Filtyp
In the era of stem cell research and regenerative medicine, understanding the regulatory networks that drive cellular reprogramming is fundamental. The study entitled ‘‘Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes’’ published in Stem Cell Reports sheds light on the remarkable versatility of Ascl1, a transcription factor known for its pivotal role in neu
Small-angle neutron scattering is used to study the exchange bias effect in Mn50Ni40Sn10. The martensitic transformation is found to be responsible for the nanometer-scale spin clusters (SCs) inside the low-temperature ferromagnetic (FM) martensite phase. The magnetic field dependences of the SCs and FM domains exhibit an asymmetry that characterizes the exchange bias. We find that the surface geo
The significance of neutron spin adiabaticity in the data analysis of polarized Grazing Incidence Small Angle Neutron Scattering (GISANS) is discussed, with the aim of minimizing the number of simulation parameters of complex magnetic models within the neutron scattering cross-section. We illustrate how an estimate of the neutron polarization direction and adiabaticity can be obtained by magnetic
We provide a detailed account of the origin and establishment of the Osteoarthritis Research Society International (OARSI) and celebrate its history from inception to the current day. We discuss the mission, vision and strategic objectives of OARSI and how these have developed and evolved over the last 3 decades. We celebrate the achievements of the society as we approach its 30th birthday, honor
Objective: To provide a summary of the translational gaps in musculoskeletal research as identified in the Mine the Gap workshop and propose possible solutions. Methods: The Mine the Gap online workshop was hosted on October 14th and 15th, 2020. Five international panels, each comprised of a clinician, clinical researcher and basic scientist, presented gaps and proposed solutions for the themes of
Negated forms have been shown to cause a higher processing cost for language comprehension in the form of higher error rates and longer processing times. Studies that tested prefixal negation (e.g. unhappy) found conflicting results as to whether these forms are processed as negated forms or as single lexical items without any processing cost (Hoosain, 1973; Sherman, 1976, 1973). The present study
Monolithic integration of InSb on Si could be a key enabler for future electronic and optoelectronic applications. In this work, we report the fabrication of InSb metal-semiconductor-metal photodetectors directly on Si using a CMOS-compatible process known as rapid melt growth. Fourier transform spectroscopy demonstrates a spectrally resolved photocurrent peak from a single crystalline InSb nanost
Importance: The effect of a physical property of irrigation fluid (at body vs room temperature) on recurrence rate in the evacuation of chronic subdural hematoma (cSDH) needs further study. Objective: To explore whether irrigation fluid temperature has an influence on cSDH recurrence. Design, Setting, and Participants: This was a multicenter randomized clinical trial performed between March 16, 20
Models for human brain-oriented research are often established on primary cultures from rodents, which fails to recapitulate cellular specificity and molecular cues of the human brain. Here we investigated whether neuronal cultures derived from human induced pluripotent stem cells (hiPSCs) feature key advantages compared with rodent primary cultures. Using calcium fluorescence imaging, we tracked
Objective: The association between knee injury and knee osteoarthritis (OA) is understudied relative to its importance, particularly in younger populations. This study was undertaken to examine the association of knee injury with radiographic features of knee OA in military officers, who have a physically demanding profession and high rates of knee injury. Methods: Participants were recruited in 2
MLL-rearrangements (MLL-r) are recurrent genetic events in acute myeloid leukemia (AML) and frequently associate with poor prognosis. In infants, MLL-r can be sufficient to drive transformation. However, despite the prenatal origin of MLL-r in these patients, congenital leukemia is very rare with transformation usually occurring postnatally. The influence of prenatal signals on leukemogenesis, suc
The increased interest in utilizing lignin as a feedstock to produce various aromatic compounds requires advanced chemical analysis methods to provide qualitative and quantitative characterization of lignin samples along different technology streamlines. However, due to the lack of commercially available chemical standards, routine quantification of industrially relevant lignin oligomers in comple
Due to their potential environmental risk, the abatement of organic micropollutants from wastewater has gained increasing attention in recent years. This thesis evaluates the use of ozone in Swedish wastewater treatment plants (WWTPs) and the incentives for full-scale implementation of organic micropollutant removal.This work is divided into two sections: the first segment comprises quantitative r
Immigrants from the Middle East to Sweden have a twice as high prevalence of type 2 diabetes (T2D) and obesity as native-born Swedes. Both obesity and T2D have been linked to increased incidence of cancer, cardiovascular disease (CVD) and all-cause mortality (ACM); however, data on differences between ethnicities are scarce. In a population-based cohort we aimed to study the impact of Middle Easte
The cleaning process of the bimetallic Pt3Sn(111) surface has been studied by means of low-energy electron microscopy (LEEM), microspot low-energy electron diffraction (μ-LEED), and X-ray photoemission electron microscopy (XPEEM). Different cleaning procedures, performed under ultra-high vacuum conditions (UHV), including sputtering with argon ions and repeated cycles of annealing up to 1500 K wer
Cervical pathology may contribute to residual problems after surgery for ulnar nerve compression. We aimed to evaluate the presence of pathological conditions in spinal cord and cervical spinal nerve roots in patients surgically treated for ulnar nerve compression at elbow. In a cohort of patients, surgically treated for ulnar nerve compression at elbow, magnetic resonance images (MRI; performed 3
The last decades have seen frequent calls for a more extended evolutionary synthesis (EES) that will supposedly overcome the limitations in the current evolutionary framework with its intellectual roots in the Modern Synthesis (MS). Some radical critics even want to entirely abandon the current evolutionary framework, claiming that the MS (often erroneously labelled “Neo-Darwinism”) is outdated, a
Vassiliki “Betty” Smocovitis has done a thorough and admirable job in highlighting the complex history the Modern Synthesis (MS) or the Evolutionary Synthesis (ES) as she prefers to call it. Her interesting contribution should hopefully increase awareness that the history of evolutionary biology is important even for researchers today who are mainly interested in solving practical questions of mor
Time-resolved analysis of photon cross-correlation function g(2)(τ) is applied to photoluminescence (PL) of individual submicrometer size MAPbI3 perovskite crystals. Surprisingly, an antibunching effect in the long-living tail of PL is observed, while the prompt PL obeys the photon statistics typical for a classical emitter. We propose that antibunched photons from the PL decay tail originate from
