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Reduced ectoparasite load, body mass and blood haemolysis in Eurasian kestrels (Falco tinnunculus) along an urban–rural gradient

Urbanisation is proceeding at an alarming rate which forces wildlife to either retreat from urban areas or cope with novel stressors linked to human presence and activities. For example, urban stressors like anthropogenic noise, artificial light at night and chemical pollution can have severe impacts on the physiology of wildlife (and humans), in particular the immune system and antioxidant defenc

Risk of Injuries around Diagnosis of Cervical Cancer and Its Precursor Lesions : A Nationwide Cohort Study in Sweden

BACKGROUND: Highly increased risk of injuries has been noted around the time of cancer diagnosis. Whether there is a similar increase in risk around the diagnosis of cervical cancer and its precursor lesions was unknown.METHODS: We performed a cohort study including 3,016,307 Swedish women that participated in cervical screening during 2001 to 2012. We calculated the incidence rates (IR) of hospit

Hypertension and Reproduction

Purpose of Review: Many aspects of reproduction have been associated with increased blood pressure and impaired glucose metabolism that reveals a subsequent increased risk of cardiovascular disease. The aim of this review is to assess reproductive life factors associated with an increased risk of hypertension and cardiovascular disease, e.g., early life programming, sexual, and reproductive health

Accelerating research on biological aging and mental health : Current challenges and future directions

Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential s

Arterial Input Functions and Tissue Response Curves in Dynamic Glucose-Enhanced (DGE) Imaging: Comparison Between glucoCEST and Blood Glucose Sampling in Humans

Dynamic glucose-enhanced (DGE) imaging uses chemical exchange saturation transfer magnetic resonance imaging to retrieve information about the microcirculation using infusion of a natural sugar (D-glucose). However, this new approach is not yet well understood with respect to the dynamic tissue response. DGE time curves for arteries, normal brain tissue, and cerebrospinal fluid (CSF) were analyzed

Time to awakening after cardiac arrest and the association with target temperature management

Aim: Target temperature management (TTM) at 32-36 °C is recommended in unconscious survivors of cardiac arrest. This study reports awakening in the TTM-trial. Our predefined hypotheses were that time until awakening correlates with long-term neurological outcome and is not affected by level of TTM. Methods: Post-hoc analysis of time until awakening after cardiac arrest, its association with long-t

Bra regler men dålig tillämpning – en enkätstudie om pressetik och publicitetsskador

Med en enkätstudie undersöks i detta projekt hur effektivt de berörda anser att de medieetiska systemen ger upprättelse. Här är det värt att nämna att vi då arbetet inleddes bad PO-kansliet om hjälp att distribuera vår enkät till alla dem som stod bakom framgångsrika anmälningar under 2015. På så sätt skulle enkäten kunna genomföras samtidigt som anonymiteten i PO-systemet kunde

FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes

The glutamate transporter 1 (GLT1) is upregulated during astrocyte development and maturation in vivo and is vital for astrocyte function. Yet it is expressed at low levels by most cultured astrocytes. We previously showed that maturation of human and mouse stem cell-derived astrocytes - including functional glutamate uptake - could be enhanced by fibroblast growth factor (FGF)1 or FGF2. Here, we

QREME – Quality requirements management model for supporting decision-making

[Context and motivation] Quality requirements (QRs) are inherently difficult to manage as they are often subjective, context-dependent and hard to fully grasp by various stakeholders. Furthermore, there are many sources that can provide input on important QRs and suitable levels. Responding timely to customer needs and realizing them in product portfolio and product scope decisions remain the main

Falls from Tractors in Older Age : Risky Behaviors in a Group of Swedish and Italian Farmers Over 65

The frequent mounting and dismounting the tractor required by many farming operations increases the risk of falls, particularly for older farmers. The present study explored the risk factors related to tractor ingress and egress in older farmers from two countries with a different tradition in terms of safety culture: Sweden and Italy. Eighteen male farmers aged 65 + (8 from Skåne region, southern

Knowledge Management: an Open Systems Approach

Nowadays, organizations pursue their aims in a context of distributed collaboration, creating a need not only for supporting ICT systems, but for a hu-man-centred focus in which individual and group sense-making and learning are supported by appropriate toolsets. We argue that development of such toolsets re-quires an open systems approach. This paper discusses one example: non-competitive benchma

Waterfowl in temperate eutrophic lakes - Interactions with macroinvertebrates, submerged vegetation and fish

Popular Abstract in Swedish I denna avhandling har jag fördjupat mig i de ekologiska sambanden mellan några av de mest påtagliga och kända organismerna i sjöar och dammar, nämligen sjöfåglar, undervattensväxter, smådjur (från och med nu kallade evertebrater, vilket betyder ryggradslösa djur), och i viss grad fisk. Bland sjöfåglarna (här avses främst änder, gäss, svanar och sothöns) finns det både The aim of this thesis was to explore some of the important links between waterfowl and the biota in shallow eutrophic lakes in temperate areas. Waterfowl depend on macroinvertebrates as sources of protein and calcium, which are essential for egg production and growth. Macroinvertebrates in turn depend on submerged vegetation for food and shelter. Increased density of vegetation thus leads to incr

ISO/OSI compliant network-on-chip implementation for CNN applications

The paper investigates the potential for a packet switching network for real-time image processing by a Cellular Neural Network (CNN) implemented on a Field-Programmable Gate-Array (FPGA). The implementation of a CNN requires several parameter restrictions with respect to the universal concept. For instance, the number representation and the cloning template are often confined to respectively 8 bi

Individual unmet needs for care: are they sensitive as outcome criterion for the effectiveness of mental health services interventions?

Background Mental health interventions should demonstrate an effect on patients' functioning as well as his/her needs, in particular on unmet needs whose assessment depends on the perspective of either the patient or the clinician. However, individual met and unmet needs appear to change over time, qualitatively and quantitatively, raising questions about their sensitivity to change and about the

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells

Insulin secretion is controlled by the beta cell's metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose stimulation in a membrane potential-independent fashion. Here, we demonstrate that exocytosis of insulin-containing secretory granules depends on phosphatidylinositol 4-kinase (PI 4-kinase) activity and that inhibition of this enzyme suppresse