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Parkinson disease (PD) is characterized by loss of the A9 nigral neurons that provide dopaminergic innervation to the striatum. This discovery led to the successful instigation of dopaminergic drug treatments in the 1960s, although these drugs were soon recognized to lose some of their efficacy and generate their own adverse effects over time. Despite the fact that PD is now known to have extensiv
Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women. Methods Individual data from 117 epidemiological studies, including 118 964 women with invasive b
Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinati
Early growth and differentiation of the pancreatic endoderm is regulated by soluble factors from the pancreatic mesenchyme. Previously, we demonstrated that N-cadherin-deficient mice lack a dorsal pancreas, due to a critical role of N-cadherin in dorsal pancreatic mesenchymal cell survival. Here, we show that restoring cardiac and circulatory function in N-cadherin null mice by cardiac-specific ex
There is an increasing consensus that individual adaptive capacities are critical to successfully adapt to climate change and achieve sustainable development. However, little is known about adaptive practices, particularly in developed countries. Against this background, this paper investigates the strategies used by Swedish citizens to adapt to (changing) climatic variability and extremes. It off
The liberalised electricity market in Sweden stresses the fact that the electricity companies must focus on customer satisfaction. Two major customer surveys concentrating on households’ requirements concerning the electricity bill have been carried out in spring 2002. The interest in energy management lies within the fact that the electricity bill can be used as a feedback instrument to influence
The people bordering the Arabian Gulf, the Mediterranean Sea and the Red Sea rely more and more on seawater desalination for safe water supply. Desalination has advantages and disadvantages which to a large extent depend on the region, location, technology, impact and amount of fresh water production. In this region, some 60% of all desalination capacity is installed. The three regions areas repre
Abstract not available
The described technical-economic model clarifies the influence of different production technological factors on the processing cost of a part. Influential factors can be weighted against each other, which leads to different production development scenarios and their effects on the processing cost can be studied. This implies a way to generate a basis of decision by which a company can base their p
Abstract not available
Efter HSVs utvärdering av CI- utbildningarna fick högskolorna ett tydligt uppdrag att vid uppföljningen redovisa hur hållbar utveckling kommer in i utbildningarna. I planeringsförutsättningarna för de 5-åriga civilingenjörsutbildningarna vid LTH finns kravet på examination av minst 6 hp inom området.
Combustion modeling based on a multi-step global reaction mechanism [1] is applied to CFD (Computational Fluid Dynamics) analysis of a scaled swirl-stabilized 4th generation premixed DLE (Dry Low Emission) burner for gas turbines. The flexi-fuel burner consists of a MAIN premixed flame, a premixed PILOT flame and a confined RPL (Rich Pilot Lean) flame. Both steady-state RANS (Reynolds Averaged Nav
Laser-induced incandescence (LII) is a versatile technique for quantitative soot measurements in flames and exhausts. When used for particle sizing, the time-resolved signals are analysed as these will show a decay rate dependent on the soot particle size. Such an analysis has traditionally been based on the assumption of isolated primary particles. However, soot particles in flames and exhausts a
Fibroblast growth factor (FGF) signaling controls axis formation during endoderm development. Studies in lower vertebrates have demonstrated that FGF2 primarily patterns the ventral foregut endoderm into liver and lung, whereas FGF4 exhibits broad anterior-posterior and left-right patterning activities. Furthermore, an inductive role of FGF2 during dorsal pancreas formation has been shown. However
The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias. Co-expression of WT1 and the fusion protein AML1-ETO in mice rapidly induces acute myeloid leukaemia (AML). Mechanisms behind expression of WT1, as well as consequences thereof, are still unclear. Here, we report that the fusion protein BCR/ABL1 increases expression of WT1 mRNA and protein via the phosphatidylinositol-3
