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The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electro
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes encoding for ribosomal proteins. Recently, a case study reported a patient who became transfusion-independent in response to treatment with the amino acid L-leucine. Therefore, we have validated the therapeutic effect of L-leucine using our recently generated mouse model for RPS19-
In cold climates all user requirements for footwear (insulation, waterproof, vapour permeability, drying etc.) can’t be met easily due to their conflicting nature. Defining user conditions is important. Cold may be roughly divided into the three ranges (>+5; +5 to 10; < 10 °C). The choice of proper footwear may be based on this approach. It also reduces some of the conflicting user requirements. U
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The paper presents main conceptual distinctions underlying much of modern philosophical thinking about value. The introductory Section 1 is followed in Section 2 by an outline of the contrast between non-relational value (impersonal good, or good, period) and relational value (good for someone, or—more generally—good for some entity). In Section 3, the focus is on the distinction between final and
Designs for Extremely Large Telescopes (ELTs) are quite well advanced,but the requirements of instruments have had limited impact. Sinceprovision of a suitable environment for instruments is a critical aspectof all telescopes, we outline some well-known and some less-appreciatedchallenges of designing instruments for ELTs. A wide-field spectrometer(WFSPEC) with ~10 arcmin field-of-view, probably w
Abstract not available
A multi-lane traffic flow model based on stochastic noise driven dynamics is introduced and analyzed. The model employs conservative anisotropic Arrhenius spin-exchange (surfacediffusion) dynamics. We generate an asymmetric simple exclusion process to model vehicleinteractions. Vehicles react and advance based on the energy profile of their surrounding trafficthrough a novel look-ahead asymmetric
