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The sequence diversity of protein families is a result of the biophysical selection pressures that shaped their evolutionary history. Among the dominant pressures is selection for protein thermostability, which in itself is an attractive target in protein engineering because of its importance for various biopharmaceutical properties, the performance of industrial enzymes, and the ability to design
Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. The aim of this thesis was to analyze DNA methyla
The target group of our research is adults with limitations in participation and everyday life due to illness, injury or age. Our research is based on theories and models derived mainly within occupational therapy and occupational science, gerontology, rehabilitation, health economics, evaluation and implementation research. The research group is linked to the Centre for Ageing and Supportive
English is spoken in a multitude of accents all over the world. But these accents are not neutral. They are a source of stereotypes. For example, people who speak with a Birmingham accent are considered less intelligent and less suitable as a university lecturer than people speaking with a standard British accent. This thesis investigates the factors that influence how English children develop the
In this article I use autoethnographic method to assess two situations in which my kink identity and my non-monogamous identity clash with my role as a university teacher. Both identities are norm-breaking and stigmatized. They are coded as private in contrast to the professional ideal of the teacher. I ask how it affects me to keep part of my lived reality hidden and discuss what conflicts are ob
The textile industry’s linear business paradigm fuels excessive resource extraction and generate vast amounts of waste. Despite the EU Circular Economy Action Plan and growing industry awareness of these environmental concerns, many firms struggle to implement transformative Circular Business Models (CBMs) that provide a sustainable countermodel. Underlying socio-technical dynamics further amplify
Abstract Intensive land use in agriculture can lead to higher loss of biodiversity in soils and subsequently carbon due to tillage and application of pesticides and fertilizers. The microbial communities are pivotal to ecosystem processes in soil such as nutrient cycling, soil formation and plant productivity and thus are affected by land use. The main aim of this thesis is to understand the effe
In this article, we introduce and demonstrate the concept-metaphor of broken data. In doing so, we advance critical discussions of digital data by accounting for how data might be in processes of decay, making, repair, re-making and growth, which are inextricable from the ongoing forms of creativity that stem from everyday contingencies and improvisatory human activity. We build and demonstrate ou
This paper deals with limitations on control system performance due to load disturbances, measurement noise, actuator saturation and system dynamics. Simple problems which capture the essence of the problem are formulated and solved. The results make it possible to quickly explore a design problem for preliminary assessment before attempting to do massive computations. They are also useful ingredi
