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Chronic myeloid leukemia (CML) is genetically characterized by the Philadelphia (Ph) chromosome, formed through a reciprocal translocation between chromosomes 9 and 22 and giving rise to the constitutively active tyrosine kinase P210 BCR/ABL1. Therapeutic strategies aiming for a cure of CML will require full eradication of Ph chromosome-positive (Ph(+)) CML stem cells. Here we used gene-expression

The aim was to investigate the construct validity and internal consistency of the Swedish version of the Consumer Emergency Care Satisfaction Scale. The sample comprised 157 persons from an emergency department and an observation ward. The results showed satisfactory reliability, and an explorative factor analysis revealed 3 factors: Caring, Teaching, and Clinical Competence. The Swedish version o

The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and C

Wennick A, Hallström I, Lindgren B, Bolin K. Attained education and self-assessed health later in life when diagnosed with diabetes in childhood: a population-based study. Background: Previous studies have reported conflicting findings on academic achievement in children with type 1 diabetes, and generally lower self-assessed health status among respondents with diabetes. Objective: Thus, in this

Abstract in UndeterminedWe study the impact of the 1918 influenza pandemic on short- and medium-term economic performance in Sweden. The pandemic was one of the severest and deadliest pandemics in human history, but it has hitherto received only scant attention in the economic literature - despite representing an unparalleled labour supply shock. In this paper, we exploit seemingly exogenous varia

OBJECTIVE: Iron deficiency is a common but treatable comorbidity in chronic heart failure (CHF) that is associated with impaired health-related quality-of-life (HRQoL). This study evaluates the cost-effectiveness of the intravenous iron preparation ferric carboxymaltose (FCM) for the treatment of iron deficiency in CHF from a Swedish healthcare perspective. METHODS: A cost-effectiveness analysi

Röntgensjuksköterskors kompetens är en förutsättning för att garantera hög patientsäkerhet och vårdkvalité. Studiens syfte var att beskriva den kliniskt verksamma Radiological Technologists’ professionella kompetens inom diagnostisk radiologisk verksamhet i Japan. Metod var en enkätstudie med mätinstrumentet Radiographers’ Competence Scale som består av två domäner: “Nurse-initiated care” och “Tec

During the normal periods in absence of crisis, diversified firms without any excess cash as a whole, outperformed focused firms holding excess cash. During the Financial Crisis from mid 2007 to early 2009 on the other hand, focused firms holding excess cash outperformed less diversified firms and diversified firms as a group, where diversified firms with more than 2 different SIC codes performed

Since the 1970s, the practice of conscripting, enlisting or recruiting children into armed groups or forces has become increasingly common, and many children are used for various tasks in conflicts around the globe. Children are easily persuaded or forced into such armed groups or forces, and they suffer great harm from exposure to violence. Girls are generally recruited in the same manner as boys

Background: Few studies have investigated the subsequent rate of hospital and outpatient clinic utilization in those who receive continuing care and have documented frequent usage over one year. Such knowledge may be helpful in identifying those who would benefit from preventive interventions. The aim of this study was to investigate and compare the subsequent rate of hospital and outpatient clini

This study investigated the feasibility of targeting the free, unbound forms of prostate-specific antigen (fPSA) for in vivo imaging of prostate adenocarcinomas (PCa), as PSA is produced and secreted at abundance during every clinical stage and grade of PCa, including castration-resistant disease. We injected (125)I-labeled monoclonal antibody PSA30 (specific for an epitope uniquely accessible on

This study aims to predict saving behavior using Artificial Neural Network (ANN), XGBoost, and Support Vector Machine (SVM) algorithms. First, 25 variables were chosen from the original 217 questions asked by the National Financial Capability Well-Being Survey (2018) NFCS, using exploratory data analysis. K-means clustering was applied to determine the optimal number of saving classes (k=5) to inc

Före 2005 dömdes gärningspersoner som sexuellt utnyttjat en person som befunnit sig i ett hjälplöst tillstånd för sexuellt utnyttjande enligt 6 kap. 3 § Brottsbalken (BrB). Endast om det var gärningspersonen som själv hade medverkat till offrets hjälplösa tillstånd kunde denne åtalas för våldtäkt. Föranlett av ett stort missnöje och hätsk debatt i media trädde 2005 den nya sexualbrottslagstiftningPrior to 2005, offending persons involved in sexual exploitation of a person who found themselves in a vulnerable situation, were sentenced pursuant to Chapter 6 § 3 The Criminal Code. Only if the offending person had contributed to the victim's vulnerable situation, could he be prosecuted for rape. In 2005, the new sexual offenses law came into force, which was due to a great dissatisfaction

OBJECTIVE: To estimate the benefits and harms of interventions with and without surgery for musculoskeletal (MSK) conditions. DESIGN: Intervention systematic review with meta-analysis of randomized controlled trials (RCTs). LITERATURE SEARCH: MEDLINE, EMBASE, CINAHL, Web of Science, and CENTRAL, all up to January 7, 2021. STUDY SELECTION CRITERIA: RCTs (English, German, Danish, Swedish, and Norweg

Följande texter är tidigare publicerade som blogginlägg på Cybernormer.se samt digitalsociety.se och kretsar kring arbetslivets förändring i en digital kontext. Tillitsbegreppet är centralt här och texterna diskuterar exempelvis kontroll och övervakning - eller "employee monitoring" - kontra ökade frihetsgrader för anställda att styra över sina arbetstider.

Popular Abstract in Swedish Höftfraktur är en vanlig skada, som huvudsakligen drabbar äldre kvinnor, och oftast orsakas av ett ringa våld. Det är vanlig orsak till funktionsnedsättning, sjuklighet och dödlighet hos de äldre. Både incidensen (antal nya fall per antal innevånare och år) av höftfrakturer och det totala antalet har ökat de senaste årtiondena. Höftfrakturer medför stora kostnader för sHip fractures are a common cause of morbidity and mortality in elderly patients, with a high risk of functional impairment and institutionalization. The incidence and number of hip fractures have increased during the recent decades and hip fractures consume considerable health-care resources. The incidence of hip fractures in Malmö, Sweden, 1992–95, is described in Paper I. The annual incidence pe

Knowledge about food structures at different length scales is key for the continued development of sustainable, tasty and healthy foods. It is critical to control, model and predict the supramolecular architecture of foods along the whole value chain: from raw materials, to their changes during processing, all the way to how products form structures during consumption and digestion. Today, advance

BACKGROUND: Patients perceive high levels of weight prejudice, stigma, and discrimination within health systems, affecting their ability to manage their obesity and related chronic conditions. Scientific and patient obesity associations worldwide have prioritized the reduction of weight stigma to improve patient experiences in health systems and overall health outcomes. Since a significant proport

PurposeIn early breast cancer (BC), five conventional biomarkers—estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), Ki67, and Nottingham histologic grade (NHG)—are used to determine prognosis and treatment. We aimed to develop classifiers for these biomarkers that were based on tumor mRNA sequencing (RNA-seq), compare classification performance, a