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Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy in cancer and normal cell lines. The aim of this study was thus to investigate a potential role of SIK2 in the regulat

Heritopia explores the multiple meanings of the past in the present, using the famous temples of Abu Simbel and other World Heritage sites as points of departure. It employs three perspectives in its attempt to understand and explain both past and present: the truth of knowledge, the beauties of narrative, and ethical demands. Crisis theories are rejected as nostalgic expressions of contemporary s

This article looks at the politics of shame in relation to the suppressed protests of December 2010 that challenged the re-election of Aliaksandr Lukashenka as president of Belarus (1994–present). My empirical data consist of independent media publications, blog posts, and interviews that speak of “shame” as an emotional response to the protest, its aftermath, and its general context. The article

OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE).METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each

Abstract Noroviruses are now the leading cause of gastroenteritis worldwide. Noroviruses are effectively transmitted due to a low infectious dose, viral shedding in high concentrations, environmental stability, and they induce only a limited immunity after infection. Especially, the norovirus variants of genotype II.4 (GII.4) have seemed greatly adapted for pandemic spread. The high infectivity of

Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was

This study examines the views of stakeholders involved in house renovations regarding the one-stop-shop business concept innovation, and assesses their level of preparedness to adopt such a concept in order to enter the promising market of detached house renovations. The investigation is based on 25 interviews with construction SMEs owners, real estate agents and loan consultants, and on a concept

Systematic evaluations are vital to support learning and enhance performance in a crisis response. There are quantitative methods available today for evaluating crisis response management (CRM), but there are limiting factors negatively affecting their potential; They often involve techniques difficult to implement in real events, lack reliability testing, provide outcomes questionable from a lear

Background: Quantitative cardiovascular magnetic resonance (CMR) first pass perfusion maps are conventionally acquired with 3 short-axis (SAX) views (basal, mid, and apical) in every heartbeat (3SAX/1RR). Thus, a significant part of the left ventricle (LV) myocardium, including the apex, is not covered. The aims of this study were 1) to investigate if perfusion maps acquired with 3 short-axis view

The Sámi people stand out as the only Indigenous minority in an egalitarian European context, namely the Nordic Countries. Therefore, inequalities that they may face are worth closer inspection. Drawing on the distinction between inequalities among individuals (vertical) and between groups (horizontal), we investigate how different types of inequalities affect the Sámi today. We formulate a series

This study investigates the influence of CEO characteristics on corporate cash holdings. Previous research has already led to an extensive body of firm specific determinants of such, which connects tradeoff, agency and other theories. The upper echelons theory has until present not experienced major attention with regard to this field. This work shows that idiosyncratic managerial values, cognitiv

Häktning är det mest ingripande av våra personella tvångsmedel. Oskyldig eller inte följer det av svensk lag att varje intagen ska behandlas med respekt för sitt människovärde. Vidare ska verkställigheten av häktningen utformas så att negativa följder motverkas, med sådana följder avses bland annat psykiska, sociala och ekonomiska konsekvenser som kan följa av ett frihetsberövande. Om det finns riPre trial detention is a coercion measure where a suspect is incarcerated between the time he or she is being arrested until the trial. A pre trial detainee is considered innocent until proven guilty and thus it is important that the detention is not used as a punishment or rehabilitation. Whether a detainee is innocent or not he or she should be treated with respect for his or her human dignity.

Friköps-, utköps- och budgivningsklausuler i aktieägaravtal är ett ämne som det idag finns undermålig kunskap och forskning om i det svenska näringslivet och associationsrätten. Friköps- och utköpsklausuler ger aktieägare möjligheter som ABL motstrider och som i bolagsordning begränsar. Denna uppsats undersöker aktieägaravtals förmåga att realisera överlåtelsebindningar som låter aktieägare begränBuy out clauses in shareholders’ agreement is a subject with defeciant knowledge and research in Swedish business and Swedish business law. Buy out clauses gives shareholders’ possibilities that neither Swedish company law or Swedish companies’ articles of associations allows. This thesis investigates the shareholders’ agreements possibilities to implement restrictions on the transferability on co

The purpose of our essay was to analyze stories about Housing first, an effort to fight homelessness in social services. We have taken part of previous research regarding Housing first both national and international and the staircase model which is the most common effort in Sweden towards the homeless. The analysis is based on both professionals and clients stories regarding the subject and we ha

Concepts are important to help us understand the world around us. The way we define concepts has an impact on how we perceive reality. I have studied the concept ”labour party”, and how that concept was “hijacked” from the Social Democratic Party to the Conservative Party. I have searched for articles in Swedish printed press and internet sources between 01 January 2004 and the election on 17 Sept

Creating music have always been a hard thing to do, as time have passed there have been much research done on the topic of creating high quality music. New approaches and theories are appearing on how to generate music, the latest one (as writing this paper) is based on deep neural networks. In this paper Nottinghams abc notation database will be the main training set used as training data for the

This project investigates ethnic and gendered oppression in relation to the construction of cultural identity in the Bangladeshi diaspora as it is depicted in Monica Ali’s novel 'Brick Lane'. I read Ali’s novel as a 'feminist Bildungsroman' with the key focus on how the female migrant protagonist Nazneen’s changing self-conception and construction of a new identity in London leads

This study aims to investigate whether investing in environmentally friendly companies has a positive effect on risk-adjusted returns. We construct two portfolios: one portfolio consists of the 100 highest ranked companies from Newsweek’s yearly green rankings from 2017, and one portfolio consists of 122 companies that 2018 are blacklisted for environmental reasons by four asset managers: Nordea,

This paper investigates empirical determinants of current account positions worldwide with a focus on the countries that started out as the European Monetary Union (including Greece that joined in 2001). Specifically, it addresses the question whether current accounts inside the Eurozone have reacted more sensitively to changes in macroeconomic fundamentals due to the facilitation of inter-country

The aim of this thesis is to highlight what makes a good bicycle infrastructure with the goal to increase bicycling in urban areas. The focus has been to evaluate the bicycle infrastructure in the city of Lund, by investigating the differences between the main bicycle routes and the regular bicycle network in the city. A literature review of both scientific literature and bicycle planning manuals