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Streptococci and Platelets - A Study of Host-Pathogen Interaction Dynamics

Invasive infections remains one of the leading causes of death due to infections over the world, and efficient treatment remains elusive. One of the major causes of sepsis and other invasive infections is pathogenic streptococci that cause a wide range of clinical manifestations in humans. Group A and group G streptococci have both been shown to cause both infections of milder ranges as well as se

Water erosion modeling using fractal rainfall disaggregation- a study in semiarid Tunisia

In the Tunisian semiarid area, water erosion processes have led to negative economic and environmental consequences in a context of limited water resources. To characterize and predict these degradation phenomena, a comprehensive high-resolution data base on erosive rainfall, together with siltation records for 28 small reservoirs were analyzed. The studied small reservoir network displays a gener

THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate

Popular Abstract in Swedish Stamceller är unika celler som har möjlighet att både förnya sig själva och ge upphov till en mängd mogna celler. Den ultimata stamcellen är det befruktade ägget, som är den cell som efter omfattande celldelning kommer att ge upphov till alla vävnader och celler i den färdigutvecklade kroppen. Dessa celler kallas därför pluripotenta. Även i den färdigutvecklade kroppen Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. Because of these features, HSCs are also the basis for bone marrow transplantation regimens for tr

Lake ecosystem responses to catchment disturbance and airborne pollution: an 800-year perspective in southern Sweden

Sediment sequences spanning the last 800 years from two small lakes in the south Swedish uplands were explored for assessment of effects of changing human population, local land-use practices and airborne pollution on lake-ecosystem functioning and resilience. Variations in nutrient cycling and deposition of lithogenic elements were studied, using a multi-proxy stratigraphic approach. Carbon and n

Secundum atrial septal defect in the adult. Clinical, haemodynamic and electrophysiological aspects.

Atrial septal defect (ASD) is the most common congenital heart malformation diagnosed in adult life. In this thesis important clinical, haemodynamic and electrophysiological aspects of ASD in the adult are explored. The diagnostic accuracy of magnetic resonance velocity mapping (MRvm)in calculating the pulmonary/systemic flow ratio (QP/QS)was assessed (I). The mean and maximal error by MRvm was 1

Sick leave and disability pension among Swedish testicular cancer survivors according to clinical stage and treatment

Purpose. To investigate if testicular cancer survivors (TCSs) have a higher incidence of work loss compared with the population, accounting for stage, treatment and relapse.Material and methods. A cohort of 2146 Swedish TCSs diagnosed 1995-2007 (seminoma n = 926, non-seminoma n = 1220) was identified in the SWENOTECA (Swedish-Norwegian Testicular Cancer Group) register, and matched 1:4 to populati

Portfolio Strategies based on Fundamental Weighting: An Empirical Study of the Swedish Stock Market

Purpose: The aim of this study is to investigate if portfolios whose composition is based on fundamental values (FVs) outperform a market value (MV)-weighted benchmark portfolio in terms of mean-variance efficiency on the Swedish stock market. We also seek to answer if an investment strategy, which focuses on the difference in composition between these two weighting methods, can further enhance th

Utveckling av VDC inom mark och anläggning

This report presents how far NCC current VDC tools and methods in building construction can be implemented in road and infrastructure projects also what new tools, methods that can be created helped by pre-selected software’s. VDC is well developed within the construction of building and research and resources in the field have been spent under a longer period of time unlike in road and infrastruc

Europakonventionens tillämpning på förhållandet mellan enskilda i Arbetsdomstolens praxis

I syfte att skydda medborgare från övergrepp begångna av staten har ett antal europeiska länder undertecknat Europakonventionen. De fri- och rättigheter som Europakonventionen består av är allmänt formulerade och för deras efterlevnad ansvar både de länder som undertecknat konventionen och den Europeiska domstolen. Europakonventionens rättsliga status i Sverige var till en början osäker. SvenskaIn order to protect citizens from abuse commited by the state several European countries signed the European Convention of Human Rights (ECHR) in the aftermath of World War II. The rights and freedoms which the Convention consisted of was generally formulated. Both signatory countries and the European Court of Human Rights was responsible for its enforcement. Although Sweden was one of the origin

Elevated CD14++CD16- Monocytes Predict Cardiovascular Events.

BACKGROUND: -Although monocytes in peripheral blood are no longer considered to be a homogeneous population, associations between distinct monocyte subsets and cardiovascular disease have not been highlighted in large epidemiological studies. METHODS AND RESULTS: -The study included 700 randomly selected subjects from the cardiovascular arm of the Malmö Diet and Cancer study. Among these, 123 subj

Prevalence and clinical spectrum of chronic viral hepatitis in a middle-aged Swedish general urban population

BACKGROUND: Although abundant data are available regarding the prevalence of chronic hepatitis B or C virus (HBV, HCV) among both blood donors and patients with liver diseases, corresponding data for the general population are scarce. Accordingly, this study was designed to investigate the prevalence and clinical spectrum of HBV and HCV in a general Swedish middle-aged urban population. METHODS: D

Retroviral gene transfer to repopulating hematopoietic cells

Popular Abstract in Swedish Blodbildande stamceller förekommer i mänsklig benmärg i en frekvens på ca 1/100 000 celler. Med hjälp av cellytemarkörer, t.ex. CD34, kan man rena fram cellpopulationer som är anrikade på stamceller, men det saknas exakt kunskap om hur enskilda stamceller ser ut. De blodbildande stamcellerna har förmåga att vid celldelning antingen förnya sig själva eller att mogna ut. Hematopoietic stem cells (HSCs) have the capacity to maintain hematopoiesis throughout life. HSCs are ideal targets for permanent gene transfer, as the transgene will be expressed in all the progeny of the gene-modified stem cells. The aim of this thesis was to optimize conditions for retroviral gene transfer to human candidate HSCs and to study mechanisms interfering with efficient gene transfer.

On the Construction and Analysis of Iteratively Decodable Codes

Iterative decoding methods allow efficient decoding of long codes that are composed of smaller component codes. As a result reliable communication can be achieved with low decoding complexity even for rates close to Shannon capacity. This makes iteratively decodable codes a very attractive object of study in modern coding theory. This thesis focuses on different kinds of cycles which appear in th

Genetic Analysis of Cytosolic PGI in Festuca ovina

Popular Abstract in Swedish Mitt försöksmaterial utgjordes av Festuca ovina, fårsvingel, som är ett mycket vanligt gräs och tillhör familjen Poaceae. Fårsvingel är en perenn korsbefruktare och spridd över den tempererade zonen i Euroasien och Nordamerika. Släktet Festuca är uppdelat i smalbladiga svinglar, dit fårsvingel hör, och bredbladiga svinglar. Släktet Lolium, dit rajgrFestuca ovina, sheep's fescue is a widely distributed perennial outbreeder that belongs to the grass family Poaceae and is very common in the northern temperate zone. The genus Festuca s.l. is partitioned into fine-leaved fescues to which F. ovina belongs, and broad-leaved fescues to which the genus Lolium is a close relative. Wide crosses within the Festuca-Lolium

Muscular exercise can cause highly pathological liver function tests in healthy men.

What is already known about this subject • The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of clinical drug development and the leading cause of postmarketing warnings and withdrawals. • Physical exercise can result in transient elevations of liver function tests. • There is no consensus in the literature on which forms of exercise may cause changes in liver