Filtyp
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, affecting millions worldwide. The clinical presentation of AD is heterogenous and often complicated by the presence of multiple co-pathologies, which can overlap with features of other neurodegenerative disorders, underscoring the need for tools to aid accurate and timely diagnosis. Biomarkers for AD span multiple modalities a
Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children
Popular Abstract in Swedish Avhandlingen utgår från förhållandet att symtom på psykisk ohälsa har tenderat att öka över tid i exempelvis de undersökningar som görs regelbundet av hälsorisker och ohälsa i form av olika så kallade folkhälsoenkäter och liknande undersökningar av hälsoläget i den svenska befolkningen. Det finns en diskussion bland forskare kring vad denna tendens står för, exempelvis Mental disorders, especially depression, have been increasingly described as a growing burden to global public health. Critics argue, however, that the use of mental health surveys, underlying these descriptions, tends to overestimate the prevalence of mental disorders by not distinguishing everyday experiences of distress from pathological conditions. This medicalization of public health is belie
There is substantial evidence that preschooler’s performance in early math is highly correlated to math performance throughout school as well as academic skills in general. One way to help children attain early math skills is by using targeted educational software and the paper discusses potential gains of using such software to support early math development. Furthermore it is argued that the con
Tree phenology has been recognized as an important indicator of climate change, and a wide range of budburst models have been developed. The models differ in temperature sensitivity, and the choice of model can therefore influence the result of climate impact assessments. In this study we compared the ability of 15 models to simulate budburst of the main forest tree species in Sweden. Records on t
There is currently a strongly growing interest in obtaining optimal control solutions for vehicle manoeuvres, both in order to understand optimal vehicle behaviour and, perhaps more importantly, to devise improved safety systems, either by direct deployment of the solutions or by including mimicked driving techniques of professional drivers. However, it is non-trivial to find the right combination
Flow injection analysis provides a convenient platform for the use of biosensors in the monitoring of bio-processes. A major requirement in bioprocess monitoring is real time information about various process parameters like concentration of products and substrates, flow rates, and injection volumes. Depending on the application, the monitoring requirements vary and this results in a need for diff
Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson's disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patients begins several years before the manifestation of the clinical symptoms, pointing to serious flaw/limitations in this approach.
Popular Abstract in Swedish Immunsystemet är ett invecklat och komplext system som finns överallt i kroppen och som inte är begränsat till ett enda organ. Vi utsätts hela tiden för ”angrepp” från mikro-organismer (t.ex. bakterier eller virus) men också för främmande ämnen som kan vara skadliga eller giftiga. Immunsystemets huvudfunktion är att hjälpa kroppen att känna igen dessa ”angripare” och atThe overall aim of this PhD project was to gain insight into the incidence of primary immunodeficiency (PID) in southern Sweden and to optimize diagnostic and treatment measures for these patients. We estimated the occurrence rate of PID in the pediatric population of southern Sweden during a period of 4 years and described the demographic, clinical and immunological characteristics of the identif
Popular Abstract in Swedish För tidigt födda barn genomgår intensivvård under en period när de är väldigt sårbara pga instabil cirkulation och ett omoget centralt nervsystem under snabb utveckling. Tillräcklig behandling av smärta är av största betydelse eftersom stark smärtupplevelse kan medföra skadliga omedelbara kroppsreaktioner, men också neurologiska och neuropsykologiska seneffekter. Det fiPreterm infants undergo intensive care during a vulnerable period with hemodynamic instability and a rapidly developing and immature CNS. Adequate pain management is essential, since pain experience might lead to acute physiological reactions as well as neurological and neuropsychological sequels. There is no “golden standard” for objective pain assessment, and no evidence-based recommendations fo
The PreSPEC setup for high-resolution 'gamma-ray spectroscopy using radioactive ion beams was employed for experimental campaigns in 2012 and 2014. The setup consisted of the state of the art Advanced GAmma Tracking Array (AGATA) and the High Energy gamma cleteCTOR (HECTOR+) positioned around a secondary target at the final focal plane of the GSI FRagment Separator (FRS) to perform in-beam gamma-r
Spectral estimation is an important classical problem that has received considerable attention in the signal processing literature. In this contribution, we propose a novel method for estimating the parameters of sums of complex exponentials embedded in additive noise from regularly or irregularly spaced samples. The method relies on Kronecker's theorem for Hankel operators, which enables us to fo
We report on the production and characterization of polymer-based ultra-thin (sub 10 nm) foils suited for experiments on laser-ion acceleration in the regime of radiation pressure acceleration. Beside the remarkable mechanical stability compared with commonly used diamond-like-carbon foils, a very homogeneous layer thickness and a small surface roughness have been achieved. We describe the technic
1. Permutation tests are important in ecology and evolution as they enable robust analysis of small sample sizes and control for various forms of dependencies among observations. A common source of dependence is spatial autocorrelation. Accounting for spatial autocorrelation is often crucial, because many ecological and evolutionary processes are spatially restricted, such as gene flow, dispersal,
To support learning, a sense of trust between student and teacher is required. This assumption is discussed in relation to three human conditions: the biological, the moral and the political. In the oral space of the classroom, teachers and students are dependent on these preconditions when asking: What is a we? What are we doing? What are we making? How emulation and the presence of trust play in
The following text addresses the threats aecting the honey-bee, and which are manifesting through the unusual death rates of bee colonies. Focus is placed in reviewing the scientic knowledge that concerns the honey-bee by discussing its cognitive and ethical categories and its in uence in nature conservation, mainly centred in the EU. Results indicate that scientic knowledge plays a fundamental ro
During the last several decades, improvements in diagnostic skills and in the treatment of children with cancer have substantially increased the number of long term survivors of childhood cancer. Treatment of children with cytostatic drugs is known to create a range of late adverse effects. Among these are damage to certain structures of the inner ear and hearing impairment. In children, a hearing
Five recent techniques from hybrid and optimal control are evaluated on two power electronics benchmark problems. The benchmarks involve a number of practically interesting operating scenarios for fixed-frequency synchronous dc-dc converters. The specifications are defined such that good performance can only be obtained if the switched and nonlinear nature of the problem is accounted for during th
