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Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with high hyperdiploidy [51-67 chromosomes] and the t(12;21)(p13;q22) [ETV6/RUNX1 fusion] representing the most frequent abnormalities. Although these arise in utero, there is long latency before overt ALL, showing that additional changes are needed. Gene dysregulation through hypermethylation may be such an event; however
Numerous publications have described the importance of Bone Morphogenetic Protein (BMP) signaling in the specification of hematopoietic tissue in developing embryos. Here we investigate the full role of canonical BMP signaling in both adult and fetal liver hematopoiesis using conditional knockout strategies, since conventional disruption of components of the BMP signaling pathway result in early d
Islet hormone secretion is regulated by a variety of factors, and many of these signal through G protein-coupled receptors (GPCRs). A novel islet GPCR is GPR54, which couples to the Gq isoform of G proteins, which in turn signal through the phospholipase C pathway. Ligands for GPR54 are kisspeptins, which are peptides encoded in the KISS1 gene and also expressed in islet beta-cells. The KISS1 gene
Popular Abstract in Swedish Centralt i avhandlingen är självbiografiskt minne och metaforer. Tre hypoteser framförs: (1) Den dikotomisering av deklarativa långtidsminnet som Tulving föreslagit är inte tillräcklig för att förklara självbiografiskt minne. Istället föreslås en alternativ modell där semantiskt och självbiografiskt minne överlappar varandra och där återupplevelseminnet uppfattas som enThe central topics of the thesis are autobiographical memory and metaphors. Three hypotheses are presented: (1) Autobiographical memory is better understood without dichotomizing the declarative (explicit) long-term memory system into semantic and episodic. An alternative model is proposed in which semantic and autobiographical memory are overlapping and the recollective memory is regarded as a me
Metal matrix composites (MMCs) possess excellent material properties due to the combination of metals and reinforcing phases, yet this reduces their machinability. Numerous studies have shown that, due to the ploughing effect of the cutting tool, the edge effect can directly impact the material removal mechanism and the generation of surface integrity. However, the influence of different cutting-e
The widespread contamination of urban soils by airborne microplastics (MPs) is an emerging environmental issue, particularly in urban allotment gardens with home-grown food. This study investigates the vertical distribution of MP in three such gardens in Berlin, Germany, over 90 days. Soil samples were collected at three depths (0-1 cm, 1–15 cm, and 15–30 cm) and analyzed for MP composition and oc
Groundwater drought, a significant natural disaster in arid and semi-arid regions, contributes to numerous consecutive issues. Due to the inherent complexity of groundwater flow systems, accurately quantifying and describing this phenomenon remains a challenging task. As a result of excessive agricultural development, the Marand Plain in northwestern Iran is experiencing both groundwater drought a
The Gullåkra wetland is located around 5 km south of the modern city of Lund and around 2.7 km east of the important Iron Age settlement of Uppåkra in Scania, southern Sweden. In the 1840s, a remarkable discovery was made in the wetland: a bronze lur dated to c. 1300 BCE, along with a boat and the bones of a large animal offering. As Bronze Age boats are exceedingly rare, this discovery makes the
The proliferation of various data sources in urban and territorial environments has significantly facilitated the development of geospatial artificial intelligence (GeoAI) across a wide range of geospatial applications. However, geospatial data, which is inherently linked to geospatial objects, often exhibits data heterogeneity that necessitates specialized fusion and representation strategies whi
Refractory acute myeloblastic leukemia (AML) is poorly studied. In this study, we characterized primary refractory AML and investigated treatment and outcome in a population-based setting. Based on all AML patients receiving intensive induction therapy at 12 Swedish hospitals from 2011 to 2018 (N = 1221), we identified 306 patients that failed to achieve composite complete remission (CRc) after fi
Introduction: Infective endocarditis (IE) is a challenging diagnosis to suspect and to confirm. The purpose of this study was to clarify how often IE is suspected already on hospital admission, which clinical signs trigger the physicians’ suspicions and to investigate if the empirical treatment is adequate. Methods: A retrospective observational study of cases with definitive IE, during 2018–2019
Brain ischemia is a major cause of neurological dysfunction and mortality worldwide. It occurs not only acutely, such as in acute ischemic stroke (AIS), but also in chronic conditions like cerebral small vessel disease (cSVD). Any other conditions resulting in brain hypoperfusion can also lead to ischemia. Ischemic events can cause blood-brain barrier (BBB) disruption and, ultimately, white matter
Premise: Floral scent is a complex trait that mediates many plant–insect interactions, but our understanding of how floral scent variation evolves, either independently or in concert with other traits, remains limited. Assessing variation in floral scent at multiple levels of biological organization and comparing patterns of variation in scent to variation in other floral traits can contribute to
Coastal protection has evolved from focusing on hard solutions such as breakwaters and groynes to include soft or nature-based solutions (NbS). NbS have been pro- posed as cost-effective means to offer long-term coastal protection and at the same time strengthen coastal resilience and biodiversity. However, projects utilizing NbS for coastal protection have often focused on a single solution and t
Purpose: To describe hand function, and investigate adherence to a rehabilitation protocol and factors associated with upper extremity disability in non-surgically treated proximal phalangeal fractures. Material and methods: In a prospective cohort study, 86 patients (58 women, mean age of 49 years) were assessed at cast removal and 6 weeks follow-up. Adherence was registered in a diary. Factors p
Electroelastic materials possess properties most attractive for the design of smart devices and systems such as actuators and sensors. Typical polymers show changes in shape under the action of an electric field, and vice versa, together with fast actuation times, high strain levels and low elastic moduli. This paper deals with an Ogden model inspired framework for large deformation electroelastic
