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In this paper, we review our efforts to use quantum mechanical (QM) methods to improve free-energy estimates of the binding of drug candidates to their receptor proteins. First, we have tested the influence of various implicit solvation models on predictions of the ligand-binding affinity. The accuracy of implicit solvation models strongly depend on the parameterisation, but also on the magnitude
Background Kenya is facing social and economic problems related to the high unemployment rate the country has suffered since independence. The Kenyan government are placing a lot, if not all, eggs in one basket and betting on entrepreneurship to solve these problem. For entrepreneurship to thrive there needs to be an ecosystem facilitating it and inherent in this ecosystem are support organisation
Background: Aftermarket logistics is important for a manufacturing company to maintain customer satisfaction in the long run. However, the supply chain set for aftermarket parts is equally crucial as the original equipment. Modification or optimization of the logistics systems for slow-moving aftermarket items is inevitable. Sandvik, an engineering company in the mining industry is now interested
Rooted in the environmental movement, the climate movement in Sweden is on the rise and increasingly gaining support in its fight against climate change and its unequal impacts. If successful, the movement can play an important role in changing society. There is increased awareness and proof of the gendered effects of climate change, but awareness of the role of gender in the climate movement seem
Delningsekonomins framväxt under de senaste decennierna är en effekt av digitaliseringen, vilket har fört med sig att arbete via digitala plattformar har tagit plats på arbetsmarknaden. Plattformsarbete kan se ut på många olika sätt beroende på plattformens affärsmodell och denna utveckling har lett till att plattformarnas arbetare har hamnat i en position där det är otydligt om de tillhör kategorThe development of the sharing economy that has taken place in recent decades is an effect of digitalisation, which has led to work being supplied through digital platforms having taken place in the labour market. Platform work can look different in many ways depending on the platform's business model and this development has led the platform's workers to be in a position where it is uncle
Syftet med detta arbete är att ta reda på vad som motiverar byggherrar att välja mer hållbara och framtidssäkra lösningar. Genom att identifiera de trender som byggherrarna känner är mest relevanta samt ta reda på vad de skulle kunna tjäna genom att agera mer hållbart ur de olika hållbarhetsperspektiven kan man hitta de drivkrafter som finns för att bygga mer hållbart. Dessa insikter kan sedan genThe purpose of this study is to find out what motivates developers to choose More sustainable solutions. By identifying trends that are most relevant for developers and find out what developers could gain by acting more futureoriented from the three perspectives of sustainability this study aims to find out what drives developers to build more sustainably. These insights can by comparison with the
The purpose of this study is to look into how middle managers of Swedish LSS housing are balancing their responsibility to provide their clients with good living conditions and their responsibility to fulfill their employees’ right to a good working environment. We conducted one focus group with three middle managers from one municipality participating and then five semi-structured interviews with
In recent years, high-speed railway has been on the upswing in the public debate, as Swedish authorities have affirmed the plans of a high-speed corridor connecting Stockholm, Gothenburg and Malm¨o. The track speed limit is not fully determined, but will be in the range of 250-320 km/h. At these higher speed levels, it is harder to ensure traffic safety and passenger comfort, and dynamic analyses
Today, digital circuits are part of every ones daily life in form of mobile phones, computers, television, smart cards etc. The advent of new technologies such as internet of things, 5G etc. are continuously making the digital circuits more and more complex in design. With this increase in complexity comes the possibility of more bugs in the system. Finding and fixing these bugs is of paramount im
Climate change poses one of the most substantial threats to humanity today global greenhouse gas emissions are not reduced drastically in the near future, it can lead to severe consequences worldwide. To address this issue, global and national goals have been developed which aim to foster climate-neutral societies and industries. Since emissions from the construction industry are shown to have a s
Personalized patient care has gained increasing attention in recent years. Precise drug dosing is critical for patient safety and good clinical outcomes, especially in intensive care units, where patients often are in critical conditions. Such treatments can include stabilizing blood pressure and heart rate or maintaining safe anesthesia levels. However, the inter-patient variability in the drug r
During the last 10 years there has been a constantly increasing demand for micro products and components. The market demand smaller, more functional and better products. The main industries that trigger this demand are the electro-mechanical products. Problem with manufacturing these micro components has occurred with use of conventionally machines. Micro products often demands special working env
Popular Abstract in Swedish Koncentrationer av proteiner i plasma och urin används i ökande utsträckning i diagnostik av njursjukdomar och i studier av den glomerulära barriärens funktion. De viktigaste frågor som behandlats i denna avhandling var: förvaring av urinprover inför efterföljande proteinanalyser, tillämpningar av proteinkoncentrationer i urin och plasma vid hälsa och vid glomerulära (nPlasma and urine concentrations of endogenous proteins are frequently used in the diagnosis of kidney diseases and in studies of glomerular filter function. The main issues addressed in these studies were: storage of urine samples for subsequent protein analysis, use of protein concentrations in urine and in plasma in health and as markers of glomerular diseases, and the application of renal plasm
Background: Assessing RNA quality is essential for gene expression analysis, as the inclusion of degraded samples may influence the interpretation of expression levels in relation to biological and/ or clinical parameters. RNA quality can be analyzed by agarose gel electrophoresis, UV spectrophotometer, or microcapillary electrophoresis traces, and can furthermore be evaluated using different meth
Popular Abstract in Swedish I denna avhandling studeras korruption och mutor som i första hand sociala och moraliska, snarare än ekonomiska, fenomen. Vilka beskrivningar och tolkningar ger svenska och danska biståndsarbetare av sina möten med vardaglig korruption? Hur fördömes, ursäktas eller rättfärdigas användandet av mutor? Går det att tala om en etikett för mutor, och hur ser denna i så fall uIn this dissertation, corruption and bribery are investigated as social and moral, rather than economic, phenomena. The analysis concentrates on the ways in which Swedish and Danish aid workers describe their experiences of everyday or 'petty' corruption. How do they view their encounters with everyday corruption in developing countries? In what ways are bribes condemned, excused, or justified? Wh
In this investigation the possibilities to achieve three different goals for sustainable forestry in the landscape of Stenbrohult have been studied: Preserved biodiversity, balanced nutrient budgets, and a valuable production of timber. The consequences for the landscape and for the different estates were studied. The case study area of Stenbrohult is situated in southern Sweden, and is made up of
In the last decade there has been interest in Homogenous Charge Compression Ignition- HCCI as a way to increase the efficiency of the gasoline engine. The attractive properties are increased fuel efficiency due to reduced throttling losses, increased expansion ratio and higher thermodynamic efficiency. The main drawback of HCCI is the absence of direct combustion timing control. Therefore all the
In this thesis, crystals of yttrium orthosilicate (Y2SiO5) that are randomly doped with another rare-earth element, such as praseodymium (Pr), europium (Eu), or cerium (Ce), are investigated with lasers locked to ultra-stable cavities using the Pound-Drever-Hall locking technique. Many of these rare-earth elements have long-lived 4f-4f transitions, hundreds of microseconds to a few milliseconds, w
The enhancement of heat transfer attributed from rib turbulators relative to the increased pressure drop in the channel is a crucial design parameter. Thus, the design of the truncated ribs (whose length is less than the passage width) provides options to address such cooling requirements when the pressure loss is a critical factor. Considering different types of truncated ribs, mid-truncated ribs
Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. The aims of the present thesis have been to develop and explore a stem cell based vector system for delivery of therapeutic transgenes to experimental gliomas. First, we investig
