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We have investigated the effects of the novel imidazoline compound (+)-2-(2-(4,5-dihydro-1H-imidazol-2-yl)-thiopene-2-yl-ethyl)pyridine (NNC77-0074) on stimulus-secretion coupling in isolated pancreatic alpha- and beta-cells. NNC77-0074 stimulated glucose-dependent insulin secretion in intact mouse pancreatic islets. No effect was observed at less than or equal to 2.5 mM glucose and maximal stimul

By investigating both semi-natural and experimentally implemented pH variation in nutrient-poor sandy grasslands, we examined how soil decalcification may influence the arbuscular mycorrhizal (AM) fungal biomass in plant roots and in the soil, as well as the allocation of carbon (C) to AM fungal biomass. We estimated the amount of AM fungal mycelium, by using the fatty acid 16:1 omega 5, in the ro

Reef biostromes and related facies from the upper part of Wenlock and from Ludlow were investigated in order to account for their formation, their palaeoecology and biology. In the Hemse Group of Ludlow age, all studied biostromes comprise a low diversity fauna where one or few species dominates. These biostromes are divided into Kuppen type biostromes, Grogarnshuvud type biostromes and Sjaustreha

Background: As technology is advancing, so are the possibilities for new data collection methods in research, potentially improving data quality and validity of the results. In Sweden, a system using frequent repeated data collection using text messages, SMS Track, has been used in clinical research for more than a decade. In this paper, compliance with repeated text message questions was examined

A systematic review of chemotherapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for the evaluation of the scientific literature are described separately (Acta Oncol 2001; 40: 155-65). This overview on chemotherapy for epithelial ovarian cancer is based on a total of 176 scientific reports. Five meta-analyses incl

The environmental impact from shipping is driven by the combustion of fossil fuel. It has great potential to be reduced by use of structures in lightweight fibre reinforced polymer composite instead of steel. This has not been possible for ships regulated under SOLAS, since assessment of fire safety of such a fundamental change is complex. The purpose of this thesis has been to provide for the ass

BackgroundInflammation and tyrosine-kinases are known mediators in the pathobiology of cardiovascular disease. Plasma biomarkers reflecting these systems may provide a noninvasive complement reflecting hemodynamics, aiding in clinical decision-making. We therefore aimed to investigate the plasma levels of vascular and inflammatory proteins, and their associations with invasive hemodynamics in adva

BACKGROUND: Medical students navigate a complex landscape of digital tools with potential to enhance learning. The main objectives of the current study were to investigate which digital resources are being used, which background factors are associated with utilization, perceived advantages and disadvantages of different digital resources, and explore future directions.METHODS: Cross-sectional, nat

Background: Keeping the umbilical cord intact the first minutes after delivery is beneficial for both term and preterm infants. However, this may be challenging in caesarean sections (CS) due to lack of mobile resuscitation equipment, maintenance of sterility or concern for excessive maternal blood loss. The objective of this study was to develop and pilot-test extra-uterine placental transfusion

The aim with this Master’s Thesis work was to conduct research about different available authenticators, as well as implementing a multi-factor authenticator into the currently used login-application. The research included biometric authentication technologies, and investigation of how to implement these to create a highly secure and customizable multi-factor authentication for My Axis-accounts fo

Riktlinjer_eng_131105 Department  o f  Serv ice  Management  and     Serv ice  S tud ies     GUIDELINES FOR THIRD-CYCLE EDUCATION IN SERVICE STUDIES Revised approved by the board of the department of service management and service studies 5 November 2013. Reg no SISM 2013/145 The first doctoral students in service studies were admitted in spring 2006. Our ambition at the Department of Service Mana

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/forskarriktlinjer_eng_131105.pdf - 2026-05-30

This study investigates the toxic effect of E(2)nonenal (trans-2-nonenal, T2N) and its conjugate with horse muscle myoglobin (Mb) tested on murine cell line L929 and human cell line A549, as well as the genotoxic effect of these compounds assayed by measuring of micronuclei in human cells K562. It is an aldehyde, which is occurring as the substance responsible for an off flavour in aged beers, but

BackgroundIt remains unclear as to why some individuals at low risk of cardiovascular disease (CVD) develop severe coronary atherosclerosis, while those at high CVD risk may remain free from coronary atherosclerosis.PurposeUsing Coronary Computed Tomography Angiography (CCTA), we aimed to identify factors associated with absence and severe coronary atherosclerosis in subjects from the general popu

ObjectivesThis study investigates the impact of transitioning from restricted to 24/7 access to blood culture cabinets on blood culture processing.MethodA post-hoc retrospective study and a prospective laboratory simulation to evaluate the effects of delayed incubation were conducted. Data analysis evaluated clinical data comparing incubation-to-detection (ITD) and Collection-to-detection (CTD) in

The criteria for Brief Resolved Unexplained Events (BRUE) are used to stratify the risk in infants presenting with apneic episodes. However, these criteria often classify a high proportion of infants as higher risk. This study aimed to investigate the etiology of apneic episodes, particularly those compatible with BRUE, and to assess whether age ≤60 days is associated with serious underlying condi

BACKGROUND: Preoperative anaemia is associated with increased use of blood transfusions, a greater risk of postoperative complications, and patient morbidity. The IRON NOF trial aimed to investigate whether the administration of i.v. iron in anaemic patients during hip fracture surgery reduced the need for blood transfusion and improved patient outcomes.METHODS: This phase III double-blind, random

M i s t r a - s w e c i a | C l i m at e · i m pa C t s · a d a p tat i o n | w w w. m i s t r a - s w e c i a . s e Klimatanpassat sKogsbruK: DrivKrafter, risKer och möjligheter syntes- rapport 2 Mistra-Swecia 2015 Om rapporten ..........................................................................................3 Mistra-SWECIA – forskning om klimat, effekter och anpassning ........5 Inlednin

https://www.hallbarhet.lu.se/sites/hallbarhet.lu.se/files/mistra-swecia_syntesrapport.pdf - 2026-05-30

Objective: To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods: Patients with SLE (ndiscovery cohort=776, nreplication cohort=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs with SLE association (p<5.0×10-8) were analysed. Signal transducer an

Aims/hypothesis: Gene–macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes. Methods: We investigated the influen

Background: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear.Methods: We conducted Mendelian randomization analyses to evalu