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Background Local pain on injection of propofol remains a considerable problem in clinical anaesthesiology. As slow infusion of a low dose of propofol induces little or no pain at the site of injection, and as propofol-induced pain fades during prolonged exposure, this randomized, double-blind, clinical cross-over study was designed to test whether pain on injection of propofol is attenuated by ini
Recent progress on the nature of short-duration gamma-ray bursts has shown that a fraction of them originate in the local Universe. These systems may well be the result of giant flares from soft gamma-repeaters (highly magnetized neutron stars commonly known as magnetars). However, if these neutron stars are formed via the core collapse of massive stars then it would be expected that the bursts sh
Research on event-related potential (ERP) correlates of auditory deviance-detection in newborns provided inconsistent results; temporal and topographic ERP characteristics differed widely across studies and individual infants. Robust and reliable ERP responses were, however, obtained to sounds (termed 'novel' sounds), which cover a wide range of frequencies and widely differ from the context provi
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder directed against the β cells of the pancreatic islets. The genetic risk of the disease is linked to HLA-DQ risk alleles and unknown environmental triggers. In most countries, only 10-15% of children or young adults newly diagnosed with T1DM have a first-degree relative with the disease. Autoantibodies against insulin, GAD65, IA-2 or the ZnT
Context Agricultural transformation and increased land use intensity often lead to simplified landscapes and biodiversity loss. For animals, one possible mechanism underpinning biodiversity loss in agricultural landscapes is the disruption of movements. The disruption of movements may explain, for example, why butterfly communities in agricultural landscapes are often dominated by generalist speci
Background: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33 degrees C or 36 degrees C temperature control for 24 hours after cardiac arrest and the effects on survival and neurological outcome assessed. This protocol describes a sub-study of the TTM-trial i
The glial cell line-derived neurotrophic factor (GDNF) has an important role in neuronal survival through binding to the GFRα1 (GDNF family receptor alpha-1) receptor and activation of the receptor tyrosine kinase Ret. Transient brain ischemia alters the expression of the GDNF signaling machinery but whether the GDNF receptor proteins are also affected, and the functional consequences, have not be
Physical properties of aqueous solutions of hydrophobically modified crosslinked polyacrylic acids change quite extensively as the polymer is charged up. A study is carried out concerning the similarities between two polymer ionization processes, that is, by pH increment and anionic surfactant addition. The two processes charge the polymer by distinctly different mechanisms. At sufficiently high p
Iron-centered N-heterocyclic carbene compounds have attracted much attention in recent years due to their long-lived excited states with charge transfer (CT) character. Understanding the orbital interactions between the metal and ligand orbitals is of great importance for the rational tuning of the transition metal compound properties, e.g., for future photovoltaic and photocatalytic applications.
This thesis has investigated the potential of combining Raman spectroscopy with Sheimpflug Light Detection and Ranging (lidar) for simultaneous characterization and ranging of aerosolized soot. The first part of the project involved the implementation of conventional non-ranging Raman spectroscopy for both deposited and aerosolized soot. The second part constituted the design, modelling, and evalu
Boreal peatlands strongly affect the global climate system by providing an important store for carbon (C) cycle and a natural source of methane. Over the past century, however, vast areas of natural peatlands have been drained to gain productive land, turning them into large potential C sources. Currently, there is a scientific debate on how to best manage historically drained boreal peatlands to
Bridge monitoring is essential for ensuring their long-term safety, reducing disruptions, and supporting economic and social activities. Traditional monitoring techniques rely on periodic inspections and contact-based sensing systems, which, while effective, have limitations due especially to high installation and maintenance costs. Satellite-based Synthetic Aperture Radar Interferometry (InSAR) o
Dark matter (DM) is one of the major components in the Universe. However, at present its existence is still only inferred through indirect astronomical observations. DM particles can annihilate or decay, producing final-state Standard Model pairs that subsequently annihilate into high-energy γrays. The dwarf spheroidal galaxies (dSphs) in the Milky Way DM halo have long been considered optimal tar
Human-induced habitat loss, fragmentation and degradation are among the leading causes of species decline worldwide. This is particularly true in tropical forests, where unique, often highly specialized fauna is under threat. By altering resource availability, anthropogenic habitat change can impose resource constraints on animals and may influence their allocation of resources to competing life h
Systematic assessments of cognition, fatigue, and mental health in survivors ofchildhood cancer can serve two different purposes. One is to enable research about development over time and medical predictors of cognitive deficits. The other is to identify individual patients in need of rehabilitation or interventions. The overall aim of this doctoral thesis was to contribute to the ongoing developm
Sweden's strategy to manage the spread of Covid-19 has not included any form of lockdown, in contrast to the approaches adopted by most other countries. Instead, the strategy has been largely based on strong recommendations for society. Even though Sweden has not had any form of lockdown, the Covid-19 pandemic has during a relatively short period of time brought changes for society, significantly
Background: The purpose of this study is to investigate the impact of oxygen therapy on cardiovascular outcomes in relation to sex in patients with confirmed myocardial infarction (MI). Methods: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction trial randomized 6,629 patients to oxygen at 6 L/min for 6-12 hours or ambient air. In the present subgroup analysis includi
Over the last decades, the field of thermal neutron detection has overwhelmingly employed He-3-based technologies. The He-3 crisis together with the forthcoming establishment of the European Spallation Source have necessitated the development of new technologies for neutron detection. Today, several promising He-3-free candidates are under detailed study and need to be validated. This validation p
In this preview of the introduction of the special issue of the AILA Review (Volume 34, Number 1), we focus on developing shared languages in and across domains and professional settings. The relation and collaboration between researchers and practitioners has long been discussed within and across applied sciences and theoretical disciplines, mainly in the framework of transdisciplinarity (see AIL
