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Asthma patients who continue to experience symptoms despite taking regular inhaled corticosteroids represent a management challenge. Leukotrienes play a key role in asthma pathophysiology, and since pro-inflammatory leukotrienes are poorly suppressed by corticosteroids it seems rational to add a leukotriene receptor antagonist (LTRA) when a low to moderate dose of inhaled corticosteroids does not
The importance of the N-terminal region of human cystatin C or chicken cystatin for the kinetics of interactions of the inhibitors with four cysteine proteinases was characterized. The association rate constants for the binding of recombinant human cystatin C to papain, ficin, actinidin and recombinant rat cathepsin B were 1.1 x 10(7), 7.0 x 10(6), 2.4 x 10(6) and 1.4 x 10(6) M-1.s-1, whereas the
Sverige präglas idag av en stark urbaniseringstrend, där inflyttning främst sker till våra tre storstadsregioner. Ett problem som försvårar urbaniseringen är att utbudet av bostäder inte möter den stora efterfrågan som uppstått. Byggbar mark i centrala lägen betraktas dessutom ofta som fullt ianspråktagen. På så vis har en diskussion om möjligheter att effektivisera markanvändningen uppstått. DettToday, Sweden is characterized by a strong urbanisation trend, where occupation mainly takes place in our three metropolitan regions, Stockholm, Gothenburg and Malmö. A problem that complicates the urbanisation is the fact that supply does not meet the demand of housing, which has arisen in these areas. In addition, buildable land in central areas is often considered to be fully claimed. Thus, a d
The news media remains as one of the most important sources of societal uptake of climate change information. Its potential to covertly shape public perception and attitudes regarding climate change is therefore considerable but difficult to assess. This thesis underscores the discursive and cognitive role of metaphor in this dynamic by using a framework that combines the theory of conceptual meta
World politics consists of different international organizations and transnational actors which operate alongside with states. This thesis describes how international organizations and transnational actors are organized and their influence on world politics. These actors need to cooperate with states in order to have an impact, but they are not only powerless actors in world politics. The purpose
Den dag ett börsnoterat företag skall offentliggöra sin årsredovisning är alla externa intressenters strålkastare riktade mot just det företaget, vilket brukar medföra en viss uppståndelse. Scenariot brukar vara att VD:n berättar hur verksamheten har utvecklats, och i var mans hand återfinns en årsredovisning till utformningen likt ett tjockt magasin med tidsriktig design. Men vad hittar vi mellan
Technical assistance to public sector organisations is a much-debated topic and showcases a considerable size in contemporary international development assistance. Yet, the empirical evidence base on which factors contribute to the outcomes of projects within this field is surprisingly slim and diffuse. Particularly, the mechanisms through which different factors affect project outcomes remains un
A search for resonances in events with at least one isolated lepton (e or μ) and two jets is performed using 139 fb −1 of s = 13 TeV proton–proton collision data recorded by the ATLAS detector at the LHC. Deviations from a smoothly falling background hypothesis are tested in three- and four-body invariant mass distributions constructed from leptons and jets, including jets identified as originatin
This study aimed to test and validate a dual-time-window (DTW) protocol for 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK6240) dynamic PET imaging in experimental datasets acquired in human subjects. Methods: DTW protocols were tested and validated in datasets previously collected in 25 participants: 13 were cognitively normal, 10 had mild cognitive impairment, and 2
The current live attenuated vaccine against tuberculosis, BCG, poses a risk of disseminated infections in immunocompromised subjects. Therefore, in this study we compared the protective effect of a heat-killed bacille Calmette-Guerin (H-kBCG) vaccine given in a new adjuvant (Eurocine L3) with the protection provided by the conventional live attenuated BCG vaccine in mice (C57BL/6 and BALB/c) chall
Adverse environmental and social conditions early in life have a strong impact on health. They are major risk factors for mental diseases in adulthood and, in some cases, their effects can be transmitted across generations. The consequences of detrimental stress conditions on brain metabolism across generations are not well known. Using high-field (14.1 T) magnetic resonance spectroscopy, we inves
Background: In anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, antigen specificity varies between myeloperoxidase (MPO) and proteinase 3 (PR3). This has been reported to vary in relation to age, gender, geography and extrarenal manifestations. However, studies are difficult to compare as criteria for inclusion vary. The aim of this study was to investigate the relationsh
Kropp & straff blir ett konstnärligt träningsläger där deltagarna förbereder sig på ett fascistiskt maktövertagande. Lägret kommer att bestå av en rad olika scenarier, t ex ett polisförhör med förstärkta metoder eller tillvaron i total isolering. Dessa scenarier kommer gå att flytta och bytas ut. På detta sätt kan föreställningen hela tiden omstruktureras utifrån hur den utvecklas i mötet med
Allogeneic hematopoietic stem cell transplantation (HSCT) is beneficial for pediatric patients with relapsed or (very) high-risk acute lymphoblastic leukemia (ALL) in remission. A total of 1115 consecutive patients were included in the ALL SCT 2003 BFM study and the ALL SCT 2007 I-BFM study and were stratified according to relapse risk (standard versus high versus very high risk of relapse) and do
A search is presented for the pair production of heavy vector-like B quarks, primarily targeting B quark decays into a W boson and a top quark. The search is based on 36.1 fb−1 of pp collisions at s=13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Data are analysed in the lepton-plus-jets final state, characterised by a high-transverse-momentum isolated e
A search is presented for the pair production of heavy vector-like T quarks, primarily targeting the T quark decays to a W boson and a b-quark. The search is based on 36.1 fb−1 of pp collisions at s=13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Data are analysed in the lepton-plus-jets final state, including at least one b-tagged jet and a large-radius
Astrocytic glutamate (Glt) uptake keeps brain interstitial Glt levels low. Within the astrocytes Glt is converted to glutamine (Gln), which is released and reconverted to Glt in neurons. The Glt-Gln cycle is energy demanding and impaired energy metabolism has been suggested to cause low interstitial Gln/Glt ratios. Using microdialysis (MD) measurements from visually noninjured cortex in 33 neuroin
