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The ability to form biofilms is a crucial virulence trait for several microorganisms, including Klebsiella pneumoniae - a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex bacterial communities composed of one or more species encased in an extracellular matrix made of prot
Streptococcus pneumoniae is a pathogen responsible for high morbidity and mortality worldwide. The polysaccharide capsule confers protection against phagocytosis and influences many aspects of pneumococcal pathogenesis. The capsular polysaccharides (CPS) are highly immunogenic and exhibit great structural variability, with more than 100 serotypes described so far. Antimicrobial peptides (AMPs) ar
The impact of pilot flame operation on the combustion of pure methane and hydrogen-enriched methane (H2/CH4: 50/50 in vol%) fuels was investigated in a gas turbine model combustor under atmospheric conditions. The burner assembly was designed to mimic the geometry of an industrial burner, the Siemens DLE Burner, in which a concentric annular ring equipped with pilot flame burners is implemented in
How can ludic play frame and assist the participants' interactions in an immersive opera? The Consultant's Quest was developed as an artistic response to the idea and the challenge of integrating articulated game-playing as a both methodic and affective instrument in relation to operatic elements. Presented as a card-driven board game in connection to the operatic experience The Prophecies, The CoHow can ludic play frame and assist the participants' interactions in an immersive opera? The Consultant's Quest was developed as an artistic response to the idea and the challenge of integrating articulated game-playing as a both methodic and affective instrument in relation to operatic elements. Presented as a card-driven board game in connection to the operatic experience The Prophecies, The Co
As global food systems are currently presenting great challenges to our environment and our health, diverse new (sustainable) foods and possibilities to integrate these into consumers’ everyday diets are extensively studied. Due to industrialized, standardized food production, approaches from disciplines such as sensory science and consumer psychology play an important role in new product developm
We suggest a method that can be used for analysing an emergency response system. Both the literature and empirical findings indicate that response operations sometimes diverge from existing plans when adapting to an event and its consequences. The method, which aims at achieving a better understanding of emergency response management, adopts a systems perspective using various relationships that e
In making societal decisions concerning hazards with potentially disastrous consequences it is important to have soundly based knowledge of how people evaluate the seriousness of disasters. In the present study a group of students evaluated the seriousness of disasters described in terms of four basic attributes (and their ranges): number of fatalities (0-1000), number of serious injuries (0-4000)
This essay attempts to shed light on why aggressive ideas gain support within established western states. To do that it attempts to answer the question why the armed conflict against Iraq received such varied support during the first four months of 2003 within the United States, the United Kingdom, Australia, France and Spain. A comparative study indicates that the justifications for the armed con
OBJECTIVES: To analyze whether there is an association between neighborhood deprivation and cervical cancer morbidity and mortality, beyond individual level characteristics. DESIGN: The entire Swedish population aged 25 to 74, a total of 1.9million women, were followed from January 1, 1990, until hospital admission due to cervical cancer during the study period, or the end of the study on Dece
Objective: Using Swedish nationwide registry data, the authors investigated genetic and environmental risk factors in the etiology of drug abuse by twin sibling modeling. The authors followed up with epidemiological analyses to identify shared environmental influences on drug abuse. Method: Drug abuse was defined using public medical, legal, or pharmacy records. Twin and sibling pairs were obtaine
Environmental exposures, including smoking, hormone-related factors, and metabolic factors, have been implicated in the etiology of rheumatoid arthritis (RA). A previous study has indicated that blood lipid levels may influence the development of RA. The objective of this study was to investigate the impact of serum total cholesterol and triglycerides on the risk of RA in a prospective study.
This article stresses the significance of recognising interdependencies between factors determining disaster risk in any attempts to integrate disaster risk reduction in international development cooperation. It bases its arguments on the case studies of four past projects in Sri Lanka and Tajikistan, which are scrutinised using a theoretical framework based on systems approaches. It appears that
We present a detailed comparison of ectopic ossification (EO) found in tendons of biglycan (Bgn), fibromodulin (Fmod) single and double Bgn/Fmod-deficient (DKO) mice with aging. At 3 months, Fmod KO, Bgn KO and DKO displayed torn cruciate ligaments and EO in their quadriceps tendon, menisci and cruciate and patellar ligaments. The phenotype was the least severe in the Fmod KO, intermediate in the
Research on the role of nutrition in type 2 diabetes has largely focused on macro/micronutrient composition and dietary fiber intake, while fewer studies have tested the effects of differing food choice. Some observational studies and short-term intervention studies suggest that a food pattern mimicking the diet with which humans evolved positively influences glucose control and associated endocri
Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcoho
The three-year research project funded by MSB applies design science, in combination with traditional scientific investigation, to develop a method to guide the planning phase of capacity development projects for disaster risk reduction and climate change adaptation. The method facilitates local participation and ownership as it builds on the strengths of the Logical Framework Approach (LFA), whil
One of the most important factors governing durability of concrete structures is reinforcement corrosion, and to prevent degradation associated with it, it is desirable to use large concrete covers. However, if the concrete cover is increased, the majority of design methods will predict that the crack widths at the concrete surface increase significantly. This can be contradictory, since the same
Familial clustering of chronic obstructive pulmonary disease (COPD) is well established, but the familial risk of COPD has not been determined among adoptees. The aim was to determine whether the familial transmission of COPD is related to disease in biological and/or adoptive parents.
