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Studies of molecular mechanisms of telomere maintenance in Naumovozyma castellii

POPULAR SCIENTIFIC SUMMARYI was on my way home, sitting on the bus. My tired eyes swept through the pages of the local newspaper and that was the moment I met Lisa. She had previously been diagnosed with cancer. She had recovered and was back to her daily life. Unfortunately the cancer has come back and it has spread to several organs. Lisa as a mother of two kids, as a wife, as a daughter, as a sTelomeres are special DNA-protein structures that protect ends of chromosomes from being recognized as double-strand breaks. Telomeres consist of tandemly repeated units of TG-rich DNA and associate with telomere-specific proteins.When a cell replicates its chromosomes, a certain piece of DNA is lost from chromosomal ends due to the ´´ end replication problem´´. This progressive shortening of telo

Natural Product Synthesis and Development of Novel Reaction Methodology

This thesis deals with the development of new reaction methodology for stereoselective synthesis, as well as total synthesis of natural products and investigations of the stereochemical outcome in the Mukaiyama aldol reaction. Chapter 2 describes efforts made towards the total synthesis of the oxindole natural products perophoramidine and the communesin. The first part of this chapter aims to de

From waste management to waste prevention

Closing implementation gaps through sustainable action nets This project deals with the principle formulated by the Swedish Environmental Protection Agency that sustainable waste policy should be oriented toward waste prevention and not only waste management. National authorities can steer through decisions and legislation, and introduce incitements and control mechanisms. But practical responsibi

https://www.ses.lu.se/fran-avfallshantering-till-avfallsforebyggande-0/waste-management-waste-prevention - 2026-05-09

Forskargruppen för systemisk skleros, Lund

Systemisk skleros, SSc, är en ovanlig reumatologisk sjukdom där immunologisk aktivering leder till kärlskada och fibros i hud och inre organ. Hälften av patienterna avlider av komplikationer från hjärta eller lungor, ofta fibros i lungor eller pulmonell arteriell hypertension (PAH). Projekten rör kartläggning av tidiga mekanismer kring patogenes och biomarkörer för tidig diagnos och monitorering aSystemic sclerosis, SSc, is a rare rheumatologic disease where immun activation leads to vascular damage and fibrosis in skin and internal organs. Half of the population will die from complications from heart or lungs, mostly lung fibrosis or pulmonary arterial hypertension (PAH). Our projects aim at early pathogenic mechanisms and biomarkers for early diagnosis and to monitor the disease and the

Antioxidants in Andean food and meals

Abstract The constant need to improve health and to prevent disease in Bolivia, especially in the Andean region with its extreme environmental conditions (high altitude and lower temperatures), motivated us to extend studies of antioxidant sources in foods and plants, since antioxidants are believed to have major health benefits. Spectrophotometric methods, such as ABTS (2, 2’- azinobis-3-ethyl

Baeyer-Villiger Monooxygenases from a Dietzia sp. - Enzyme Discovery, Characterization and Engineering

With the emergence of Green Chemistry, biocatalysis is becoming an important approach in many laboratory and industrial processes. Enzymes catalyse chemical reactions with high regio- and stereoselectivity at mild conditions and, most importantly, are able to form products that are not possible to obtain by conventional synthetic chemistry. Monooxygenases are a fascinating group of enzymes which o

Scattering approach to time-dependent charge and energy transport in mesoscopic conductors

This thesis aims to contribute to the field of time controlled charge and energy transport in mesoscopic systems. In Chapter 1, Chapter 2 and Chapter 3 a short review of the scattering matrix theory is presented, including both charge and energy transport, useful to understand the mathematical landscape used in Papers I, II, III and IV. Chapter 3 briefly presents the thermoelectric properties of m