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The International Society for Stem Cell Research (ISSCR) presents its 2016 Guidelines for Stem Cell Research and Clinical Translation (ISSCR, 2016). The 2016 guidelines reflect the revision and extension of two past sets of guidelines (ISSCR, 2006; ISSCR, 2008) to address new and emerging areas of stem cell discovery and application and evolving ethical, social, and policy challenges. These guidel
Phosphopeptides are often detected with low efficiency by MALDI MS analysis of peptide mixtures. In an effort to improve the phosphopeptide ion response in MALDI MS, we investigated the effects of adding low concentrations of organic and inorganic acids during peptide sample preparation in 2,5-dihydroxybenzoic acid (2,5-DHB) matrix. Phosphoric acid in combination with 2,5-DHB matrix significantly
We aim to introduce some new solutions in the studies involving the subjects who are not able to use spoken language, both animals and pre-verbal infants. Although our research focuses in general on the episodic memory introduced by Tulving in 1972, this paper is to present the case of Wistar rats and domestic cats.
Ascorbate (Asc) reductions of the oral anticancer platinum(IV) prodrugs cis,trans,cis-[PtCl2(OAc)2(cha)(NH3)] (JM216) and cis,trans,cis-[PtCl2(OCOC3H7)2(cha)(NH3)] (JM221) and of the isomers of JM216, viz.trans,cis,cis-[PtCl2(OAc)2(cha)(NH3)] (JM394) and trans,trans,trans-[PtCl2(OAc)2(cha)(NH3)] (JM576) (OAc = acetate, cha = cyclohexylamine) have been investigated in a 1.0 M aqueous perchlorate m
Reduction of the anticancer trans platinum(IV) prodrug JM335 by thiols in a moderately alkaline aqueous perchlorate medium is quite rapid and yields trans-[Pt(OH)2(c-C6H11NH2)(NH3)] as the reaction product. The mechanism of reduction involves reductive attack by thiol or thiolate on one of the mutually trans chloride ligands, leading to the formation of a chloride-bridged activated complex.The red
SynopsisOn the basis of kinetic studies of the manganese-catalyzed autoxidation of sulfite and thermodynamic data for iron−manganese redox processes and manganese(II) and -(III) protolysis equilibria, the catalytically active species in the autoxidation is concluded to be a mixed-valence oxo-bridged manganese(II,III) complex. Iron−manganese synergism and triggering of the chain reaction by small c
This thesis is dedicated to the design and analysis of superconductingelliptical cavities. Elliptical cavities play a central role in modern particle ac-celerators due to their high efficiency. After an introduction to the EuropeanSpallation Source project, the thesis goes through the design of the medium-βcavity. The RF design of the inner cell and end cell are presented in sequencein paper I . T
Objective: The aim of this study was to analyse the impact of maternal BMI at start of pregnancy and maternal weight gain during pregnancy on the risk of various diseases later in life. Methods: In a population-based cohort from southern Sweden, women with at least one delivery registered in the Swedish Medical Birth Register ten or more years before answering a health questionnaire were identifie
The aim was to perform a local study of risk factors and thrombophilia in mesenteric venous thrombosis (MVT), and to review the literature concerning thrombophilia testing in MVT. Patients hospitalized for surgical or medical treatment of MVT at our center 2000-2015. A systematic review of observational studies was performed. In the local study, the most frequently identified risk factor was Facto
This chapter sketches some of the societal dynamics that Gezi protests have expressed and the ways in which they constitute a significant departure from both the conceptualization and practice of politics in contemporary Turkey, through an interrogation of the politics of space that has occupied center stage in the protests.
The energy justice framework serves as an important decision-making tool in order to understand how different principles of justice can inform energy systems and policies. The realization of the urgency of providing modern energy technology and services particularly to rural areas has prompted both the Nepalese government and development institutions to focus on community-run renewable energy faci
Background: Rates of psychotic disorder are raised for many migrant groups. Understanding the role played by the social context in which they live may help explain why. This study investigates the effect of both neighbourhood ethnic density and urbanicity on the incidence of non-affective psychosis for migrant groups. Method: Population based cohort of all those born 1965 or later followed from th
Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to retreatment present continuing areas for research. The disease and its effective treatment are associa
In this work, a new copolymer synthesized in our laboratory is used as physically adsorbed coating for capillary electrophoresis (CE). The copolymer is composed of ethylpyrrolidine methacrylate (EPyM) and methylmethacrylate (MMA). The capillary coating is easily obtained by simply flushing into the tubing an EPyM/MMA solution. It is demonstrated that the composition of the EPyM/MMA copolymer toget
This study describes the design of degenerate primers and their use for synthesis of full-length avian influenza A neuramindase (NA). Each reaction was performed using either two forward primers and one reverse primer, or one forward primer and one reverse primer. Both primer combinations had comparable amplification efficiencies for all NA subtypes (1-9). A total of 115 virus strains, including b
Considering climate change and assessing its impacts is challenging due to dealing with large data sets and uncertainties. This paper discusses an approach for the impact assessment of climate change based on synthesizing weather data sets out of several climate scenarios, in a way to generalize the assessment despite of the existence of climate uncertainties. The is based on creating one-year wea
18F-dopa PET measuring aromatic l-amino acid decarboxylase activity is regarded as the gold standard for evaluating dopaminergic function in Parkinson's disease. Radioligands for dopamine transporters are also used in clinical trials and for confirming PD diagnosis. Currently, it is not clear which imaging marker is more reliable for assessing clinical severity and rate of progression. The objecti
