Sökresultat

OBJECTIVE: Insulin-like growth factor-1 (IGF-1) is essential for the pubertal growth spurt and for normal mammary gland development. IGF-1 increases premenopausal breast cancer risk. Oral contraceptives (OCs) decrease IGF-1 in most women. The endogenous estrogens and their metabolites also influence IGF-1 levels. Glutathione S-transferases (GSTs) are involved in estrogen metabolism. We aimed to st

DELLSON P., NILBERT M., BENDAHL P-O., MALMSTROM P. & CARLSSON C. (2010) European Journal of Cancer Care Towards optimised information about clinical trials; identification and validation of key issues in collaboration with cancer patient advocates Clinical trials are crucial to improve cancer treatment but recruitment is difficult. Optimised patient information has been recognised as a key iss

Popular Abstract in Swedish I avhandlingen redovisas undersökningar av näringsdynamiken hos fem olika lövträdsarter (ask, björk, bok, ek och lind) vilka jämförs med gran, som är ett mycket undersökt trädslag ur närings-synvinkel. Målsättningen med studierna var att klargöra de olika trädslagens näringstillstånd under likartade förhållanden, deras inverkan på och samspel med marken, samt deras näriThis thesis considers several important aspects of nutrient dynamics and allocation in adult stands of Swedish forest tree species (Quercus robur L., Tilia cordata Mill., Fraxinus excelsior L., Betula pendula Roth., Fagus sylvatica L. and Picea abies (L.) Karst) planted on the same soils. Differences between species in macro- (N, P, K, Ca, Mg, S), and micro- (B, Cu, Fe, Mn, Zn) nutrient levels in

The paper presents some ideas and modeling approaches that are feasible for the study of socio-technical systems. The emphasis in the paper is to discuss two approaches concerning modeling of social and technical systems, and how they can be integrated in order to assess the vulnerability of a socio-technical system. The Swedish railway system will serve as the example of a socio-technical system

In recent years it has become increasingly clear that chemical interactions play a fundamental role in aquatic habitats and have far-reaching evolutionary and ecological consequences. A plethora of studies have shown that aquatic organisms from most taxa and functional groups respond to minute concentrations of chemical substances released by other organisms. However, our knowledge of this “chemic

Reliable electrical power supply is a requirement for the modern society, therefore it is important to analyse the vulnerability of the electric power system. Network analysis has previously been used to analyse the vulnerability of electric transmission systems, however recent events in Sweden have shown that perturbations in distribution systems also can cause severe societal consequences. Thus,

Aging within the human hematopoietic system associates with various deficiencies and disease states, including anemia, myeloid neoplasms and reduced adaptive immune responses. Similar phenotypes are observed in mice and have been linked to alterations arising at the hematopoietic stem cell (HSC) level. Such an association is, however, less established in human hematopoiesis and prompted us here to

Introduction: Increased exhaled nitric oxide (NO) levels in asthma are suggested to be through inducible NO synthase (iNOS). The aim of this study was to investigate the expression of iNOS in bronchoalveolar lavage (BAL) cells and tissue from central and peripheral airways and compare it with the exhaled bronchial and alveolar NO levels in patients with asthma vs a control group. Methods: Thirty-t

Most animals, including aquatic crustacean zooplankton, perform strong avoidance movements when exposed to a threat, such as ultraviolet radiation (UVR). We here show that the genera Daphnia and Bosmina instantly adjust their vertical position in the water in accordance with the present UVR threat, i.e., seek refuge in deeper waters, whereas other taxa show less response to the threat. Moreover, D

Waiting times in cancer care is a patient safety risk that needs increased attention. Mechanisms and effects need to be clarified, waiting time statistics should be openly presented and evidence-based strategies should be implemented. Cancer patient pathways are implemented in Sweden during 2015–2018 and are expected to reduce waiting times for some patient groups, but cannot be expected to presen

Lynch syndrome caused by constitutional mismatch-repair defects is one of the most common hereditary cancer syndromes with a high risk for colorectal, endometrial, ovarian and urothelial cancer. Lynch syndrome is caused by mutations in the mismatch repair (MMR) genes i.e., MLH1, MSH2, MSH6 and PMS2. After 20 years of genetic counseling and genetic testing for Lynch syndrome, we have compiled the m

Objective: No large-scale nationwide study has determined the risk of ocular manifestations in patients with giant cell arteritis (GCA). The aim was to study the incidence and risk factors of ocular manifestations in patients with GCA in Sweden. Method: A national cohort was created by linking Swedish nationwide registers. GCA patients were identified from the Swedish Hospital Inpatient and Outpat

Background: Arm lymphedema after breast cancer surgery affects women both from physical and psychological points of view. Lymphedema leads to adipose tissue deposition. Liposuction and controlled compression therapy (CCT) reduces the lymphedema completely. Methods and Results: Sixty female patients with arm lymphedema were followed for a 1-year period after surgery. The 36-item short-form health s

Critical infrastructure systems must be both robust and resilient in order to ensure the functioning of society. To improve the performance of such systems, we often use risk and vulnerability analysis to nd and address system weaknesses. A critical component of such analyses is the ability to accurately determine the negative consequences of various types of failures in the system. Numerous mathe

The purpose was to elucidate the interplay between current smoking, anthropometric measurements, and endogenous hormone levels in women ≤ 40 years. Questionnaires on lifestyle and reproductive factors were completed by 269 healthy women from high-risk breast cancer families between 1996 and 2006 in Sweden. Blood samples for analyses of plasma testosterone, estradiol, androstenedione, sex hormone-b

Background:In Lynch syndrome, inherited mismatch repair (MMR) defects predispose to colorectal cancer and to a wide spectrum of extra-colorectal tumours. Utilising a cohort study design, we aimed to determine the risk of extra-colorectal cancer and to identify yet unrecognised tumour types.Methods:Data from 1624 Lynch syndrome mutation carriers in the Danish hereditary non-polyposis colorectal can

Passive integrated transponder (PIT)-tagging is commonly used in behavioural studies of fish, although long-term evaluations of effects from tagging under natural conditions are scarce. We PIT-tagged common bream Abramis brama, European perch Perca fluviatilis, pike Esox lucius and roach Rutilus rutilus, released them in their lakes of origin and recaptured them after 103–3269 days. Overall, tagge