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Introduction Aniridia (iris more or less missing), is a congenital, dominant, inherited, serious and sight-threatening disease, most often appearing as an isolated eye disorder. It is caused by mutations in the PAX6 gene, the master gene of the development of the eye. Typically, Aniridia causes severe visual impairment. In addition to glare caused by the iris defect, underdevelopment of the macula
The aim of this study was to achieve realistic levels of two different types of aerosols commonly abundant in indoor environments in an experimental chamber intended for human exposure studies and aerosol characterization. The aerosols chosen were particles from candle lights (in particle number dominated by inorganic water soluble particles) and from ozone-terpene reactions (organic particles). T
Background: The widening socioeconomic gap in smoking during pregnancy remains a challenge to the Swedish antenatal care services. However, the influence of cultural factors in explaining the socioeconomic differences in smoking during pregnancy is not clear among the immigrant women. The aim of this study was to investigate whether the development of smoking prevalence among pregnant immigrant wo
Denna undersökning utreder den diskrepans som finns mellan 40 a § URL och 3 § 2 st LAU. De två paragraferna kan framkalla motsägelsefulla situationer för arbetsgivare och arbetstagare när både upphovsrätt och patenträtt kan ges ett datorprogram. Ämnet berör till stor del det immaterialrättsliga området, men ses utifrån ett arbetsrättsligt perspektiv. Denna typ av undersökning är intressant då de oThis study investigates the discrepancy between 40 a § URL and 3 § 2 st LAU. The two sections can produce contradictory situations for employers and employees when both copyright and patent law can be given a computer program. The subject is mainly linked to intellectual property law, but is viewed from a labor law perspective. This type of study is interesting, because the different fields of law
OBJECTIVE: This systematic review aimed to assess the clinical outcomes of branched endovascular aneurysm repair (BEVAR) with inner branches (iBEVAR) and inner/outer branches (oBEVAR).DATA SOURCES: A systematic literature review was performed using the electronic bibliographic databases MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Library up to May 2024.REVIEW METHODS: The review was
The minority stress model has become a well-used framework to explain and analyse health among LGBTQ people, and specifically among transgender and gender-diverse people (TGD), when it is sometimes called ‘the gender minority stress model’. Scholars have argued the need for critical discussions about some of the assumptions underlying the gender minority stress model and how it has been used and d
Migration patterns of Nordic Greylag Geese Anser anserwere studied by means of neck-collaring. A total of 4173birds (738 breeders, 1999 goslings and 1436 moulters;most moulters subsequently identified as belonging to aspecified breeding population) was marked throughoutNorway, Sweden, Denmark and Finland during 1984–1994. This report is based on observations made up to 30June 1995. In general, Nor
Background Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. Objectives This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysi
This paper is about line search for the generalized alternating projections (GAP) method. This method is a generalization of the von Neumann alternating projections method, where instead of alternating projections, relaxed projections are alternated. The method can be interpreted as an averaged iteration of a nonexpansive mapping. Therefore, a recently proposed line search method for such algorith
BACKGROUND: It is unclear whether estrogen receptor (ER)-status of first primary breast cancer is associated with risk of metachronous (non-simultaneous) contralateral breast cancer (CBC), and to what extent endocrine therapy affects this association.METHODS: We studied the effect of ER-status of the first cancer on the risk of CBC overall, and for different ER-subtypes of CBC, using a large, popu
Background: Chronic suppurative otitis media (CSOM) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions. Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas. T
Photosynthesis by terrestrial plants is the main driver of the global carbon cycle, and the presence of actively photosynthesizing vegetation can now be observed from space. However, challenges remain when translating remotely sensed data into carbon fluxes. One reason is that the Fraction of Absorbed Photosynthetically Active Radiation (FAPAR), which documents the presence of photosynthetically a
Gravitational instabilities play an important role in galaxy evolution and in shaping the interstellar medium (ISM). The ISM is observed to be highly turbulent, meaning that observables like the gas surface density and velocity dispersion depend on the size of the region over which they are measured. In this work, we investigate, using simulations of Milky Way-like disc galaxies with a resolution
Objective/background: Mycotic aortic aneurysms are rare, life threatening, and complex. This nationwide study aimed to assess outcome after repair of mycotic thoracic aortic aneurysms (MTAAs). Methods: Patients treated in Sweden for MTAAs between 2000 and 2016 were identified in the Swedish vascular registry (2010–16) and local patient registries (2000–09). Primary outcome was survival, and second
Tensins are large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins. Tensins are multidomain proteins consisting of homologous C1, PTPase, C2, SH2 and PTB domains. Full-length Tensin proteins can undergo cleavage inside cells, thus yielding domains in isolation that may have discrete subcellular localisations and downstream effects. We expressed dif
INTRODUCTION: Branched iliac stent-grafts (bSG) have recently been developed in order to preserve internal iliac artery (IIA) flow in patients with aneurysmal or short common iliac arteries. The aim of this study is to evaluate a single-center experience with bSG for the IIA. METHODS: Twenty-two male patients (70 (IQR 65-79) years old) underwent EVAR with 23 bSG (1 bilateral repair) between Septem
Two-photon excited fluorescence spectroscopy has been performed at a microscopic scale in combination with normal, white-light microscopy. This gave simultaneously a spectral resolution of 20 nm and a temporal resolution of 20 ps, from a volume element less than 5 mu m in all three dimensions. The sample was excited with the light from a continuously mode-locked Ti:sapphire laser that was focused
Aims: Use of left ventricular assist devices (LVADs) in older patients has increased, and assessing outcomes in older LVAD recipients is important. Therefore, this study aimed to investigate associations between age and outcomes after continuous-flow LVAD (cf-LVAD) implantation. Methods and results: Cf-LVAD patients from the multicentre European PCHF-VAD registry were included and categorized into
BACKGROUND: The use of viscoelastic tests is becoming increasingly popular. There is a paucity of validation of the reproducibility of varying coagulation states. Therefore, we aimed to study the coefficient of variation (CV) for the ROTEM EXTEM parameters clotting time (CT), clot formation time (CFT), alpha-angle and maximum clot firmness (MCF) in blood with varying degrees of coagulation strengt
In this paper we show that several metals, elements and energy resources are about to run into scarcity within the next decades, and most elements within some centuries. A new global systems model was assembled to analyse this scarcity as a continuation of the model used in the Limits-to-Growth World3 model. We show that this scarcity will lead to “peak wealth”, “peak population”, “peak costs”, “p
