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Mutations in the BRCA1 and BRCA2 genes significantly contribute to hereditary breast cancer and ovarian cancer, but the phenotypic effect from different mutations is insufficiently recognized. We used a western Danish clinic-based cohort of 299 BRCA families to study the female cancer risk in mutation carriers and their untested first-degree relatives. Founder mutations were characterized and the
Identification of Lynch syndrome tumors is challenging. This relates particularly to MSH6-associated cases, which show reduced penetrance of colorectal cancer and a higher age at diagnosis. We recorded the clinical and morphologic features of 52 MSH6-associated colorectal cancers in comparison with MLH1/MSH2-mutant tumors and sporadic mismatch repair-deficient cancers. In the MSH6 subset, we confi
In the present study, we evaluated the cholesterol-lowering effects of different oat bran (OB) preparations, differing regarding their peak molecular weight (MWp) of beta-glucans (2348, 1311, 241, 56, 21 or < 10 kDa), in C57BL/6NCrl mice. The diets were designed to be atherogenic (0.8 % cholesterol and 0.1 % cholic acid), and they reflected the Western diet pattern (41 % energy fat). All OB prepar
Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian cancer (HBOC) syndrome and the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Genome-wide arr
OBJECTIVE: Insulin-like growth factor-1 (IGF-1) is essential for the pubertal growth spurt and for normal mammary gland development. IGF-1 increases premenopausal breast cancer risk. Oral contraceptives (OCs) decrease IGF-1 in most women. The endogenous estrogens and their metabolites also influence IGF-1 levels. Glutathione S-transferases (GSTs) are involved in estrogen metabolism. We aimed to st
Den här fallstudien undersöker hur Rädda Barnen arbetar opinionsbildande i sin kampanj för att få hem de svenska barnen med föräldrar som har IS-kopplingar från Syrien. Studien har gjorts i syfte att få förståelse för hur Rädda Barnen använder sig av medier för att bedriva sitt kampanjarbete och sätta sig själva och de frågor de bedriver på agendan. Vi har genomfört en studie där vi analyserat fle
Additiv tillverkning, eller 3D-printing, är på grund av sina många fördelar en ständigt ökande tillverkningsmetod. Designfriheten, det reducerade materialspillet, förkortad tid från ritning till färdig produkt och förmågan att kunna printa rörliga delar gör 3D-printing intressant för många olika användningsområden. Ett användningsområde där relativt lite forskning gjorts men som har ett ökat intreAdditive manufacturing, or 3D-printing, is due to its many advantages an increasingly used form of manufacturing. The design freedom, reduced material waste, shortened process from drawing to finished product, and the ability to print moving parts make it extremely interesting for many applications. One application where not much research has been done, but there is an increasing interest, is the
Titel: Länders kreditbetyg – samma idag som de en gång var? Datum för seminarium: 31/05/2018 Kurs: FEKH89 Författare: Johanna Carlsson, Cecilia Malmberg, Åke Sundvall Handledare: Anamaria Cociorva Nyckelord: Kreditbetyg på länder, WGI, makroekonomiska variabler, utveckling över tid, konservatism Syfte: Att undersöka vare sig Moody´s blivit mer konservativa gällande betygsättning av länder samt de Title: Sovereign Ratings – Same Today As They Once Were? Seminar date: 31/05/2018 Course: FEKH89 Authors: Johanna Carlsson, Cecilia Malmberg, Åke Sundvall Advisor: Anamaria Cociorva Key Words: Sovereign credit rating, WGI, macroeconomic variables, development over time, conservatism Purpose: To examine the conservatism of sovereign ratings according to Moody´s rating standards as well as the under
Uppsatsen “Förtroendeskapande online: Följares syn på influencers och politisk aktivism” är författad av Hanna Kjellgren och Olivia Avendaño på fortsättningskursen i Medie- och kommunikationsvetenskap vid Institutionen för kommunikation och medier vid Lunds universitet. I uppsatsen genomförs en publikstudie utifrån ett autenticitetsperspektiv om hur sociala medieanvändare uppfattar influencers pol
This thesis investigates the economic consequences of informal sanctions imposed by China on Norwegian salmon exports following the 2010 Nobel Peace Prize awarded to Chinese dissident Liu Xiaobo. Although no formal trade restrictions were announced, Norwegian salmon, a main export item, faced opaque import barriers that significantly disrupted trade flows. Using disaggregated product-level export
Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.
