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The recast Energy Performance of Buildings Directive introduces binding Minimum Energy Performance Standards for existing non-residential buildings, requiring Member States to identify and renovate the worst-performing segments of their building stock. This study develops and applies an integrated framework for evaluating energy renovation measures in office buildings, addressing building category
This research has explored the role actors from various scales have in the production of Research, Innovation and Smart Specialisation Strategies (RIS3) in the Eastern and Southern Netherlands through its multi-level governance framework. This could be worrying, as the influence from higher-scale actors could weaken RIS3’s ability to create place-based programmes. In order to gain an understanding
Pimavanserin was the first US Food and Drug Administration approved antipsychotic drug that does not block D2 dopamine receptors at therapeutic doses. Pimavanserin is a selective 5-HT2A receptor inverse agonist that reduces the frequency of hallucinations and delusions associated with Parkinson disease. Despite these attributes, pimavanserin prolongs the QT interval at therapeutic doses, limiting
Sverige har uppmärksammats internationellt för sin aktiemarknad av bland annat EU-kommissionen. Samtidigt har farhågor lyfts av akademiker där s.k. emissionsarbitrage beskrivs som ”riskfri överavkastning” för professionella aktörer på bekostnad av vanliga sparare. Syftet med uppsatsen är att under-söka samt analysera gällande normer om god sed på aktiemarknaden som finns beträffande riktade nyemisSweden’s stock market has attracted international attention, including from the European Commission, while researchers have at the same time warned that so called issuance arbitrage can give professional investors “risk free excess returns” at the expense of ordinary savers. This thesis examines the norms of good practice that apply to directed new share issues in order to clarify when such issues
För att underhålla järnvägar på rätt sätt behöver arbetare kunna nå spåret snabbt och enkelt. Detta examensarbete undersöker hur tillgången till järnvägsanläggningar fungerar idag och vilken skillnad servicevägar gör för underhållsarbetet. Studien bygger på intervjuer med åtta personer från Trafikverket och järnvägsunderhållsföretag, data från felrapporteringssystemet Ofelia för åren 2000–2023 samTo maintain railways properly workers need to be able to reach the track quickly and easily. This thesis looks at how access to railway facilities works today and what difference maintenance access roads make for maintenance work. The study is based on interviews with eight people from Trafikverket and railway maintenance companies, data from the fault reporting system Ofelia covering the years 20
Background: Circulating tumor cells (CTCs) carry independent prognostic information in patients with metastatic breast cancer (MBC) on different lines of therapy. Moreover, CTC clusters are suggested to add prognostic information to CTC enumeration alone but their significance is unknown in patients with newly diagnosed MBC. We aimed to evaluate whether longitudinal enumeration of circulating tumo
BACKGROUND: The 2020 European Society of Cardiology (ESC) guidelines recommend using the 0/1-hour and 0/2-hour algorithms over the 0/3-hour algorithm as the first and second choices of high-sensitivity cardiac troponin (hs-cTn)-based strategies for triage of patients with suspected acute myocardial infarction (AMI).PURPOSE: To evaluate the diagnostic accuracies of the ESC 0/1-hour, 0/2-hour, and 0
Vernonia leopoldi (Sch. Bip. ex Walp.) Vatke (Asteraceae) is one of the widely used anti-cancer traditional medicinal plants in Ethiopia, despite the lack of data to support its therapeutic efficacy. Here we describe the isolation of compounds from the plant and the investigation of their cytotoxicity and other bioactivities. We identified the novel sesquiterpene lactone (SL) 11ß,13-dihydrovernoda
Background: Policies that promote aging in place are common in Sweden and many other countries. However, the current housing stock cannot sufficiently accommodate a population aging in place considering how functional capacity and housing needs change as people age. To be suitable for all regardless of their functional ability, housing should be designed or adapted to facilitate the performance of
Background Early life factors may predict cardiovascular disease (CVD), but the pathways are still unclear. There is emerging evidence of an association of early life factors with apolipoproteins, which are linked to CVD. The study objective was to assess the associations between birth variables and adult apolipoproteins (apoA1 and apoB, and their ratio) in a population-based cohort. Methods The L
Hippocampal focal T2 hyperintensities (HT2Hs), also referred to as hippocampal sulcal cavities, are a common finding on Magnetic Resonance (MR) images. There is uncertainty about their etiology and clinical significance. In this study we aimed to describe these HT2Hs in more detail using high resolution 7 Tesla MR imaging, addressing 1) the MR signal characteristics of HT2Hs, 2) their occurrence f
OBJECTIVES: The occurrence of hand and forearm disorders related to vibration exposure, adjusted for relevant background factors, is scarcely reported. We analysed the prevalence of such conditions in a large population cohort, stratified by sex, and associations with exposure to vibrating hand-held tools.DESIGN: This is a retrospective cohort study.SETTING: Individuals in the Malmö Diet and Cance
Worldwide vitamin D insufficiency is remarkably prevalent in both children and adults, including pregnant women. The total amount of the vitamin is best measured by 25-hydroxy-vitamin D (25(OH)D), which is a measurement of total serum cholecalciferol 25 (OH)D3 and ergocalciferol 25(OH)D2. There is a known correlation between maternal and umbilical cord blood (UCB) 25(OH)D; however, whether specifi
In recent years the thermal extremes have become increasingly severe, and it is expected that hot extremes will become twice as frequent if we are unable to limit global warming. The global warming will increase the available energy in certain weather systems making hurricanes more easily reach the development threshold and the increased displacement of precipitation will cause longer and more int
Introduction: FLASH radiotherapy (RT) has emerged as a promising modality, demonstrating both a normal tissue sparing effect and anticancer efficacy. We have previously reported on the safety and efficacy of single fraction FLASH RT in the treatment of oral tumors in canine cancer patients, showing tumor response but also a risk of radiation-induced severe late adverse effects (osteoradionecrosis)
Purpose: Although tumor infiltrating lymphocytes (TIL) assessment has been acknowledged to have both prognostic and predictive importance in triple negative breast cancer (TNBC), it is subject to inter and intra-observer variability that has prevented widespread adoption. Here we constructed a machine-learning based breast cancer TIL scoring approach and validated its prognostic potential in multi
Background: Despite accumulating evidence of an association between air pollution and renal disease, studies on the association between long-term exposure to air pollution and renal function are still contradictory. This study aimed to investigate this association in a large population with relatively low exposure and with improved estimation of renal function as well as renal injury biomarkers. M
Background: Severe left-sided cardiac obstructions are associated with high morbidity and mortality if not detected in time. The correct prenatal diagnosis of coarctation of the aorta (CoA) is difficult. Fetal cardiac magnetic resonance imaging (CMR) may improve the prenatal diagnosis of complex congenital heart defects. Flow measurements in the ascending aorta could aid in predicting postnatal Co
Introduction: Although figure skating attracts several hundred thousand participants worldwide, there is little knowledge about physical health and sports injuries among young skaters. The present study aimed to describe the health status of a geographically defined Swedish population of licensed competitive figure skaters and to examine injury determinants. Methods: All licensed competitive skat
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
