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Mitochondrial Effects of Common Cardiovascular Medications : The Good, the Bad and the Mixed

Mitochondria are central organelles in the homeostasis of the cardiovascular system via the integration of several physiological processes, such as ATP generation via oxidative phosphorylation, synthesis/exchange of metabolites, calcium sequestration, reactive oxygen species (ROS) production/buffering and control of cellular survival/death. Mitochondrial impairment has been widely recognized as a

Does Democratization Cause Redistribution? Evidence from Sweden and Brazil

This paper explores the relationship between democratization and economic redistribution using case study analysis applied to Sweden and Brazil. We find that democratization is intimately connected to redistribution through the welfare state, but as an event in itself is neither a necessary nor a sufficient cause of redistributive reforms. Democratization is not strictly necessary, because in antiThis paper explores the relationship between democratization and economic redistribution using case study analysis applied to Sweden and Brazil. We find that democratization is intimately connected to redistribution through the welfare state, but as an event in itself is neither a necessary nor a sufficient cause of redistributive reforms. Democratization is not strictly necessary, because in anti

Time-resolved photoluminescence studies of single interface wurtzite/zincblende heterostructured InP nanowires

The interface between wurtzite and zinc blende InP has been identified as type-II, where electrons gather on the zinc blende side and holes on the wurtzite side of the interface. The photoluminescence resulting from recombination across the interface is expected to be long-lived and to exhibit non-exponential decay of emission intensity after pulsed excitation. We verify this prediction using time

Enzyme encapsulation in nanostructured self-assembled structures : Toward biofunctional supramolecular assemblies

Enzymes have come into use for many new applications outside their natural biological environment, taking advantage of their high efficiency and selectivity as biocatalysts. Such new application often requires encapsulation to preserve the structure and activity of the enzyme, but also to regulate and control the activity. Here, we will discuss two types of encapsulation, soft matrices consisting

Fibril Charge Affects α-Synuclein Hydrogel Rheological Properties

In this paper, we have investigated the interactions between α-synuclein fibrils at different pH values and how this relates to hydrogel formation and gel properties. Using a combination of rheology, small-angle X-ray scattering, Raman spectroscopy, and cryo-transmission electron microscopy (cryo-TEM) experiments, we have been able to investigate the relationship between protein net charge, fibril

Is there a role for immunomodulatory drugs in the treatment of mantle cell lymphoma?

Although survival has improved in patients with mantle cell lymphoma (MCL) during the last two decades, thanks to intensified approach upfront and with anti-CD20 targeted treatment, the disease is still regarded as incurable and for the elderly/unfit patient population, there is need for more tolerable and effective treatment options. Immunomodulatory drugs (IMiDs) have demonstrated activity in MC

High crystalline quality homoepitaxial Si-doped β-Ga2O3(010) layers with reduced structural anisotropy grown by hot-wall MOCVD

A new growth approach, based on the hot-wall metalorganic chemical vapor deposition concept, is developed for high-quality homoepitaxial growth of Si-doped single-crystalline β -Ga 2 O 3 layers on (010)-oriented native substrates. Substrate annealing in argon atmosphere for 1 min at temperatures below 600 ° C is proposed for the formation of epi-ready surfaces as a cost-effective alternative to th

Artificial synaptic characteristics of PVA:ZnO nanocomposite memristive devices

Computational efficiency is significantly enhanced using artificial neural network-based computing. A two-terminal memristive device is a powerful electronic device that can mimic the behavior of a biological synapse in addition to storing information and performing logic operations. This work focuses on the fabrication of a memristive device that utilizes a resistive switching layer composed of p

The contributions of avoidable causes of death to gender gap in life expectancy and life disparity in the US and Canada: 2001–2019

ObjectivesThis study measures public health policies' and healthcare system's influence, by assessing the contributions of avoidable deaths, on the gender gaps in life expectancy and disparity (GGLD and GGLD, respectively) in the United States (US) and Canada from 2001 to 2019.MethodsTo estimate the GGLE and GGLD, we retrieved age- and sex-specific causes of death from the World Health Organizatio

