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Reproductive Factors, Sex Hormone Levels, and Differentiated Thyroid Cancer Risk : A Mendelian Randomization Study

Background: Differentiated thyroid carcinoma (DTC) is occurring three times more frequently in females than in males. However, the underlying biological mechanisms driving this discrepancy remain poorly understood. To investigate the causal role of sex hormones and reproductive factors in the risk of DTC, we implemented a two-sample Mendelian randomization (MR) analysis. Methods: We utilized genom

Environmental factors influence airborne microplastic deposition in the soil of urban allotment gardens

The widespread contamination of urban soils by airborne microplastics (MPs) is an emerging environmental issue, particularly in urban allotment gardens with home-grown food. This study investigates the vertical distribution of MP in three such gardens in Berlin, Germany, over 90 days. Soil samples were collected at three depths (0-1 cm, 1–15 cm, and 15–30 cm) and analyzed for MP composition and oc

Insights into the Interconnected Dynamics of Groundwater Drought and InSAR-Derived Subsidence in the Marand Plain, Northwestern Iran

Groundwater drought, a significant natural disaster in arid and semi-arid regions, contributes to numerous consecutive issues. Due to the inherent complexity of groundwater flow systems, accurately quantifying and describing this phenomenon remains a challenging task. As a result of excessive agricultural development, the Marand Plain in northwestern Iran is experiencing both groundwater drought a

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The recent increase in the breeding population and the phenology of roosting Great Cormorants (Phalacrocorax carbo) are well described, but little is known about their migration patterns away from coastal areas. The few published data are based on older investigations, when the Cormorant was a rare breeding bird in Europe and thus a very rare migratory bird in inland parts of Central Europe. As a

Overt and null subjects in the two varieties in Venetian-Italian school children

This study investigates subject use in [-topic shift] and [+topic shift] contexts in Standard Italian and Venetian - two close varieties which differ in their use of overt and null pronouns. In an acceptability judgment, we compare two groups of bilectals in their two varieties: children aged 7-12 years, divided in strong and weak dialect speakers, and an adult control group. All groups show diffe

Trust in the healthcare system and mortality : A population-based prospective cohort study in southern Sweden

Aims: To investigate associations between trust in the healthcare system and all-cause, cardiovascular, cancer and other causes mortality. Study design: Prospective cohort study. Methods: A public health questionnaire was conducted in 2008 in Scania, the southernmost part of Sweden, with a 54.1% participation rate with a postal questionnaire and three reminders. In this study 24,833 respondents we

Hand function 6 weeks following non-surgically treated proximal phalangeal fractures and factors associated to upper extremity disability

Purpose: To describe hand function, and investigate adherence to a rehabilitation protocol and factors associated with upper extremity disability in non-surgically treated proximal phalangeal fractures. Material and methods: In a prospective cohort study, 86 patients (58 women, mean age of 49 years) were assessed at cast removal and 6 weeks follow-up. Adherence was registered in a diary. Factors p

Extremal states and coupling properties in electroelasticity

Electroelastic materials possess properties most attractive for the design of smart devices and systems such as actuators and sensors. Typical polymers show changes in shape under the action of an electric field, and vice versa, together with fast actuation times, high strain levels and low elastic moduli. This paper deals with an Ogden model inspired framework for large deformation electroelastic

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Retrospective studies suggest increased postoperative morbidity among alcohol misusers. We have prospectively studied the risk associated with alcohol intake among patients undergoing surgery. We investigated 15 persons who required colorectal surgery and who were drinking at least five Danish drinks per day. These patients were matched for sex, nutrition, age, weight, cardio-pulmonary disease, di

Neurodevelopmental disorders and somatic diagnoses in a national cohort of children born before 24 weeks of gestation

AIM: This study investigated childhood diagnoses in children born extremely preterm before 24 weeks of gestation.METHODS: Diagnoses of neurodevelopmental disorders and selected somatic diagnoses were retrospectively retrieved from national Swedish registries for children born before 24 weeks from 2007 to 2018. Their individual medical files were also examined.RESULTS: We studied 383 children born

Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases : A randomized eortc intergroup phase ii study (EORTC 40004)

Background: This study investigates the possible benefits of radiofrequency ablation (RFA) in patients with non-resectable colorectal liver metastases. Methods: This phase II study, originally started as a phase III design, randomly assigned 119 patients with non-resectable colorectal liver metastases between systemic treatment (n = 59) or systemic treatment plus RFA (± resection) (n = 60). Primar

Keeping in time : The design of qualitative longitudinal research in SLA

Language development is a long-term process. Individual-level longitudinal case studies have been foundational to SLA. However, methodologies that can support person-focused and process-oriented research lack consolidation. Qualitative longitudinal (QL) research (Neale, 2021a, 2021b) is a methodology that facilitates exploration of the influences of time over time. It provides a temporal architect

Data-driven analysis of parametrized acoustic systems in the frequency domain

A data-driven method combined with the formulations of boundary integral equations is developed for the frequency-domain analysis of parametrized acoustic systems, arising from the spatial discretization of the linear Helmholtz equation. The method derives surrogate models for the approximation of frequency response functions at selected field points via the construction of neural networks with ra

Thermoregulatory consequences of growing up during a heatwave or a cold snap in Japanese quail

Changes in environmental temperature during development can affect growth, metabolism and temperature tolerance of the offspring. We know little about whether such changes remain to adulthood, which is important to understand the links between climate change, development and fitness. We investigated whether phenotypic consequences of the thermal environment in early life remained in adulthood in t

Insights on macro- and microscopic interactions between Confidor and cyclodextrin-based nanosponges

Imidacloprid is one of the most widely used soluble neonicotinoid insecticide, which is non–volatile and persists in the soil, with hazardous effects on birds, honeybees, and mammals. It is used in both agricultural and veterinary applications, and is found in at least 7% of European topsoils. One of the commercially available formulations is Confidor O–TEQ® that exhibits higher retention, spreadi

Overuse of EEG and ECG in children with breath-holding spells and its implication for the management of the spells

AIM: Breath-holding spells (BHS) are common in children, but evidence-based clinical guidelines are lacking. We investigated a large population-based cohort of BHS patients, to propose a refined description of typical BHS and guidelines for its management.METHODS: In a cross-sectional retrospective study, patients diagnosed with BHS in Southern Sweden 2004-2018 were recruited. Disease characterist