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Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 i

Context: Evidence-based software engineering (EBSE) provides a process for solving practical problems based on a rigorous research approach. The primary focus so far was on mapping and aggregating evidence through systematic reviews. Objectives: We extend existing work on evidence-based software engineering by using the EBSE process in an industrial case to help an organization to improve its auto

OBJECTIVE-Myocellular ATP synthesis (fATP) associates with insulin sensitivity in first-degree relatives of subjects with type 2 diabetes. Short-term endurance training can modify their fATP and insulin sensitivity. This study examines the effects of moderate long-term exercise using endurance or resistance training in this cohort. RESEARCH DESIGN AND METHODS-A randomized, parallel-group trial tes

Background: Observational studies have consistently associated obesity with colorectal cancer risk. Because both traits are genetically determined and share some metabolic biomarkers, we hypothesized that obesity-related polymorphisms could also influence the risk of developing colorectal cancer. Methods: We conducted a comprehensive population-based case-control study in 1,792 German colorectal c

Background & Purpose: Radiation therapy is an essential treatment for cancer patients with the ultimate goal to deliver radiation doses to the tumour with precision while minimizing exposure to surrounding healthy tissues. Treatment verification is crucial to ensure the accuracy of radiation delivery, for instance by measuring the radiation dose distribution. Among various dosimetry techniques

Denna uppsats syfte är att undersöka sätt att utveckla engagemang i och förståelse av klimatfrågan genom läsundervisning. Metoden jag har valt för att utreda det är aktionsforskning, genomförd på en gymnasieskola i södra Skåne. Där gjorde jag med sex elever en övning utifrån min valda sorts läsundervisning, lässtrategin dialogbaserad strategiundervisning, och en aktuell text om klimathotet. På så

I denna rapport föreslås en metod som syftar till att fördjupa förståelsen för identifiering av verifieringsbehovet, som rekommenderas i de svenska byggreglerna för analytisk dimensionering av byggnadstekniskt brandskydd. Syftet med denna rapport är att ge vägledning åt ingenjörer att noggrant ta reda på vilken effekt en förändring av en byggnads utformning har på byggnadens brandskyddssystem. Fö

Entreprenadavtal avser i allmänhet omfattande och långvariga arbeten som inbegriper flera olika parter. Det är relativt vanligt förekommande att parterna har olika åsikt gällande hur ett specifikt avtalsvillkor ska tolkas. Det finns ingen entreprenadrättslig lagstiftning. Företrädare för BKK, Byggandets Kontraktskommitté, har framförhandlat standardkontrakt. Standardkontrakten har en stark ställniConstruction contracts generally refer to extensive and long-term projects involving several different parties. It is relatively common for the parties to have different opinions regarding how a specific contractual term should be interpreted. There is no construction contract law in the area. Hereby representatives of the BKK, the Construction Contracts Committee, have negotiated standard contrac

My thesis ’’Responsibility to create sustainability – a concept analysis of responsibility in the sustainability reports of the Swedish fashion industry’’, investigates Hennes & Mauritz and Filippa Ks view of the concept responsibility in sustainability reports, be- fore and after the adoption of The Sustainable development goals. The purpose of this study is to uncover if the enterprises view

Syftet med denna studie vara att undersöka den högkänsliga personens subjektiva upplevelser av livet innan- och efter insikten om personlighetsdraget. Tillkommande frågeställningar som studerades, var även de positiva och negativa aspekterna av personlighetsdraget. Studiens metodologiska utgångspunkt var av den kvalitativa innehållsanalysen. Intervjuer hölls med sju deltagare som upplevde sig själThe purpose of this study was to examine the highly sensitives persons subjective experiences in life before- and after the knowledge about the personality character. Additional questions also studied the positive and negative aspects of the highly sensitive person. The studies methodological framework is based on the qualitative content analysis. The interviews where held with seven participants

I mars 2019 röstade EU-parlamentet igenom Direktivet om upphovsrätt på den digitala inre marknaden (”DSM-direktivet”) som medför förändringar i ansvarsstrukturen för upphovsrättsliga intrång på nätet. Direktivets kanske mest kontroversiella artikel är art 17 som behandlar ansvar för särskilda internetplattformar, så kallade ”onlineleverantörer av delningstjänster för innehåll” (”onlineleverantörerIn March 2019, the European Parliament adopted the Directive on Copyright in the Digital Single Market ("the DSM Directive") which implies changes in the liability regime of online copyright infringements. Perhaps the most controversial article in the directive is Art 17, which regulates liability on specific internet platforms, so-called "online content-sharing service providers” (

Våld i nära relationer och särskilt mäns våld mot kvinnor, anses idag utgöra ett allvarligt samhällsproblem. Det finns studier som visar att ungefär vart tionde barn i Sverige någon gång har upplevt våld mellan närstående vuxna. Detta kan få förödande konsekvenser för barnet i form av både fysiska och psykiska skador. Att låta barn bevittna våld eller andra brottsliga gärningar mellan närstående äViolence in close relationships and especially men’s violence against women, is today considered a social problem. There are studies showing that approximately every tenth child in Sweden has ever experienced violence between related adults. This can cause devastating consequences for a child, such as both physical and mental injuries. Letting children witness violence or other criminal acts betwe

This thesis aims to explore the meanings behind rural reading rooms (tushushi) in Yunnan Province, PRC. Rural reading rooms are small libraries attached to the village Party compound in Chinese villages; for the past decade 600 000 reading rooms have been established in administrative villages in China, and now benefit more than 1 billion farmers in what is arguably the world’s most important deve

Reliable information on land cover is required to assist and help in the decision-making process needed to face the environmental challenges society has to deal with due to climate change and other driving forces. Different methods can be used to gather this information but satellite earth observation techniques offer a suitable approach based on the coverage and type of data that are provided. Fe

GAs in Scattering Media Absorption Spectroscopy (GASMAS) is a technique to study free gas inside strongly scattering bulk-materials. GASMAS is successful in safely measuring oxygen in lungs of neonates, with low-power tuneable diode-laser spectroscopy at 760 nm. Because a similar need of lung monitoring exists in older patients, this work explores how GASMAS can be scaled up for larger geometries.