell-based therapies. This protocol describes the 3D direct reprogramming of human glial progenitor cells into dopaminergic neurons. It includes spheroid formation, lentiviral transduction, neuronal induction using doxycycline, and validation via gene expression and imm
Black carbon (BC), a major component of fine particulate matter (PM2.5), has been implicated in adverse neurodevelopmental outcomes, including autism spectrum disorders (ASD). While PM2.5 has been associated with increased ASD risk, the specific role of BC remains uncertain. This study aimed to assess prenatal exposure to BC and risk for ASD development in a low exposure setting, using a large, hi
Viruses are the most abundant and genetically diverse entities on Earth, yet the functions and evolution of most viral proteins remain poorly understood. Their rapid evolution often obscures evolutionary relationships, limiting the ability to assign functions using sequence-based methods. Although the conservation of protein fold can reveal deep homologies, viral proteins remain underrepresented i
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene. This leads to progressive loss of striatal neurons and motor-cognitive decline. While current gene-targeting approaches aiming at reducing somatic instability show promise – especially in case of early treatment – they cannot restore the already compromised neuronal circuitry at advanc
The structural integration of energy storage could play a pivotal role in designing more efficient, lightweight systems such as electric transport, internet of things (IoT) devices and autonomous systems. The current work focuses on the fabrication and characterization of novel multifunctional composites for sodium-ion structural batteries. A PEO-PVP polymer matrix with added InAs nanowires and gl
In this study we investigate risk management trade-offs by evaluating how key persons at workplaces with a potential for exposure to hexavalent chromium (Cr(VI)) reason about what is practically possible in terms of exposure reduction. While the included companies (N = 14) represented different types of processes and work-tasks, interviewees all identified that many types of hazards compete for at
1 M al m ö A rt A ca de m y 20 16 – 20 17 Masters of Fine Arts – Year 1 Bachelor of Fine Arts – Year 2 Bachelor of Fine Arts – Year 1 2 3 Master of Fine Arts Year 1 Sebastião Borges Axel Burendahl Nils Ekman Daniel Fleur Martine Flor Johanne Hestvold Maxime Hourani Alexandra Hunts Jonna Hägg Ellinor Lager Eli Maria Lundgaard Emil Palmsköld Joana Pereira Rasmus R Streith Joakim Sandqvist 4 MFA1 Her
https://www.khm.lu.se/en/sites/khm.lu.se.en/files/yearbook_digital_version_2017.pdf - 2026-05-30
Microsoft Word - Kaela final draft 1 LUND UNIVERSITY INTERNATIONAL MASTER’S PROGRAMME IN ENVIRONMENTAL STUDIES AND SUSTAINABILITY SCIENCE An Assessment of the Economic, Social and Environmental Impacts of the Mining Industry A Case Study of Copper Mining in Zambia AUTHOR: SUPERVISOR: Priscilla Kaela Kangwa Dr Ransom Lekunze, Copperbelt Museum Department of Social and Economic Geography Buteko Aven
https://www.lumes.lu.se/sites/lumes.lu.se/files/kaela_kangwa.pdf - 2026-05-30
Microsoft Word - schema utvc23 2020_2dec2019 .docx BIDS UTVC23 Lectures and Seminars 2020 4 21/1 10:15- 12:00 111 Introduction - Why development theory? Lec Andrés 22/1 10:15- 12:00 111 Why isn’t the whole world developed? Catching up and falling behind Lit: Ch 7 & 18 (Seligson), Ch 8 & 9 (Secondi) Lec Kamaruddin 23/1 10:15- 12:00 111 Development theory – the history of an idea Lit: Nayyar (web ar
https://www.keg.lu.se/en/sites/keg.lu.se.en/files/schema_utvc23_2020_2dec2019_.pdf - 2026-05-30
Lund University WINGS network at Lund University, Sweden WINGS, Lund University Lund University • Was started in 2003 by female Ph.D. students at the Department of Geology at Lund University Women IN Geological Sciences • Grass roots movement • Expanded during 2007 • All departments of the Faculty of Science • Obtained annual
https://www.wings.lu.se/sites/www.wings.lu.se/files/stepup2013_wings_at_stepuplu_johanna_stadmark.pdf - 2026-05-30
