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In this 24-month follow-up of a phase II study in patients with castration-resistant prostate cancer (CRPC) and bone metastases, radium-223 (4 injections of 50 kBq/kg every 4 weeks [n = 33]) improved median overall survival vs. matching placebo (n = 31) (65.3 vs. 46.4 weeks, respectively; log-rank P = .056), with no long-term safety concerns. Data suggest that treatment of bone disease with radium

Popular Abstract in Swedish Denna avhandling i tysk språkvetenskap behandlar en särskild typ av meningar i dagens tyska: påståendesatser med det finita verbet i början. Denna typ har hittills knappast uppmärksammats av forskningen; en av anledningarna till detta är att den oftast förekommer i talat språk. Den vanliga ordföljdsregeln i tyskan är att verbet står på andra plats i huvudsatsen, på sisThe aim of this thesis is to describe and explain independent declarative clauses in German which have the finite verb in absolute clause-initial position. They are called verb-first declarative clauses. It is shown that this type of clause can be found in a variety of Germanic languages. There is evidence suggesting that this is a very old type with roots in ancient Indo-European. It has thus ex

Popular Abstract in Swedish Radiojodbehandling av sköldkörteln är den vanligaste radiofarmakaterapin. För att beräkna aktiviteten 131I som krävs för att ge en viss stråldos till sköldkörteln behöver sköldkörtelns massa och den individuella biokinetiken bestämmas. Biokinetiken består vanligtvis av det individuella upptaget av jodid och den biologiska halveringstiden av jod i sköldkörteln. Den bioloRadioiodine therapy of hyperthyroidism is the most frequently performed radiopharmaceutical therapy. To calculate the activity of 131-I to be administered for giving a certain absorbed dose to the thyroid, the mass of the thyroid and the individual biokinetic data, normally in the form of uptake and biologic half-time, have to be determined. The biologic half-time is estimated from several uptake

A double-blind, randomised, parallel group, multicentre, multinational study compared the effects of 12 months' treatment with lisinopril (10-20 mg once daily) or nifedipine retard tablets (20-40 mg twice daily) in 239 males (aged 18-75 years) and 96 post-menopausal females (aged 40-75 years). They all had a history of clinically stable type II diabetes > 3 months, microalbuminuria and early diabe

Time domain reflectometry (TDR) is a widely used method for measuring the dielectric constant (K-a) and bulk electrical conductivity (sigma(a)) in soils. The TDR measured sigma(a) and K-a can be used to calculate the soil solution electrical conductivity, sigma(w.) The sigma(w), in turn, can be related to the concentration of an ionic tracer. Several models of the sigma(w)-sigma(a)-K-a relationshi

Background: Circulating tumor cells (CTCs) carry independent prognostic information in patients with metastatic breast cancer (MBC) on different lines of therapy. Moreover, CTC clusters are suggested to add prognostic information to CTC enumeration alone but their significance is unknown in patients with newly diagnosed MBC. We aimed to evaluate whether longitudinal enumeration of circulating tumo

Objective To date, the major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors and are estimated to control more than 30 candidate miRNAs among night shift workers.Materials and Methods RNA was extracted from plasma samples of 110 night and 90day shift worker

Background: Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear. Objectives: This study sought to compare the effectiveness of lower extremity compression with thigh-high ECS vs sham stockings for the prevention of VVS recurr

Arbetet är utfört åt skogsforskningsstationen Mógilsá som ligger strax norr om Reykjavik. Forskningen inom Mógilsá bedrivs inom delar av eller för hela Island med inriktning inom exempelvis dendrokronologi, proveniensförsök, och studier av insekter. Sedan 1900-talets början har inplantering av exotiska trädarter blivit allt vanligare och i en allt större skala. Syften med inplanteringen är bland aThis study was made in an attempt to give the forest research centre Mógilsá a produced tetratherm map and a better understanding of how topography and temperature influence the growth of two tree species. The digital tetratherm map model, covering the northern part of Iceland, was developed to investigate the correlation between tetratherm and the growth of Picea sitchensis and Larix (sukaczewii

