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Neurogenin 2 (Ngn2) is a proneural gene involved in neuronal differentiation and subtype specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is expressed in a spatiotemporal pattern that correlates with the generation of mesencephalic dopaminergic (mesDA) neurons. We show here that lack of Ngn2 impairs the development of mesDA neurons, such that less than half of
The aim of this paper is to investigate the challenges associated with the industrial implementation of generative design systems. Though many studies have been aimed at validating either the technical feasibility or the usefulness of generative design systems, there is, however, a lack of research on the practical implementation and adaptation in industry. To that end, this paper presents two cas
På grund av ökad immigration till Sverige finns ett behov av att undersöka hur denna påverkar aktivitet, hälsa och meningsfullhet. Syftet med studien var att undersöka vilken eller vilka förändringar av aktivitetsmönstret som skett i Sverige i jämförelse med hemlandet och hur detta kan påverka kvinnliga flyktingars upplevelse av hälsa och meningsfullhet i vardagen. En kvalitativ metod med semistru
Aim: The aim of the study was to deepen the current knowledge of how patients with chronic obstructive pulmonary disease and long-term oxygen treatment think about and expect end-of-life. Design: A qualitative design was used. Methods: A purposeful sample of 19 patients with oxygen-dependent chronic obstructive pulmonary disease was obtained from the Swedish National Registry on Respiratory Failur
Popular Abstract in Swedish Avhandlingen utgörs av en retrospektiv studie av författarens pedagogiska och psykologiska praktik i Grundläggande Kommunal Vuxenutbildning i södra Sverige. Den grundläggande vuxenutbildningen genomförde i sin uppsökande verksamhet ett projekt vid Samhall AB, ett statsägt företag som producerar varor och tjänster och som har regeringens uppdrag att skapa meningsfulla ocThe present study is a retrospective investigation of the researcher’s pedagogic and psychological praxis in Municipal Adult Education in Sweden. At the time, the adult education unit in question had an outreaching project at Samhall, a state-owned company producing goods and services with an assignment from the government to provide meaningful work to employees with disabilities. A group of 23 wo
Title: Sing in Swedish! The purpose of this study is to find out how songs and singing could complement Swedish second language education. The method I have used to collect information is qualitative interviews with four persons with different professions: a teacher, a choirleader, a singing teacher and a medical doctor and a laryngologist. The study begins with a few thoughts about my interest in
The aim of this paper is to make an investigation of how authoritative conceptual framework about immigrants as a group is being constituted in the discourse regarding Swedish language for immigrants. I will also examine what connections there are to the overarching integration discourse. While doing this I try to establish the contrasting relationship between the ?Swedishness? and ?the Other?. My
Context: The questions of how many individuals and how much time to use for a single testing task are critical in software verification and validation. In software review and usability evaluation contexts, positive effects of using multiple individuals for a task have been found, but software testing has not been studied from this viewpoint. Objective: We study how adding individuals and imposing
The galectins are known to be able to recognize and cross-link beta-D-galactopyranoside-containing glycoconjugates as a result of presenting multiple binding sites. This review summarizes efforts in our group for the last ten years towards low-molecular weight chemically modified carbohydrate derivatives. In addition to providing an avenue for improved affinity and galectin-selectivity, we have fo
Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject
Over the past fifteen years, Hip Hop–based education has gained ground in academic literature, especially so by building on the educational tradition and gospel of Each One Teach One. A contribution to this scholarly discussion is the Scandinavian attempt to analytically tie Hip Hop education to perspectives on learning and pedagogy that traditionally derives from popular movements of the twentiet
The background to this article is an interest in what categorisations such as ‘persons with or without disability’ create in terms of inequality and stigma, and how categorisations can support the implementation of Universal Design (UD). The article aims to show how a shift in categorisation can lead to a shift in the conceptualisation of UD, from “inclusive” to “nonclusive” design, i.e., to desig
Microorganisms have unique biochemical mechanisms to inhibit the growth or kill other microorganisms in the same environment. Bacterial threat agents (BTA) are more effective than conventional weapons because of these characteristics, therefore, the development and production of biological weapons are still relevant. Early warning signals need to be obtained for fast and accurate detection of BTA
This paper addresses the influence of deteriorating structural system characteristics on the value of structural health monitoring (SHM) before its implementation. The value of SHM is calculated within a recently developed framework utilizing the Bayesian pre-posterior decision analysis modelling the structural system performance, the integrity management, the structural risks and the SHM informat
Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgi
