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Context: Although magnetic resonance imaging (MRI) is emerging as the most commonly used imaging modality for prostate cancer (PCa) detection, treatment planning, and follow-up, its acceptance has not been uniform. Recently, great interest has been shown in multiparametric MRI, which combines anatomic T2-weighted (T2W) imaging with MR spectroscopic imaging (MRSI), dynamic contrast-enhanced MRI (DC
Background: Patient enrolment into clinical trials is based on oral information and informed consent, which includes an information sheet and a consent certificate. The written information should be complete, but at the same time risks being so complex that it may be questioned if a fully informed consent is possible to provide. We explored patient representatives' views and perceptions on the wri
In this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. Our first focus was on one of the most important biological risk factors in neuroblastoma -- amplification of the oncogene MYCN in the tumour cells. Because amplified MYCN typical
Context: The notion of insignificant prostate cancer (Ins-PCa) has progressively emerged in the past two decades. The clinical relevance of such a definition was based on the fact that low-grade, small-volume, and organ-confined prostate cancer (PCa) may be indolent and unlikely to progress to biologic significance in the absence of treatment. Objective: To review the definition of Ins-PCa, its in
Objective. To assess the impact of low-to-moderate risk prostate cancer on patients' quality of life (QoL) at diagnosis and within the first year of treatment. Subjects and Methods. Men (n = 672) aged 50-75 years with prostate cancer (Gleason score ≤7, PSA ≤20 ng/mL and clinical staging T1c-T2b) were enrolled in five European countries. Patients completed five questionnaires, including EORTC Quali
Context: Due to the complexity and challenging nature of radical prostatectomy (RP), it is likely that both short-and long-term outcomes strongly depend on the cumulative number of cases performed by the surgeon as well as by the hospital. Objective: To review systematically the association between hospital and surgeon volume and perioperative, oncologic, and functional outcomes after RP. Evidence
Context: MicroRNAs (miRNA) are noncoding RNAs that post- transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. Objective: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and r
Purpose: It is not yet possible to estimate the number of cases required for a beginner to become expert in laparoscopic radical prostatectomy. We estimated the learning curve of laparoscopic radical prostatectomy for positive surgical margins compared to a published learning curve for open radical prostatectomy. Materials and Methods: We reviewed records from 8,544 consecutive patients with prost
Popular Abstract in Swedish Dagens vårdsystem står inför många stora utmaningar. Många av dem är relaterade till komplexa vårdbehov hos den allt större andelen sköra äldre personer. Denna andel ökar samtidigt som många vårdorganisationer har krav på sig att minska kostnaderna. Dessa äldre personer har ofta flera sjukdomar samtidigt och de har vanligtvis kontakter med många olika vårdgivare, på fleThe overall aim of this thesis was to investigate healthcare utilisation patterns and to explore the effects of a case management intervention for frail older people on healthcare utilisation and costs in relation to utility. A further aim was to explore the older people’s and case managers’ experiences of the intervention. Study I was a quantitative study comprising ten age cohorts aged between 6
Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance of extrinsic regulators of HSC homeostasis. However, whereas extrinsic positive regulators of HSCs ha
Context: Newly discovered biomarkers ideally should prove clinical usefulness, provide additional detection, staging, and prognosis information to improve individual risk assessment, and potentially permit targeted cancer therapy. Objective: To review, display, and evaluate the current evidence regarding the biologic and analytic approach of urinary prostate cancer gene 3 (PCA3) in prostate cancer
Single cell gene expression assays have become a powerful tool with which to dissect heterogeneous populations. While methods and software exist to interrogate such data, what has been lacking is a unified solution combining analysis and visualisation which is also accessible and intuitive for use by non-bioinformaticians, as well as bioinformaticians.
Context: Prostate cancer (PCa) is one of the most common human malignancies and arises through genetic and epigenetic alterations. Epigenetic modifications include DNA methylation, histone modifications, and microRNAs (miRNA) and produce heritable changes in gene expression without altering the DNA coding sequence. Objective: To review progress in the understanding of PCa epigenetics and to focus
Due to their high aspect ratio and increased surface-to-foot-print area, arrays of vertical semiconductor nanowires are used in numerous biological applications, such as cell transfection and biosensing. Here we focus on two specific valuable biosensing approaches that, so far, have received relatively limited attention in terms of their potential capabilities: cellular mechanosensing and lightgui
Background: Brain metastases are associated with considerable negative effects on patients’ outcome in lung adenocarcinoma (LADC). Here, we investigated the proteomic landscape of primary LADCs and their corresponding brain metastases. Materials and methods: Proteomic profiling was conducted on 20 surgically resected primary and brain metastatic LADC samples via label-free shotgun proteomics. Afte
BACKGROUND: With the increasing number of breast cancer (BC) diagnosed as a second primary malignancy after a first primary non-breast cancer (BCa-2), it is unclear about the familial risk of BC among women with a first-degree relative (FDR, parents or siblings) affected by a BCa-2.METHODS: In this Swedish nationwide cohort study, 5315 women with a FDR affected by BCa-2 and 115,048 women with a FD
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Microsoft Word - Bilaga 8. Allmän studieplan, medicinsk vetenskap_2021_beslutad.doc Postadress Box 117, 221 00 LUND Telefon växel 046-222 00 00 Telefax 046-222 41 70 E-post info@med.lu.se Internet http://www.med.lu.se 1 1 Forskarutbildningsnämnden ALLMÄN STUDIEPLAN FÖR UTBILDNING PÅ FORSKARNIVÅ I MEDICINSK VETENSKAP Omfattning: 240 högskolepoäng Examen: Doktorsexamen Fastställd: 2018-06-11 Revider
Untitled © Johan Jönsson, 2008 Your Employeeship Questionnaire A survey of the relationships at your workplace © Johan Jönsson, 2008 Your Employeeship Questionnaire (YEQ) – self assessment Instructions: • Assume that you are engaged in the following 32 situations that are described. • The situations may differ in respect to how things are in your work team, department, and/or unit. Disregard this
https://www.psy.lu.se/en/sites/psy.lu.se.en/files/jb-yeq_full_version.pdf - 2026-05-29
PUBLIC PARTICIPATION IN THE PROCESS OF INTEGRA TED COAST AL ZONE MANAGEMENT MARIA JOSE MESEGUER PENALVA CI Marina 48, 5-5 08005 Barcelona, Spain E-mail: mariajo@pangea.org TABLE OF CONTENTS Summary Irist of Acronyms Introduction a) Objectives b) Scope c) Hypothesis Data Collection a) State of the Environment b) Spanish Legislation c) Integrated Coastal Zone Management d) Public Participation e) Lo
https://www.lumes.lu.se/sites/lumes.lu.se/files/penalva_maria_meseguer.pdf - 2026-05-29
