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Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers1. However, only a limited number of genetic risk loci ha

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Requirements and Use of In-service Information in an Engineering Redesign Task: Case Studies from the Aerospace Industry

This paper describes the research stimulated by a fundamental shift that is occurring in the manufacture and marketing of aero engines for commercial and defence purposes, away from the selling of products to the provision of services. This research was undertaken in an aerospace company, which designs and manufactures aero engines and also offers contracts, under which it remains responsible for

European Identity from Below : The Presence of Eurosymbols in Two European Capitals

Abstract in UndeterminedIdentity construction processes have been studied at the national level both from top-down (elite driven process) and from bottom-up (popular movements). In the context of European identity research, Billig's argument for "banal nationalism" has been transposed to the scale of the region by Cram under the name "banal europeanism". The present paper wants to test the process

Chemical Ecology in Aquatic Systems

In recent years it has become increasingly clear that chemical interactions play a fundamental role in aquatic habitats and have far-reaching evolutionary and ecological consequences. A plethora of studies have shown that aquatic organisms from most taxa and functional groups respond to minute concentrations of chemical substances released by other organisms. However, our knowledge of this “chemic

Doctoral education shapes the academy – what shapes doctoral education?

For universities all over the world, the strategic importance of doctoral education has increased over the last decades. Both locally and internationally we can observe growing activity in three interrelated areas of doctoral education: policy, knowledge formation and practice. Doctoral education is moving and has become a concern for the field of educational development. In a recent Swedish repor