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PURPOSE: To investigate estimated delivered dose distributions using weekly cone-beam computed tomography (CBCT) scans for pelvic organs at risk (OARs) in salvage radiotherapy (SRT) after radical prostatectomy. Furthermore, to compare them with the originally planned dose distributions and analyse associations with gastrointestinal (GI) and genitourinary (GU) side effects.METHODS: This study is pa

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A search for physics beyond the Standard Model inducing periodic signals in the dielectron and diphoton invariant mass spectra is presented using 139 fb−1 of s = 13 TeV pp collision data collected by the ATLAS experiment at the LHC. Novel search techniques based on continuous wavelet transforms are used to infer the frequency of periodic signals from the invariant mass spectra and neural network c

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BACKGROUND: After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year re

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Introduction: Immune checkpoint inhibitors (ICIs) have transformed lung cancer treatment, yet their effectiveness seem restricted to certain patient subsets. Current clinical stratification on the basis of programmed death ligand 1 (PD-L1) expression offers limited predictive value. Given the mechanism of action, directly detecting spatial programmed cell death protein 1 (PD1)–PD-L1 interactions m

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Multiconfiguration Dirac-Hartree-Fock (MCDHF) calculations and relativistic configuration interaction (RCI) calculations are performed for states of the 3s23p2, 3s3p3 and 3s23p3d configurations in the Si-like ions Ti IX - Ge XIX, Sr XXV, Zr XXVII and Mo XXIX. Valence and core-valence electron correlation effects are accounted for through large configuration state function expansions. Calculated en

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BACKGROUND: At present, selected patients with resectable colorectal peritoneal metastases (CRC-PM) are increasingly treated with a combination therapy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). The aim of this study was to investigate the current worldwide practice.METHODS: HIPEC experts from 19 countries were invited through the Peritoneal Surface Oncol

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A search for a heavy charged-boson resonance decaying into a charged lepton (electron or muon) and a neutrino is reported. A data sample of 139 fb-1 of proton-proton collisions at s=13 TeV collected with the ATLAS detector at the LHC during 2015-2018 is used in the search. The observed transverse mass distribution computed from the lepton and missing transverse momenta is consistent with the distr

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BACKGROUND: The effect of a treatment that includes frequent changes of the body position for infants with bronchiolitis has not been evaluated, although it is often used in Swedish hospitals. Because of this, a randomised control trial (RCT) has begun with the aim to evaluate this treatment, comparing the effect of an individualised physiotherapy intervention, a non-individualised intervention, a

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Long-term survival after childhood cancer often comes at the expense of late, adverse health conditions. However, survivorship care is frequently not available for adult survivors in Europe. The PanCareFollowUp Consortium therefore developed the PanCareFollowUp Care Intervention, an innovative person-centred survivorship care model based on experiences in the Netherlands. This paper describes the

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High-resolution resonant inelastic x-ray scattering (RIXS) and low-energy photoemission spectra of oxygen molecules have been measured for investigating the electronic structure of Rydberg states in the O 1s → σ∗ energy region. The electronic characteristics of each Rydberg state have been successfully observed, and new assignments are made for several states. The RIXS spectra clearly show that vi

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Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially affect microvascular function in SVDs. Aims: To test whether amlodipine has a beneficial effect on microvascular function when compared to either losartan or atenolol, and whether losartan has a beneficial effect when comp

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The objectives of this thesis are to find a common ground for business and environmental interests and to evaluate the potential of Environmental Management Systems (EMSs) as transition tools to lead towards a greener economic paradigm. For these purposes it was assessed, which implications EMSs have for the competitiveness of small and medium sized enterprises (SMEs) within the first three years

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Introduction: Dried blood spot sampling is an alternative way to conventional blood sampling that could potentially be a large benefit for certain patient groups. A good example is the transplanted patient group treated with the immunosuppressants everolimus and sirolimus. Background: The challenge is to develop a reliable quantification method based on this relatively novel sampling technique.

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The present thesis explores the requirement of the waiting period to grant family reunification to Third Country Nationals from the perspective of human rights law. It examines how this requirement, which currently forms a significant part of immigration policies within European member states, may impact TCNs' Right to family life under the European Convention on Human Rights (ECHR) and EU

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I slutet av 2014 hade 38 miljoner människor runt om i världen flytt sina hem till följd av krig, konflikt och våld. Att rädda liv och minska lidandet för dessa flyktingar är syftet med humanitärlogistik. Beredskap en nyckelroll i humanitära organisationer eftersom det är ett verktyg för att minska det negativa genomslaget av framtida händelser. En vanlig beredskapsåtgärd är att så kallad för-positAt the end of 2014, 38 million people around the world had fled their homes due to man-made disasters such as war, armed conflict and violence. To save the lives and alleviate the suffering of these refugees and displaced is the purpose of Humanitarian Logistics. Preparedness is of key importance in humanitarian organisations as it is a tool to reduce the impact of coming events. One common prepar

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The presumption of parental liability is an important tool for the Commission, enabling it to hold parent companies jointly and severally liable with their subsidiaries. Parent companies claim however, that they cannot rebut the presumption and are thus rendered strictly liable for their subsidiaries’ conduct. Due to the fact that parent companies repeatedly failed rebutting the presumption with e

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Lesbian, gay, and bisexual people continue to face discrimination and persecution in their daily lives, often from both the state and their communities. Where states do not provide for the basic human rights and physical security of their lesbian, gay, and bisexual citizens, many such citizens would flee their countries of origin in search of refuge in more hospitable countries. If other countries

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Denna uppsats syftar till att undersöka hur EU-rätten har påverkat svenska arbetstagarorganisationers möjligheter att använda sig utav stridsåtgärder och vilka effekter denna påverkan kan ha på den svenska arbetsmarknadsmodellen. För det första måste det sägas att EU-domstolens genom Laval och Viking har gjort det svårare för arbetstagarorganisationer att vidta stridsåtgärder då domstolen ansett aThis thesis has the aim of investigating how EU-law has affected the legal position regarding Swedish trade union’s possibilities of undertaking industrial actions. It also aims at determining whether the influence of EU-law on the right to undertake industrial actions has had any effects on the Swedish model. According to CJEU’s judgements in Laval and Viking it must be said that the possibilit

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This study aims to analyze the effects of competition on quality, efficiency, produced volume and gaming the system of specialized health care in Sweden, after implementation of the Freedom of Choice Act (LOV, Lagen om Vårdval). This is done by using data for specialized ophthalmology, which is a patient-elective diagnostic category. The motive behind the law, which established free entry for priv