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The disruption of microtubule dynamics serves as a pivotal strategy for eliminating tumor cells, despite its accompanying toxicities affecting non-tumor cells. This study investigates the potential of selectively targeting γ-tubulin1 (TUBG1) as a therapeutic strategy in cancer treatment. By elucidating the TUBG1-E2F1-retinoblastoma protein (RB1) network, we introduce a novel compound, 4-(6-((3-Met
Background: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unc
Developing efficient and robust computational models is essential to improve our understanding of protein solution behavior. This becomes particularly important to tackle the high-concentration regime. In this context, the main challenge is to put forward coarse-grained descriptions able to reduce the level of detail, while retaining key features and relevant information. In this work, we develop
Exposure to extreme temperatures can negatively affect animal reproduction, by disrupting the ability of individuals to produce any offspring (fertility), or the number of offspring produced by fertile individuals (fecundity). This has important ecological consequences, because reproduction is the ultimate measure of population fitness: a reduction in reproductive output lowers the population grow
During the early modern period Swedish society was structured by a variety of hierarchies, and the principle of filial deference, or the obedience and recognition children–young or adult–were expected to show their parents, was more or less absolute. These ideas of family hierarchy influenced marriage laws and the formal rules of who was allowed to marry whom. During the 1700s the number of applic
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all
Theoretical approaches to learning in practice-based jazz improvisation contexts include situated learning and ecological perspectives. This article focuses on how interest-driven, self-sustaining jazz learning activities can be matched against the concepts of stolen knowledge (Brown & Duguid, 1996) and landscape of learning (Bjerstedt, 2014). Based on an extensive interview study with SwedishTheoretical approaches to learning in practice-based jazz improvisation contexts include situated learning and ecological perspectives. This article focuses on how interest-driven, self-sustaining jazz learning activities can be matched against the concepts of stolen knowledge (Brown & Duguid, 1996) and landscape of learning (Bjerstedt, 2014). Based on an extensive interview study with Swedish
Hypoxia and acidosis are inherent stress factors of the tumor microenvironment and have been linked to increased tumor aggressiveness and treatment resistance. Molecules involved in the adaptive mechanisms that drive stress-induced disease progression constitute interesting candidates of therapeutic intervention. Here, we provide evidence of a novel role of heparan sulfate proteoglycans (HSPG) in
BACKGROUND: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) is a group of autoimmune diseases, characterized by small vessel inflammation. Phagocytes such as neutrophils and monocytes are the main effector cells found around the inflamed vessel wall. Therefore, we wanted to investigate aspects of function and activation of these cells in patients with AAV.METHODS: Flow cytomet
RIKSAVTAL 1 RIKSAVTAL mellan Svensk Scenkonst och Teaterförbundet samt Akademikerförbunden avseende anställda vid offentligt finansierade teaterinstitutioner 2020.11.01 – 2023.03.31 2 Innehållsförteckning 1 Inledande bestämmelser…………………………………………………………………..5 1.1 Avtalets omfattning .................................................................................................... 5 1.2 Undantag ..
Compliance with (Quasi-) Judicial Decisions within the Regional African Human Rights System. Challenges and Opportunities Alejandro Fuentes Doctor of Law, Senior Researcher Patricia Iacob Research Assistant RESEARCH BRIEF Alejandro Fuentes Doctor of Law, Senior Researcher alejandro.fuentes@rwi.lu.se Patricia Iacob Research Assistant patricia.iacob@rwi.lu.se Disclaimer: The views and opinions expre
https://rwi.lu.se/app/uploads/2017/02/Compliancewithjudicialdecisions.pdf - 2026-06-21
Compliance with (Quasi-) Judicial Decisions within the Regional African Human Rights System. Challenges and Opportunities Alejandro Fuentes Doctor of Law, Senior Researcher Patricia Iacob Research Assistant RESEARCH BRIEF Alejandro Fuentes Doctor of Law, Senior Researcher alejandro.fuentes@rwi.lu.se Patricia Iacob Research Assistant patricia.iacob@rwi.lu.se Disclaimer: The views and opinions expre
https://rwi.lu.se/wp-content/uploads/2017/02/Compliancewithjudicialdecisions_2017-02-10.pdf - 2026-06-21
EOS-guide för prognos 1 EOS-Guide: Prognosuppgifter Innehåll Allmänt ........................................................................................................................ 2 Prognos personalförd ................................................................................................. 3 Översikt personal .....................................................................
