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OBJECTIVE: To examine the effect of using a mitt during shortened constraint-induced movement therapy for patients in the subacute phase after stroke. SUBJECTS: Twenty-four patients with stroke (mean age 57.6 (standard deviation (SD) 8.5) years; average 7 weeks post-stroke) with mild to moderate impaired hand function. METHODS: The patients were randomized to mitt use or no mitt use on the less af

This study focuses on the intrinsically disordered regulatory domain of p53 and the impact of post-translational modifications. Through fully atomistic explicit water molecular dynamics simulations, we show the wealth of information and detailed understanding that can be obtained by varying the number of phosphorylated amino acids and implementing a restriction in the conformational entropy of the

Professor, Docent, appointed Excellent Teaching Practitioner (ETP) Contact details Email: christine [dot] wamsler [at] LUCSUS [dot] lu [dot] se Phone: +46 46 222 80 80Organisation LUCSUS (Lund University Centre for Sustainability Studies) Visiting address: Josephson, Biskopsgatan 5, Lund Room number: Josephson, 219 Service point: 59 WebpageChristine Wamslers profile in Lund University research por

https://www.lucsus.lu.se/christine-wamsler - 2026-06-11

För att kunna följa försäkringsvillkor och förebygga brandrisk finns det en rutin för laddning och förvaring av litiumjonbatterier. Brand i litiumjonbatterier är ovanligt, men om det sker kan brandförloppet vara svårhanterligt och konsekvenserna kan bli mycket allvarliga. Genvägar till sidans innehåll:Rutinen i korthetLitiumjonbatterier – för verksamheten eller för privat bruk?Batterier för verksa

https://www.medarbetarwebben.lu.se/stod-och-verktyg/lokaler-och-parkering/forvaring-och-laddning-av-litiumjonbatterier - 2026-06-12

Adhesion is a key component of hematopoietic stem cell regulation mediating homing and retention to the niche in the bone marrow. Here, using an RNA interference screen, we identify cytohesin 1 (CYTH1) as a critical mediator of adhesive properties in primary human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Knockdown of CYTH1 disrupted adhesion of HSPCs to primary human mes

Acquisition of homozygous activating growth factor receptor mutations might accelerate cancer progression through a simple gene-dosage effect. Internal tandem duplications (ITDs) of FLT3 occur in approximately 25% cases of acute myeloid leukemia and induce ligand-independent constitutive signaling. Homozygous FLT3-ITDs confer an adverse prognosis and are frequently detected at relapse. Using a mou

Transcription factor (TF)-based reprogramming of somatic tissues holds great promise for regenerative medicine. Previously, we demonstrated that the TFs GATA2, GFI1B, and FOS convert mouse and human fibroblasts to hemogenic endothelial-like precursors that generate hematopoietic stem progenitor (HSPC)-like cells over time. This conversion is lacking in robustness both in yield and biological funct

The cellular and molecular mechanisms underlying specification of human hematopoietic stem cells (HSCs) remain elusive. Strategies to recapitulate human HSC emergence in vitro are required to overcome limitations in studying this complex developmental process. Here, we describe a protocol to generate hematopoietic stem and progenitor-like cells from human dermal fibroblasts employing a direct cell

Malignant melanoma is among the most aggressive skin cancers and it has among the highest metastatic potentials. Although surgery to remove the primary tumor is the gold standard treatment, once melanoma progresses and metastasizes to the lymph nodes and distal organs, i.e., metastatic melanoma (MM), the usual outcome is decreased survival. To improve survival rates and life span, advanced treatme

INTRODUCTION:Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis.METHODS:From a prospective population-based coh

Ectopic expression of transcription factors has been used to reprogram differentiated somatic cells toward pluripotency or to directly reprogram them to other somatic cell lineages. This concept has been explored in the context of regenerative medicine. Here, we set out to generate dendritic cells (DCs) capable of presenting antigens from mouse and human fibroblasts. By screening combinations of 1

BACKGROUND: Changes in glycosylation of serum proteins are common, and various glycoforms are being explored as biomarkers in cancer and inflammation. We recently showed that glycoforms detected by endogenous galectins not only provide potential biomarkers, but also have different functions when they encounter galectins in tissue cells. Now we have explored the use of a combination of two galectin

Globally, malignant melanoma shows a steady increase in the incidence among cancer diseases. Malignant melanoma represents a cancer type where currently no biomarker or diagnostics is available to identify disease stage, progression of disease or personalized medicine treatment. The aim of this study was to assess the tissue expression of alpha-synuclein, a protein implicated in several disease pr

Popular Abstract in Swedish Under sin livstid har Jorden genomlevt upprepade naturliga klimatförändringar. Genom att undersöka dessa klimatförändringar över tid och rum så kan vi öka vår förståelse för underliggande dynamik och mekanismer och därmed bättre förstå klimatsystemet. Två grundläggande förutsättningar för sådana undersökningar är trovärdiga rekonstruktioner av tidigare variationer i styThroughout its history Earth experienced a variety of natural climate changes. By investigating their spatial and temporal evolution we can increase the understanding of the mechanisms and dynamics underlying natural climate change and improve our general comprehension of the climate system. Prerequisites of these investigations are reliable reconstructions of past forcing variations as well as so

Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure. Recently, several protein kinase inhibitors and immune modifiers have shown promising clinical results but drug resistance in metastasized melanoma remains a major pr

OBJECTIVES: Prostate specific antigen (PSA) is a widely used and clinically valuable marker for prostate disease. In order to enable the development of new PSA assays and progress the understanding of the biology of PSA we have analyzed PSA in seminal plasma. Design and methods PSA in seminal plasma from men attending a fertility clinic and healthy controls was analyzed using SDS-PAGE, Western blo

Popular Abstract in Swedish Avhandlingen innehåller ett inledningskapitel följt av fyra separata studier. Studierna behandlar olika aspekter av humankapital, begåvning och immigration. I den första studien, Ability and Rates of Return to Schooling ? making use of the Swedish Enlistment Battery Test, används det svenska mönstringstestet för att skatta avkastningen på utbildningen för individer medThis thesis consists of an introductory chapter followed by four separate papers. The papers deal with various aspects of human capital, ability and migration. Using the Swedish Military Enlistment test, the first paper, Ability and Rates of Return to Schooling ? making use of the Swedish Enlistment Battery Test, estimates the return to schooling for individuals belonging to different parts of th

Every year, there are more than 2500 new international students coming to Lund University and starting their higher education path. A higher number of foreign students increased the international competitiveness of Lund University, but at the same time the international students had to face many problems for instance, culture shock and language barriers. In this report we focused on issues in teac

Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.

Self-renewal of hematopoietic stem cells (HSCs) and leukemia-initiating cells (LICs) has been proposed to be influenced by low oxygen tension (hypoxia). This signaling, related to the cellular localization inside the bone marrow niche and/or influenced by extrinsic factors, promotes the stabilization of hypoxia inducible factors (HIFs). Whether HIF-1α can be used as a therapeutic target in the tre