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INTRODUCTION: In the wait for disease-modifying treatment for Parkinson’s disease (PD), efforts towards improved symptom control and reduced negative effects of PD can result in meaningful change patients. The general efficacy of levodopa-carbidopa intestinal gel (LCIG) in advanced PD has been established, but its effects on dyskinesia need more investigation. The PD Home Diary has been used in cl

C-telopeptide of type II collagen (CTX-II) has been shown to be a highly relevant biomarker of cartilage degradation in human rheumatic diseases, if measured in synovial fluid or urine. However, serum or plasma CTX-II have not been demonstrated to have any clinical utility to date. Here, we describe the GPDPLQ1237 ELISA which targets the EKGPDPLQ↓ neo-epitope, an elongated version of the CTX-II neC-telopeptide of type II collagen (CTX-II) has been shown to be a highly relevant biomarker of cartilage degradation in human rheumatic diseases, if measured in synovial fluid or urine. However, serum or plasma CTX-II have not been demonstrated to have any clinical utility to date. Here, we describe the GPDPLQ1237 ELISA which targets the EKGPDPLQ↓ neo-epitope, an elongated version of the CTX-II ne

While popular narratives about success in South Africa focus on individual effort, accidents of birth continue to determine life prospects. Inequalities in early childhood development, health, and education narrow the range of possibilities that young people have available to them, and this impacts on their risk appetite, including, through the workings of the maturing brain, a propensity to viole

Information and Communication Technologies (ICT) have relevant positive and negative impacts on environmental sustainability on various levels: First-order effects such as increasing electronic waste streams; second-order effects such as improved energy-efficiency of production; third-order effects such as a product-to-service shift in consumption or rebound effects in transport. In the simulation

The concept of smart specialization has attracted great interest and has been adopted widely in European regional and innovation policy. Foresight is an important part of creating smart specialization strategies. However, both the smart specialization concept and foresight have been criticized for lacking an empirical and theoretical foundation that can help guide their application in practice. Th

The concept of smart specialization has attracted great interest and has been adopted widely in European regional and innovation policy. Foresight is an important part of creating smart specialization strategies. However, both the smart specialization concept and foresight have been criticized for lacking an empirical and theoretical foundation that can help guide their application in practice. Th

Complexes trans-[PtRCl(SR‘2)2], where R = Ph, mesityl, and p-anisyl and R‘ = Me or Et, have been synthesized and their crystal and molecular structures determined. Crystals of trans-[PtPhCl(SEt2)2] (2) are triclinic (P1̄) with a = 10.112(6) Å, b = 13.158(2) Å, c = 14.714(5) Å, α = 102.48(2)°, β = 94.394(4)°, γ = 90.22(3)°, and Z = 4. Crystals of trans-[Pt(mesityl)Cl(SMe2)2] (4) are monoclinic (P21Complexes trans-[PtRCl(SR‘2)2], where R = Ph, mesityl, and p-anisyl and R‘ = Me or Et, have been synthesized and their crystal and molecular structures determined. Crystals of trans-[PtPhCl(SEt2)2] (2) are triclinic (P1̄) with a = 10.112(6) Å, b = 13.158(2) Å, c = 14.714(5) Å, α = 102.48(2)°, β = 94.394(4)°, γ = 90.22(3)°, and Z = 4. Crystals of trans-[Pt(mesityl)Cl(SMe2)2] (4) are monoclinic (P21

This article deals with a comparison between Matilde Serao’s short story “Checchina’s Virtue” ( 1884 ) and the homonymous unpublished theatrical script written by Massimo Franciosa ( 1995 ), of which a summary is provided. The comparison between the source text and the adaptation draws on the debate about the narrativity of drama in which many scholars have engaged in the last decades: Richardson

Purpose: The purpose of this article is to offer new insights into crisis communication in service ecosystems. The authors present a framework to conceptually categorize service crises and then analyze key aspects of crisis communication among different stakeholders in a service ecosystem. Design/methodology/approach: Building on crisis communication and service ecosystems research, we propose a f

This article is the outcome of two research trips to the Jain caves at Ellora, the purpose of which was to photograph the best preserved murals found there, works of art that were largely undocumented in any available literature. The article documents and portrays the best preserved paintings in detail found on the walls and ceiling of one of the smaller caves belonging to the largest Jain cave co

Models of service encounters are often fraught by reductionism, describing business relationships as mathematical combinations of dyadic constellations. Metaphors of ideal social relationships (marriages or friendships) are highlighted to stress normative aspects of equal, balanced and long-term business partnerships. However, these approaches are limited in their analytical sensitivity, as they c

Episodic memories typically comprise multiple elements. A defining characteristic of episodic retrieval is holistic recollection, i.e., comprehensive recall of the elements a memorized event encompasses. A recent study implicated activity in the human hippocampus with holistic recollection of multi-element events based on cues (Horner et al., 2015). Here, we obtained ultra-high resolution function

IntroductionInjury prevention training is effective in reducing injuries in youth team sports, but public health impact is limited because such training is not widely, properly, or sustainably implemented. Insufficient involvement of end-users has been identified as a main barrier to implementation. Based on results from previous studies within the I-PROTECT project, the aim was to develop a full

Mountains provide a variety of ecosystem services, such as drinking water, which sustains not only mountain communities but also people living further downstream. While climate change threatens most ecosystems, its negative impacts are up to three times greater in high altitudes. As well as changing the water cycle this further accelerates climate change. Although they contribute comparably little

In today's society, much energy is used and all energy use (e.g. heat, electricity) affects the environment. Greenhouse gas emissions from energy affect the climate of the earth and increase the natural greenhouse effect. Environmental impact because of energy use causes both local and global problems. Efficient energy use in buildings is a prerequisite for dealing with climate issues and in t

Abstract Purpose: The purpose of this thesis is to investigate how different types of fans experience personalization in sports marketing and to analyze how each Fan type can be motivated by understanding how their fan experience could be optimized further. Methodology: This study was a qualitative study. The study was carried out using an abductive approach where literature was combined with empi

Thesis purpose The purpose of our thesis is to explore how and why consumers with low prior knowledge educate themselves about sports supplements and what effect gender has. Methodology Our research derives from a pragmatic orientation. We conducted a multi-method qualitative study, combining observations and interviews in order to explore and understand the online customer journeys of consumers