Impact of Surgery for Primary Hyperparathyroidism

Primär hyperparathyroidism, pHPT, är en relativt vanlig endokrinologisk sjukdom som karaktäriseras av förhöjd utsöndring av bisköldkörtelhormon, PTH, i förhållande till kalciumnivån i blodet. Sjukdomen är vanligast hos äldre och kvinnor, och orsakas oftast av en godartad tumör i en bisköldkörtel (80–85% av fallen) eller mer diffus förstoring av flera bisköldkörtlar. Bisköldkörtlarnas fysiologiska

Electron effective mass in GaN revisited : New insights from terahertz and mid-infrared optical Hall effect

Electron effective mass is a fundamental material parameter defining the free charge carrier transport properties, but it is very challenging to be experimentally determined at high temperatures relevant to device operation. In this work, we obtain the electron effective mass parameters in a Si-doped GaN bulk substrate and epitaxial layers from terahertz (THz) and mid-infrared (MIR) optical Hall e

Majorana Qubits and Non-Abelian Physics in Quantum Dot-Based Minimal Kitaev Chains

The possibility of engineering artificial Kitaev chains in arrays of quantum dots coupled via narrow superconducting regions has emerged as an attractive way to overcome the disorder issues that complicate the realization and detection of topological superconducting phases in other platforms. Although a true topological phase would require long chains, a two-site chain realized in a double quantum

Potential interplay between tumor size and vitamin D receptor (VDR) polymorphisms in breast cancer prognosis : a prospective cohort study

Purpose: Vitamin D has some anticancer properties that may decrease breast cancer risk and improve prognosis. The aim was to investigate associations between four previously studied VDR SNPs (Taq1, Tru91, Bsm1, and Fok1) and prognosis in different groups of breast cancer patients. Methods: VDR genotyping of 1,017 breast cancer patients included 2002–2012 in Lund, Sweden, was performed using Oncoar

Supercurrent transport through 1e -periodic full-shell Coulomb islands

We experimentally investigate supercurrent through Coulomb islands, where island and leads are fabricated from semiconducting nanowires with fully surrounding superconducting shells. Applying flux along the wire yields a series of destructive Little-Parks lobes with reentrant supercurrent. We find Coulomb blockade with 2e peak spacing in the zeroth lobe and 1e average spacing, with regions of sign

Photoluminescence Studies of Polytype Heterostructured InP Nanostructures

The interface between two semiconductors significantly influences their optical and electronic properties. In contrast to traditional material heterostructures, polytype heterostructures between wurtzite (wz) and zincblende (zb) segments in homomaterial InP nanostructures exhibit sharp interfaces with minimal strain. The wz/zb interface of heterostructured InP has a type-II band alignment, which r

Defined shapes of carotid artery calcifications on panoramic radiographs correlate with specific signs of cardiovascular disease on ultrasound examination

Objective: The aim was to optimize diagnostics for carotid artery calcifications (CACs) on panoramic radiographs (PRs) to identify cardiovascular disease (CVD) by investigating how 4 defined CAC shapes are associated with ultrasound (US) findings indicating CVD. Study Design: The study included 414 participants (802 neck sides) from the Malmö Offspring Dental Study, examined with PRs. The PRs were

A popular public sphere: uncovering the making and memories The Swedish People’s Parks

The public sphere is a key geographic dimension of struggles for democracy, and democratic life more broadly. Yet, the nation of a public sphere is aften treated as a spatial metaphor for diffuse conversations. Drawing on critical geographies of social movements as makers of public places, we in this paper turn to the case of the early Swedish labor movements' several hundred so-called People's Pa

Lethal injuries in single stabs to the trunk – A study on homicides and suicides in Sweden

IntroductionHomicides using knives or other sharp objects are the most common type of homicide in Europe, and the second most common type of homicide worldwide. In contrast, suicides using sharp objects are rarer, constituting only a few per cent of all suicides in western countries. We investigated single stab injuries to the trunk in both homicides and suicides to assess differences in extent of

Risk of hand and forearm conditions due to vibrating hand-held tools exposure : a retrospective cohort study from Sweden

OBJECTIVES: The occurrence of hand and forearm disorders related to vibration exposure, adjusted for relevant background factors, is scarcely reported. We analysed the prevalence of such conditions in a large population cohort, stratified by sex, and associations with exposure to vibrating hand-held tools.DESIGN: This is a retrospective cohort study.SETTING: Individuals in the Malmö Diet and Cance