https://www.ekonomiwebben.lu.se/sites/ekonomiwebben.lu.se/files/2026-05/eos-guide-for-prognos.pdf - 2026-06-21
Styrelseprotokoll 2019-11-20 Sida 1 av 4 STYRELSEPROTOKOLL Diarienummer Biologiska institutionen Datum 2019-11-20 Protokoll institutionsstyrelsen Närvaro Närvarande ledamöter Carin Jarl Sunesson, prefekt, ordförande, Marita Cohn, Nils Cronberg, Violeta Kaleskovska, Carina Rasmussen, Karin Rengefors, Johannes Rousk, Marcus Stensmyr, Tobias Uller, Niklas Wahlberg, Helena Westerdahl Frånvarande ledam
https://www.biologi.lu.se/internt/sites/biologi.lu.se.internt/files/2020-12/styrelseprotokoll20191120.pdf - 2026-06-21
Possible heterogeneity of initial pancreatic islet beta‐cell autoimmunity heralding type 1 diabetes Review-Symposium doi: 10.1111/joim.13648 Possible heterogeneity of initial pancreatic islet beta-cell autoimmunity heralding type 1 diabetes Åke Lernmark1 , Beena Akolkar2, William Hagopian3, Jeffrey Krischer4, Richard McIndoe5, Marian Rewers6, Jorma Toppari7, Kendra Vehik4, Anette-G. Ziegler8 & The
https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-11/151_2.pdf - 2026-06-21
Kursanalys för GEOB?4, Från lstid till nutid och Sveriges regionalgeologi, HT-l 2022 Kursen GEOB24 gavs för första gången höstterminen 2O!7 och består av fyra delar: Från istid till nutid - glaciation deglaciation och strandnivåförändringar (Del 1), Jordartskartering (Del 2), Fràn istid till nutid - mark, vegetation och fauna (Del 3) samt Sveriges regionalgeologi - berggrund och jordtäcke (Del 4).
https://www.geologi.lu.se/sites/geologi.lu.se/files/2023-01/GEOB24_2022_kursanalys_signerad.pdf - 2026-06-21
Understand, explain, improve – thematic collaborations 2020, Lund University Understand, explain, improve THEMATIC COLLABORATIONS | LUND UNIVERSITY EDITOR AND LAYOUT Bodil Malmström, Cooperation office Research, Collaboration and Innovation, Lund University TEXT Catrin Jakobsson, Noomi Egan, Jessika Sellergren, Bodil Malmström och Pia Romare. PHOTO Johan Bävman, Salar Haghighatafshar, Catrin Jakob
https://www.staff.lu.se/sites/staff.lu.se/files/2021-09/Understand%20explain%20improve%202020%20copy.pdf - 2026-06-21
Här får du som är doktorand vid naturvetenskapliga fakulteten övergripande information och stöd inom olika delar av din forskarutbildning. Genvägar till sidans innehåll: Översikt, villkor och stödStudieplanAvhandling och handledningCore Curriculum – kurspaket för generella kompetenserKurser för doktorander på institutionerForskarskolorInternationella möjligheterLicentiatseminarium och disputationE
https://www.naturvetenskap.lu.se/utbildning/dig-som-ar-doktorand - 2026-06-19
Finansiering av samarbeten Erasmus+ är EU-programmet för samverkan inom högre utbildning för perioden 2021–2027. Programmet syftar till att stödja människors utbildningsmässiga, yrkesmässiga och personliga utveckling genom livslångt lärande, både inom och utanför EU. Programmet bidrar till hållbar tillväxt, ökad sysselsättning och stärkt social sammanhållning, samt till innovation, europeisk ident
Purpose: To investigate how revealing the official secrets in different industries influence consumer trust. Methodology: Primary data were collected through a quantitative consumer survey measuring the impact of revealing an official secret on trust. This was complemented by secondary case analyses of Polestar and Kérastase, supported by relevant literature and industry sources to contextualize
