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Three scenarios for globalisation. A view from cultural semiotics

Three scenarios for globalisation. A view from cultural semiotics Göran Sonesson Using the concept of the auto-model, this text describes global society as a device people use to understand their relation to other cultures. Three scenarios are analysed in terms of a model each : first, we consider the hypertrophy of the Internal Other, which results from the displacements of sizeable populations

Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance

Metabolomic screening of fasting plasma from nondiabetic subjects identified alpha-hydroxybutyrate (alpha-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint markers of insulin resistance (IR) and glucose intolerance. To test the predictivity of alpha-HB and L-GPC for incident dysglycemia, alpha-HB and L-GPC measurements were obtained in two observational cohorts, comprising 1,261 nondiabetic

Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma

Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3

{2,6-bis[(diphenylphosphino)methyl]-phenyl}chloroplatinum(II)

The title compound, [PtCl(C32H27P2)], has a pseudo-square-planar coordination geometry around the Pt atom with the P,C,P'-tridentate ligand forming two five-membered rings that are tilted with respect to the coordination plane. The two Pt-P the Pt-Cl and the Pt-C distances are 2.2794 (9)/2.2749 (10), 2.3831 (10) and 2.002 (3) Angstrom, respectively.

Testicular-cancer survivors experience compromised language following chemotherapy: Findings in a Swedish population-based study 3-26 years after treatment

Background. Studies suggest an increased risk for compromised cognitive function among cancer survivors. It is unclear to what extent chemotherapy is the cause and how the dysfunction, when present, affects everyday life. The objective was to study self-reported behaviours that may depend on cognitive function, among testicular-cancer survivors who received various cycles of cisplatin-based chemot

rac-4,8-Divinylbicyclo[3.3.1]nonane-2,6-dione

The title compound, C13H16O2, is a chiral bicyclic structure composed of two fused cyclohexane rings possessing both boat and chair conformations. The molecules are packed in enantiopure columns which are pairwise linked forming an overall racemic solid; within the column pairs the packing is governed by weak dipole-dipole interactions stemming from stacked carbonyl functionalities (COcentroid-COc

[2,6-Bis(di-tert-butylphosphinomethyl)phenyl-kappa P-3,C-1,P '](trifluoroacetato)palladium(II)

The Pd-II atom in the title compound, [Pd(C2F3O2)(C24H43P2)], adopts a distorted square-planar geometry with the P atoms in a trans arrangement, forming two five-membered chelate rings. Four intramolecular C-H center dot center dot center dot O hydrogen bonds occur. The crystal packing reveals one weak intermolecular C-H center dot center dot center dot O hydrogen bond, which self-assembles the mo

MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT applied for Dosimetry of Radiopharmaceutical Therapy.

Accuracy of absorbed dose calculations in personalized internal radionuclide therapy is directly related to the accuracy of the activity (or activity concentration) estimates obtained at each of the imaging time points. MIRD Pamphlet No. 23 presented a general overview of methods that are required for quantitative SPECT imaging. The present document is next in a series of isotope-specific guidelin

Streptococcus pyogenes secreted enzymes interacting with the human host

Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that