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Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma

Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3

Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland

This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

European Obspack compilation of atmospheric carbon dioxide data from ICOS and non-ICOS European stations for the period 1972-2023; : obspack_co2_466_GLOBALVIEWplus_v8.0_2023-04-26

This data package contains high accuracy CO2 dry air mole fractions from 58 ICOS and non-ICOS European observatories at in total 132 observation levels, collected by the ICOS Atmosphere Thematic Centre (ATC) and provided by the station contributors. The package is part of the Globalviewplus v8.0 data product, released in 2022 and is intended for use in carbon cycle inverse modeling, model evaluati

Natural Radiative Lifetimes of Some Excited Bi I Levels Belonging to the 6p^(2)7s and the 6p^(2)6d Configurations Measured by the Hanle Method

The natural radiative lifetimes of some excited Bi I levels belonging to the 6 p 2 7 s and the 6 p 2 6 d configurations have been determined by analyzing Hanle depolarization curves obtained in an atomic beam experiment on the 100% abundant isotope Bi 209 ( I =9/2). Taking the exciting light spectral distribution into account the following values for the lifetimes have been obtained: ##IMG## [http

Summer of the Arts : 19 July 2024 – 26 January 2025

The interdisciplinary cooperation project »Summer of the Arts« showed works by the 2022/2023 and 2023/2024 recipients of the Villa Massimo’s German Rome Prize in eight institutions in Stuttgart. The Staatsgalerie Stuttgart presented the art created by Yael Bartana, Manaf Halbouni, and Bjørn Melhus during their stays in Rome in dialogue with works from the Staatsgalerie collection.