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Purpose EURAMOS-1, an international randomized controlled trial, investigated maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose osteosarcoma showed good histologic response (good response) to induction chemotherapy. Patients and Methods At diagnosis, patients age ≤ 40 years with resectable high-grade osteosarcoma were registered. Eligibility after surgery for good
AimTo reconstruct spatial and temporal patterns of European fire activity during the Holocene and to explore their potential drivers, by relating biomass burning to simulated biotic and abiotic parameters. LocationEurope. MethodsHolocene fire activity was investigated based on 156 sedimentary charcoal records from lakes and peat bogs across Europe. Charcoal data covering the last 9000 years were s
QuestionHow do pollen-based functional and phylogenetic diversity help to explain post-glacial vegetation change in relation to climate and human influence? LocationEstonia and Latvia, NE Europe. MethodsWe used a data set of 1062 pollen samples from 20 sites covering the last 14500yrs to estimate plant richness, evenness, functional and phylogenetic diversity (community-weighted mean and mean pair
In patchily distributed species dispersal connects local populations into metapopulations. Reliable quantifications of dispersal are therefore crucial to understanding the population dynamics and genetic structure of such metapopulation systems. The great reed warbler (Acrocephalus arundinaceus) inhabits eutrophic lakes and has a patchy breeding distribution. In this study we investigated the disp
In nonequimolar solutions of a cationic and an anionic surfactant, vesicles bearing a net charge can be spontaneously formed and apparently exist as thermodynamically stable aggregates. These vesicles can associate strongly with polymers in solution by means of hydrophobic and/or electrostatic interactions. In the current work, we have investigated the rheological and microstructural properties of
Understanding and managing the responses of natural systems to climate change requires knowing whether recent changes in ecosystem structure and function are within the bounds of natural variation or whether the systems are entering new states that are unprecedented. Several recent studies of the fossil diatom record of the last ~ 150 years in Andean lakes have shown changes in diatom species comp
Two signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal to the T cell, while the second signal is provided by interaction with costimulatory ligands on APC. CD2, LFA-1, and CD28 are the major costimulatory and adhesive molecules on T cells and bind to the LFA-3, ICAM
OBJECTIVES: One of the theories connecting enterovirus (EV) infection of human islets with type 1 diabetes (T1D) is the development of a fertile field in the islets. This implies induction of appropriate proteins for the viral replication such as the coxsackie-adenovirus receptor (CAR). The aim of this study was to investigate to what extent CAR is expressed in human islets of Langerhans, and what
Sda is a high-frequency carbohydrate histo-blood group antigen, GalNAcβ1-4(NeuAcα2-3)Galβ, implicated in pathogen invasion, cancer, xenotransplantation and transfusion medicine. Complete lack of this glycan epitope results in the Sd(a−) phenotype observed in 4% of individuals who may produce anti-Sda. A candidate gene (B4GALNT2), encoding a Sda-synthesizing β-1,4-N-acetylgalactosaminyltransferase
Avhandlingens titel "Kustnära yrkesfiske i förändring. Från mångsysslare till entreprenör" hänvisar till de förändringar som fiskenäringen har genomgått under flera decennier. Fiskenäringen har rationaliserats samtidigt som besöksnäringen vid kusten expanderat. Antalet yrkesfiskare i kustnära yrkesfiske har därför minskat och näringen måste förhålla sig till nya informella krav och förväntningar pIn this dissertation inshore commercial fisheries are being studied from a cultural analytical perspective with a focus on service production and hospitality. The dissertation title, ”Inshore commercial fisheries in change. From pluri-activity to entrepreneurship”, refers to the multiple kinds of change that the fishing industry has undergone for a long period in time. They include rationalization
OBJECTIVES: Primary graft dysfunction is a severe form of acute lung injury and a major cause of early morbidity and mortality encountered after lung transplant.We used a customized PExA 2.0 instrument (PExA, Gothenburg, Sweden) to measure particle flow in exhaled air during mechanical ventilation in the intensive care unit. Our objective was to discover whether patients who developed primary graf
To better predict the timely variation of algal blooms and other vital factors for safer drinking water production, a new AI scanning–focusing process was investigated for improving the simulation and prediction of algae counts. With a feedforward neural network (FNN) as a base, nerve cell numbers in the hidden layer and the permutation and combination of factors, etc., were fully scanned to selec
The small body of research on writing and writing processes in the group of deaf and hard of hearing (DHH) children has shown that this group struggles more with writing than their hearing peers. This article aims to explore in what ways the DHH group differs from their peers regarding the written product and the writing processes. Participants are all in the age span 10–12 years old and include:
Objective: to compare self-rated health and perceived difficulties during pregnancy as well as antenatal attendance, birth experience and parental stress in fathers with and without childbirth related fear. Design: a longitudinal regional survey. Data were collected by three questionnaires. Setting: three hospitals in the middle-north part of Sweden. Participants: 1047 expectant fathers recruited
Sediment records recovered from the Baltic Sea during Integrated Ocean Drilling Program Expedition 347 provide a unique opportunity to study paleoenvironmental and climate change in central and northern Europe. Such studies contribute to a better understanding of how environmental parameters change in continental shelf seas and enclosed basins. Here we present a multi-proxy-based reconstruction of
Two independent studies have revealed a potential limitation of post-mode switch overdrive pacing (PMOP), which is its delayed start. We conducted a prospective, randomized, single blind, crossover design study (the post-long pause overdrive pacing study) to test the efficacy of an improved version of PMOP (PMOPenhanced). A total of 45 patients were enrolled, of whom 41 were analysed. The median n
Previous studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Invest
