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Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,

Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under

In Sweden there was a government decision 2012 to implement a new level of care within the national psychiatric health care. The purpose with this study was to investigate the implementation ie a new means of organization in the psychiatric healthcare for children and adolescents in the city of Växjö. In this study we focus on the implementation nationwide in Sweden and specifically in our county.

Proteins are tiny chemical machines that play many critical roles in our body. Some proteins send important messages, some carry crucial supplies, some fight with invaders and protect body from diseases, some clear trash etc. Proteins are strings of hundreds and thousands of small units called amino acids. If the string is built from less than hundred amino acids, it is called a peptide. DNA, a loThe pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. Early on-set Alzheimer’s is caused by a variety of single amino acid substitu

This thesis concerns the legal consequences and the economic effects of the use of a damages clause (avtalsvite). Starting from a rather routinely picture in the legal literature, the thesis seeks to establish a more sophisticated application of the clause, in order to maximize the parties total utility.Thanks to their long-standing use, there is a generally accepted picture of what damages clauseThis thesis concerns the legal consequences and the economic effects of the use of a damages clause (avtalsvite). Starting from a rather routinely picture in the legal literature, the thesis seeks to establish a more sophisticated application of the clause, in order to maximize the parties total utility.Thanks to their long-standing use, there is a generally accepted picture of what damages clause

Primary immune thrombocytopenia is an autoimmune disease associated with a reduced peripheral blood platelet count. The phenotype is variable with some patients suffering no bleeding whilst others have severe bleeding which may be fatal. Variability in clinical behaviour and treatment responses reflects its complex underlying pathophysiology. Historically the management has relied heavily on immun

Parenting support constitutes a long-established part of both the Swedish and the German portfolio of public social services. It originated in the 1920s in Germany, the 1930s in Sweden. Support measures and underlying philosophies have steadily changed in both countries, thereafter. The 1990s saw a new ‘turn to parenting’ and also new measures in Sweden and Germany. In this article, we ask how par„Parenting“ und „Parenting Support“ in Deutschland und Schweden. Konvergenz und fortdauernde Unterschiede.

High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer, often discovered in advanced stages and linked to poor survival. Due to high mortality rates, there is a need for novel treatment strategies. A promising new strategy is induction of ferroptosis, which has recently been shown to synergistically induce cell death in HGSOCs in combination with MTDH-SND1 protein

Antikroppar har ett brett användningsområde med stor potential men det är svårt att skapa stabila lösningar. Den strukturella stabiliteten är en viktig faktor när man väljer läkemedelskandidater, och i de tidiga utvecklingsstadierna görs prediktiva undersökningar för att ta reda på varje kandidats stabilitet och utvecklings-potential. Därmed är det av största intresse att utvärdera hur antikropparA great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. The stability of the candidates can be estimated using different orthogonal techniques and the aim of this investigation was thus to use orthogonal techniques for the investigation of conformationa

2024 VT_LP2 FMSN55 CEQ Course evaluation ver 9.0 (2021-01-23) LTH Course evaluation report - CEQ, FMSN55 Basic facts Course name Statistical Modelling of Extreme Values Course code FMSN55 ECTS credits 7.5 hp Year 202324 Study period the course was finishedVT_LP2 Programme all Registrated students 68 Number answers and response rate 13 / 19 % Number answers from males 7 Number answers from females

https://www.maths.lu.se/fileadmin/maths/utbildning_education/Kursutv_VT24/FMSN55_2024_VT_LP2_arbetsrapport_en.pdf - 2026-05-07

CAMBODIA NATIONAL LAW AND POLICY REPORT CONSULTATION DRAFT 2020 Displacement in the Context of Disasters and Climate Change Funded by This report was prepared by Victor Bernard (RWI) and Matthew Scott (RWI) 2020 TABLE OF CONTENTS 1 INTRODUCTION 1 1.1. A human rights-based approach 1 2 Displacement in Numbers 3 2.1. Number of disasters and people affected in the last ten years (2009–2018) 3 3 Recom

https://rwi.lu.se/wp-content/uploads/2024/03/Consultation-Draft_Cambodia.pdf - 2026-05-08

Children in an asylum process are especially exposed in society. Therefore, a high standard is expected of the law enforcer’s investigation and assessment of the best interest of the child, within the rules for residence permit in the Aliens Act (2005:716). The regulation of the best interest of the child in the Aliens Act (2005:716) protect the child’s right to health and development which to a

Samband mellan selenbrist och försämrad prognos vid hjärtsvikt – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Samband mellan selenbrist och försämrad prognos vid hjärtsvikt 2019-08-21 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Runt 250 000 personer i S

https://www.vetenskaphalsa.se/samband-mellan-selenbrist-och-forsamrad-prognos-vid-hjartsvikt/ - 2026-05-08

Professor Kontaktinformation E-post: herve [dot] corvellec [at] ses [dot] lu [dot] se Telefon: +46 73 031 99 04 Mobil: +46 73 031 99 04Organisation Institutionen för tjänstevetenskap Rumsnummer: E321 WebbplatsHervé Corvellecs profil i Lunds universitets forskningsportalI was born in France, but I have been living in Sweden since 1985. I am a professor of Business Administration at the Department o

https://www.ses.lu.se/herve-corvellec-0 - 2026-05-07

The presence of endocrine disrupting compounds, so-called EDC’s, in aquatic environments has become an emerging issue for environmental health. Since the 1990’s these compounds have been displaying estrogenic effects on aquatic organisms downstream from sewage treatment plants (STPs). The cause of the problem is mainly the inability of conventional STP’s to remove these unwanted substances from ou

On July 2018, for the first time in modern Mexican history, a leftist candidate won the presidential elections in Mexico. With large promises on the eradication of corruption and ending social injustice, Andrés Manuel López Obrador and his party secured both the presidency and both chambers of the Mexican Congress. This paper inquires into to what extent a president belonging to the political left