We explore cell heterogeneity during spontaneous and transcription-factor-driven commitment for network inference in hematopoiesis. Since individual genes display discrete OFF states or a distribution of ON levels, we compute and combine pairwise gene associations from binary and continuous components of gene expression in single cells. Ddit3 emerges as a regulatory node with positive linkage to e
Breast cancer (BC) is one of the leading causes of death among women worldwide. Immunostimulatory treatment has increasingly been used as adjuvant therapy in the last few years, in patients with melanoma and other cancer forms, often with an induction of autoimmunity as a consequence of a successful treatment. We aimed at investigating if coexisting autoimmune diseases (AD) or hypersensitivities (
Angiogenesis is one of the hallmarks of breast cancer. The status of angiogenesis is important in therapy choice. Spider telangiectasias (telangiectasias) may reflect an increased ability to form vessels. Our first aim was to identify patient and tumor characteristics associated with the occurrence of telangiectasias at the time of breast cancer diagnosis. The second aim was to study the overall s
The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compar
Background. Multidisciplinary team (MDT) conferences have been introduced into standard cancer care, though evidence that it benefits the patient is weak. We used the national Swedish Rectal Cancer Register to evaluate predictors for case discussion at a MDT conference and its impact on treatment. Material and methods. Of the 6760 patients diagnosed with rectal cancer in Sweden between 2007 and 20
Bilingualism has become increasingly prevalent globally, with about half of the world's population being bilingual by 2012. This growing trend has prompted cognitive research to explore the effects of bilingualism on executive functions. The Bilingual Advantage (BA) theory posits that bilingual individuals experience enhanced cognitive abilities due to their practice in managing multiple langu
I följande uppsats gör vi, genom att utgå från diskussionen om mediala diskurser om etisk konsumtion, en retorisk analys av företaget Sheins kampanj Sheincares, som är en kampanj i syfte att donera pengar till djurrättsorganisationer. Vi undersöker den tillhörande hashtagen #Sheincares på plattformen TikTok, som är ett av de sätt Shein marknadsför kampanjen. Shein har kommit att bli en av världens
Påföljden för mord ändrades år 2009 och en mer nyanserad påföljdsmodell infördes. Tidigare hade påföljden för mord antingen varit fängelse i 10 år eller på livstid, men nu infördes istället en modell, som gav domstolarna mer utrymme att utdöma tidsbestämda fängelsestraff mellan 10 och 18 år samt på livstid. Rättspraxis har förändrats under årens lopp, men genomgående har det uttalats att livstidThe penalty for murder was modified in 2009 and a more nuanced model of penalty was introduced. Earlier the penalty for murder either was prison being jailed for 10 years or life imprisonment, but now there instead was a model introduced that gave the courts more space to judge fixed term sentences between 10 and 18 years as well as for life imprisonment. Case law has been changed over the years,
aktivitetsrapport LUBIOFUELS_lowres.pdf LU Biofuels activity report 2009-20142 ACTIVITY REPORT 2009-2014 LU Biofuels activity report 2009-20141 Foreword by Gunnar Lidén and Henrik Stålbrand Aims Research for a Fossil Free Society Who We Are Network for Interdisciplinary Research Collaboration Paving the way for a Sustainable development Activities Stimulating ideas, projects and collaboration W
https://www.lubirc.lu.se/sv/sites/lubirc.lu.se.sv/files/aktivitetsrapport_lubiofuels.pdf - 2026-05-30
