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In some patients, graft-induced dyskinesia develops following intrastriatal transplantation of embryonic neural tissue for the treatment of Parkinson's disease. The mechanisms underlying these involuntary movements need to be clarified before this approach to clinical cell therapy can be developed further. We previously found that rats with 6-OHDA lesions, primed with L-DOPA treatment and that hav
A transmitter consisting of a voltage controlled oscillator (VCO) and power amplifier (PA) for the 400 MHz Medical Implanted Communication System band (MICS) was built in a standard 0.35-μm CMOS process. A push pull architecture was used for both the VCO and the PA. Two off-chip inductors were needed. The design was optimized for 400 μW output power at 3 V supply, which resulted in an efficiency o
Despite the spatially homogenous summer temperaturepattern in Fennoscandia, there are large spreadsamong the many existing reconstructions, resulting in anuncertainty in the timing and amplitude of past changes.Also, there has been a general bias towards northernmostFennoscandia. In an attempt to provide a more spatiallycoherent view of summer (June–August, JJA) temperaturevariability within the l
Inhibition of mitochondrial permeability transition (mPT) has emerged as a promising approach for neuroprotection and development of well-tolerated mPT inhibitors with favorable blood-brain barrier penetration is highly warranted. In a recent study, 28 clinically available drugs with a common heterocyclic structure were identified as mPT inhibitors e.g. trifluoperazine, promethazine and nortriptyl
Purpose. To assess rehabilitation, type of follow-up visits and outcome after bipolar hemiarthroplasty for femoral neck fracture. Method. Two hundred thirty-six consecutive patients with femoral neck fractures treated with hemiarthroplasty were followed for 30 months. Results. One hundred sixty-eight (71%) were women, 175 (74%) over 80 years old and 53 (22%) were demented. Of 150 patients with ava
Degradable starch microspheres (DSMs) are starch chains cross-linked with epichlorhydrin, forming glycerol-ether links. DSMs have been used for many years for temporary vascular occlusion and drug delivery in treatment of malignancies. They are also approved and used for topical haemostasis by absorbing excess fluid from the blood and concentrating endogenous coagulation factors, thereby facilitat
The c-KIT receptor tyrosine kinase mediates the cellular response to stem cell factor (SCF). Whereas c-KIT activity is important for the proliferation of hematopoietic cells, melanocytes and germ cells, uncontrolled c-KIT activity contributes to the growth of diverse human tumors. Suppressor of cytokine signaling 6 (SOCS6) is a member of the SOCS family of E3 ubiquitin ligases that can interact wi
A time-dependent mathematical model for the heat transfer in laser-induced hyperthermia has been developed. The model calculates the temperature distribution in surface-irradiated tissues. Good agreement was found between the predictions of the model and in vitro experimental results obtained for bovine liver irradiated with an expanded beam from a Nd:YAG laser. Surface evaporation of water was in
Following the implementation of advanced treatment procedures in radiotherapy, there is a need for dynamic dose verification in 3D. Gel dosimetry could potentially be used for such measurements. However, recently published data show that certain types of gels have a dose rate and fractionation dependence. The aim of this study was to investigate the feasibility of using a polymer gel dosimeter for
Combining the strengths of an advanced mathematical model of human physiology and a thermal manikin is a new paradigm for simulating thermal behaviour of humans. However, the forerunners of such adaptive manikins showed some substantial limitations. This project aimed to determine the opportunities and constraints of the existing thermal manikins when dynamically controlled by a mathematical model
Popular Abstract in Swedish Strålbehandling är en av de vanligaste behandlingarna mot cancer. Hälften av alla behandlingar syftar till att bota patienten från sjukdomen, men strålbehandling är även en mycket effektiv behandling för att lindra smärta och andra symptom för patienter med en obotlig cancer. Förberedelse inför strålbehandling är en komplicerad procedur, som innefattar många olika teknPreparation for radiotherapy is a complex procedure that involves many different technologies and groups of professionals. The rapid development and introduction of new technologies throughout the last decade have made it possible to deliver highly conformal, individually-shaped dose distributions with high accuracy. However, there is widespread concern that current quality assurance practices hav
Biological diversity encompasses the genetic diversity within each species, the range of species in a given ecosystem e.g. species diversity and the diversity of ecosystems across an entire region (Primack, 2000). At present 1 per cent of the world’s described species are threatened with extinction. The most pervasive and overriding threat is habitat loss and degradation due to human activity such
What kind of indispensable cognitive ability is needed for intelligence, sociability, communication, and technology to emerge on a habitable planet? My answer is simple: intersubjectivity. I stress the significance of intersubjectivity, of shared cognition, for extraterrestrial intelligence and interstellar communication, and argue that it is in fact crucial and indispensable for any successful in
This thesis is divided into two parts in which two different aspects of the Large Hadron Collider (LHC) Project are discussed. The first part describes the design of a transition radiation tracker (TRT) for the inner detector in ATLAS. In particular, the barrel part was studied in detail. The barrel TRT consists of 52 544 1.5-m-long proportional tubes (straws), parallel to the beam axis and each
Proton exchange membrane fuel cell (PEMFC) systems have been investigated as alternative power sources for the stationary and automotive applications. However, they do not appear on the market yet. One of the main reasons is the difficulty of the water/thermal management in the system. Several water recovery schemes have been proposed to overcome this difficulty and to simplify the system configur