Immigrants from the Middle East to Sweden have a twice as high prevalence of type 2 diabetes (T2D) and obesity as native-born Swedes. Both obesity and T2D have been linked to increased incidence of cancer, cardiovascular disease (CVD) and all-cause mortality (ACM); however, data on differences between ethnicities are scarce. In a population-based cohort we aimed to study the impact of Middle Easte

Ecosystem-based approaches for climate change adaptation are promoted at international, national, and local levels by both scholars and practitioners. However, local planning practices that support these approaches are scattered, and measures are neither systematically implemented nor comprehensively reviewed. Against this background, this paper advances the operationalization of ecosystem-based a

Under the current accounting systems, emissions produced when biomass is burnt for energy are accounted as zero, resulting in what is referred to as the 'carbon neutrality' assumption. However, if current harvest levels are increased to produce more bioenergy, carbon that would have been stored in the biosphere might be instead released in the atmosphere. This study utilizes a comparative approach

Objectives To evaluate in a prospective, randomized clinical trial (RCT), symptom response among obese knee osteoarthritis (OA) patients following a feasible. intensive weight-loss program for 16 weeks Methods Eligible patients were obese [body mass index (BMI)> 30 kg/m(2)], >50 years old, with primary knee OA Participants were randomized to either a very-low-energy diet (VLED) or a low-energy die

BACKGROUND: Critically ill newborn infants undergo a variety of painful procedures or experience a variety of painful conditions during their early life in the neonatal unit. In the critically ill paediatric and neonatal population, clonidine is prescribed as an adjunct to opioids or benzodiazepines aiming to reduce the doses of these drugs that are required for analgesia or sedation, or to facili

OBJECTIVE: To evaluate the feasibility of a randomized controlled pilot study with lifestyle-promoting text messages as a treatment for hypertension in primary care.DESIGN: Randomized controlled pilot trial.SETTING: Three primary health care centers in southern Sweden.SUBJECTS: Sixty patients aged 40-80 years with hypertension were included.MAIN OUTCOME MEASURES: Feasibility of the pilot study, i.

Importance: Congenital heart disease (CHD) is the most common congenital malformation in humans worldwide. Circulating cardiovascular biomarkers could potentially improve the early detection of CHD, even in asymptomatic newborns. Objectives: To assess the performance of a dried blood spot (DBS) test to measure the cardiovascular biomarker amino terminal fragment of the prohormone brain-type natriu

The evolution of phases over time during freezing and thawing of unconfined Na- and Ca-montmorillonites (Wyoming, MX-80) was studied with time-resolved synchrotron X-ray diffraction. The clay samples were: (i) powder equilibrated to ambient atmosphere and (ii) pastes of 30 mass% montmorillonite in pure water. The phases were characterised in-situ using a stream of nitrogen gas for temperature cont

Atrial. fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Neither the natural history of AF nor its response to therapy is sufficiently predictable by clinical and echocardiographic parameters. The purpose of this article is to describe technical aspects of novel electrocardiogram (ECG) analysis techniques and to present research and clinical applications of these m

PURPOSE: To investigate the incidence and causes of visual impairment in children born prematurely in Finland from 1972 through 1989, and to determine what conditions and factors were associated with its occurrence. DESIGN: Retrospective, cross-sectional study. SUBJECTS: All visually impaired individuals from 0 to 17 years of age who had been born at fewer than 37 gestational weeks in Finland from

In this article the organization and functional details of the extracellular matrix, with particular focus on cartilage, are described. All tissues contain a set of molecules that are arranged to contribute structural elements. Examples are fibril-forming collagens forming major fibrillar networks in most tissues. The assembly process is regulated by a number of proteins (thrombospondins, LRR-prot