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Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under

Abstract Background: Osteoarthritis (OA) is the most common joint disorder globally and a major cause of disabiltiy with the knee joint responsible for 80% of the disease burden. Progressive degenerative changes in cartilage tissue result in deterioration and loss of articular cartilage. Cartilage has poor capacity of healing and the detection of degeneration usually occurs at a stage of progressiAbstract Background: Osteoarthritis (OA) is the most common joint disorder globally and a major cause of disabiltiy with the knee joint responsible for 80% of the disease burden. Progressive degenerative changes in cartilage tissue result in deterioration and loss of articular cartilage. Cartilage has poor capacity of healing and the detection of degeneration usually occurs at a stage of progressi

This thesis concerns the legal consequences and the economic effects of the use of a damages clause (avtalsvite). Starting from a rather routinely picture in the legal literature, the thesis seeks to establish a more sophisticated application of the clause, in order to maximize the parties total utility.Thanks to their long-standing use, there is a generally accepted picture of what damages clauseThis thesis concerns the legal consequences and the economic effects of the use of a damages clause (avtalsvite). Starting from a rather routinely picture in the legal literature, the thesis seeks to establish a more sophisticated application of the clause, in order to maximize the parties total utility.Thanks to their long-standing use, there is a generally accepted picture of what damages clause

The presence of endocrine disrupting compounds, so-called EDC’s, in aquatic environments has become an emerging issue for environmental health. Since the 1990’s these compounds have been displaying estrogenic effects on aquatic organisms downstream from sewage treatment plants (STPs). The cause of the problem is mainly the inability of conventional STP’s to remove these unwanted substances from ou

https://rwi.lu.se/blog/page/26/ - 2026-05-04

The aim of this article is to present the archival practice behind two extensive research projects that we have worked on during the last decade: the Stockholm Film Workshop and minor immigrant filmmaking in Sweden. Archive has become a general catchword in today’s academia that encompasses several practices of collecting, storing, distributing and displaying. We will stress in particular – partlyThe aim of this article is to present the archival practice behind two extensive research projects that we have worked on during the last decade: the Stockholm Film Workshop and minor immigrant filmmaking in Sweden. Archive has become a general catchword in today’s academia that encompasses several practices of collecting, storing, distributing and displaying. We will stress in particular – partly

The main purpose of this study is to examine whether a specific group of non ideal crime victims senses that the standard view of the ideal crime victim stands in the way of them getting the help from the judiciary that they are entitled to. If a discrepancy between theory and practice do exists, then why does it exist and what changes need to be done to eliminate it? These questions have been s

Children in an asylum process are especially exposed in society. Therefore, a high standard is expected of the law enforcer’s investigation and assessment of the best interest of the child, within the rules for residence permit in the Aliens Act (2005:716). The regulation of the best interest of the child in the Aliens Act (2005:716) protect the child’s right to health and development which to a

Capitulation is wisdom - not defeat! The aim of this study has been an attempt to clarify how parents of children with neuropsychiatric disabilities such as autism, Down syndrome and intellectual disability manage to cope in their everyday life despite the high levels of stress and long term strain it involves being a parent and a caretaker of such a child. We focused our study on the family as a

2022-08-15ContentsFactors which are likely to have an effect on the emergence of cancer and cardiovascular diseases, such as education, occupation, physical load, psychosocial working environment, social relations, physical activity, sleep, tobacco and alcohol consumption, health, diseases in the family, use of contraceptive pills etc.Lines: 28 577Variables: 291SourcesData have been derived from t

https://www.malmo-kohorter.lu.se/malmo-kost-cancer-mkc/datainsamling-mkc/mdc-questionnaire - 2026-05-05

BACKGROUND/AIM: Diagnostic efficacy, defined as the percentage of rectal suction biopsy (RSB) specimens sufficient enough to determine the absence of ganglia cells in Hirschsprung's disease (HD) diagnosis, has been reported to be low, requiring repeated biopsies. The aim was to explore whether RSB diagnostic efficacy was influenced by the child's weight and to ascertain whether RSB efficacy differ

Several monouranium and diuranium polyhydride molecules were investigated using quantum chemical methods. The infrared spectra of uranium and hydrogen reaction products in condensed neon and pure hydrogen were measured and compared with previous argon matrix frequencies. The calculated molecular structures and vibrational frequencies were used to identify the species present in the matrix. Major n

The implementation of new data regulation has put pressure on organizations to govern their data. However, research on data governance typically focuses on the optimal design of rules and decisionmaking about data. In this paper, we argue that the significant work that goes into responding, when data use is challenged on the basis of regulation, is a legitimate subset of data governance practice.

This paper reconsiders how central banks get involved in the process of determining nominal variables such as market interest rates and inflation rates. It is argued that the traditional story deriving central bank power from its monopoly of issuing base money is flawed. That story - in its various guises - is based on the quantity equation. This equation, however, is only applicable in the hypoth

Proteins are tiny chemical machines that play many critical roles in our body. Some proteins send important messages, some carry crucial supplies, some fight with invaders and protect body from diseases, some clear trash etc. Proteins are strings of hundreds and thousands of small units called amino acids. If the string is built from less than hundred amino acids, it is called a peptide. DNA, a loThe pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. Early on-set Alzheimer’s is caused by a variety of single amino acid substitu

The term mission in its modern meaning was coined during the expansion of western Christianity which was in many ways entangled with colonialism. The western missionary movement’s modus operandi was adopted by missions from other backgrounds as well, when economic growth and growth of revivalist Christianity have coincided. When the outcome is new churches in economically underprivileged areas, th

Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody responses targeting the M protein have been shown to favor the conserved C region. Such antibodies (Abs) c