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Background: Chronic non-healing wounds present a substantial economic burden to healthcare system; significant reductions in quality of life for those affected, and precede often serious events such as limp amputations or even premature deaths. This burden is also likely to increase with a larger proportion of elderly and increasing prevalence of life-style diseases such as obesity and diabetes. R
Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., Aβ42, total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Cl
Global warming and its effects on climate are of great concern. Climate change can affect buildings in different ways. Increased structural loads from wind and water, changes in energy need and decreased moisture durability of materials are some examples of the consequences. Future climate conditions are simulated by global climate models (GCMs). Downscaling by regional climate models (RCMs) provi
Crosslinked, cryostructured monoliths prepared from Lactobacillus reuteri cells were evaluated as potential immobilized whole-cell biocatalyst for conversion of glycerol, to potentially important chemicals for the biobased industry, i.e. 3-hydroxypropionaldehyde (3HPA), 3-hydroxypropionic acid (3HP) and 1,3-propanediol (1,3PDO). Glutaraldehyde, oxidized dextran and activated polyethyleneimine/modi
Background: Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE, used for the treatment of neuroendocrine tumours. The emission of gamma photons by 177Lu allows for imaging with SPECT (single photon emission computed tomography). One import
Pile heat exchangers are fast emerging as a potentially viable alternative to the more prevalent borehole heat exchangers for the provision of space heating and cooling. In the last decade or so, the use of geothermal piles has increased sharply in many countries including Belgium, China, Japan, Switzerland, the Netherlands, United Kingdom, and United States, among others. In Sweden, however, inte
A computational framework for modelling damage-induced softening in fibre-reinforced materials is presented. The main aspect of this framework is the proposed non-local gradient-enhanced continuum damage formulation. At the material level, the elastic constitutive behavior is defined by a hyperelastic functional including a volumetric and an isochoric contribution. The isochoric contribution is su
The instantaneous frequency (IF) of a non-stationary signal is usually estimated from a time-frequency distribution (TFD). The IF of heart rate variability (HRV) is an important parameter because the power in a frequency band around the IF can be used for the interpretation and analysis of the respiratory rate but also for a more accurate analysis of heart rate (HR) signals. In this study, we comp
Adaptation of crops to climate change has to be addressed locally due to the variability of soil, climate and the specific socio-economic settings influencing farm management decisions. Adaptation of rainfed cropping systems in the Mediterranean is especially challenging due to the projected decline in precipitation in the coming decades, which will increase the risk of droughts. Methods that can
Specimens of large fungi (mushrooms) were screened for mutagenic activity by the Salmonella/microsome assay, with strains TA98, TA2637 and TA100. Out of 48 species tested, 37 exhibited a significant but for the most part weak activity. The activity observed in the presence of S9 mix was typically between 0 and 50% of that without, and in no case was the activity increased in the presence of micros
Study Design Controlled laboratory study; cross-sectional. Background Postural control following anterior cruciate ligament reconstruction (ACLR) primarily has been investigated during static single-leg balance tasks. Little is known about dynamic postural control deficits post-ACLR. Objectives To compare dynamic postural control (bilaterally) in persons who have undergone ACLR and healthy control
The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and function, independently of their role in potentiating insulin secretion after a meal. Th
Respiratory proteins such as myoglobin and hemoglobin can, under oxidative conditions, form ferryl heme iron and protein-based free radicals. Ferryl myoglobin can safely be returned to the ferric oxidation state by electron donation from exogenous reductants via a mechanism that involves two distinct pathways. In addition to direct transfer between the electron donor and ferryl heme edge, there is
Invasive plants cause substantial economic and environmental damage throughout the world. However, eradication of most invasive species is impossible and, in some cases, undesirable. An alternative is to slow the spread of an invasive species, which can delay impacts or reduce their extent. We identify three main areas where models are used extensively in the study of plant spread and its manageme
We describe a beamline based on a plane-grating monochromator and an end-station designed for high resolution photoemission and photoabsorption spectroscopy on surfaces and interfaces using undulator radiation in the energy range 30 1500 eV. The general design of the beamline is based on a horizontally focusing pre-mirror, an SX-700 type of plane-grating monochromator and re-focusing optics of Kir
A strong low-energy shake-up satellite for CO adsorbed on Pd is observed. The occurrence of the satellite is established for the CO/1 ML Pd/Mo(110) system at a coverage where CO adsorbs exclusively on-top. Comparisons with CO adsorbed on Pd single-crystal surfaces and small supported Pd particles indicate that the strongly increased satellite intensity is due to the decreased CO-Pd interaction str
