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Developing integrated downstream processes for next-generation biologics

Manufacturing of biopharmaceuticals is a costly and time consuming process due to its inherent complexity and variability. The downstream process is the most expensive part and it involves multiple non-trivial steps. Continuous integrated manufacturing is a new concept that is encouraged by authorities. The advantages include uninterrupted operation, automation, consistent product quality, lower r

Methods for measurement of solubility and dissolution rate of sparingly soluble drugs

The drug discovery process has changed dramatically during the last decade. The development of technologies such as combinatorial chemistry has introduced methods to synthesize massive numbers of new diverse compounds. This, combined with High-Throughput Screening techniques HTS, makes it possible in vast numbers to examine the potency in vitro of new compounds. This kind of approach is highly suc

Evaluation of SharePlan

Introduction: SharePlanTM is a new type of treatment planning system produced by RaySearch Laboratories AB for TomoTherapy Inc. SharePlan enables transfer of treatment plans generated with the TomoTherapy Hi∙Art® system to plans deliverable at conventional linacs. The main reason for this is to ensure continuous patient treatment if the TomoTherapy unit “goes down”, e.g. at clinics with only one T

Intuitive Instruction of Industrial Robots : A Knowledge-Based Approach

With more advanced manufacturing technologies, small and medium sized enterprises can compete with low-wage labor by providing customized and high quality products. For small production series, robotic systems can provide a cost-effective solution. However, for robots to be able to perform on par with human workers in manufacturing industries, they must become flexible and autonomous in their task

On Low-Cycle Fatigue

Popular Abstract in English The present work deals with fracture in structures which are exposed to relatively few cycles of static loading during their life-time (maximum some ten thousand). Structures exposed to nearly monotonic loading are rare, except for such loaded mainly by their own weight. In spite of this fact, fracture mechanic methods developed for monotone loading are commonly used onThe experimental results presented confirm the anticipation that it is extremely important not to confuse the concept of 'static loading' with the one of 'monotonic loading'. In principle three different crack configurations were investigated in: edge-cracks, internal flaws and surface cracks. The results showed that the same calculation method could be used for all the investigated crack types. T

Light, activity, and sleep: Design and usability evaluations of a web-based course supporting changes to routines and the home

While research indicates that indoor lighting, exposure to daylight, physical activity, and sleep interact to influence functioning, mood, and daily rhythm, strategies are needed to support behavioral changes among older adults who often spend more time at home after retirement. The objective was to design a web-based course to encourage behavior change related to light, activity, and sleep. Groun

Bringing human diversity into design processes through empathic modelling

Most products are developed while adapting to requirements from industrial production and logistics. To break that trend and design for people, we suggest focusing on those who put the strongest demands on the final solution. They cannot compensate for bad design solutions and are thereby, like sniffing dogs, guiding designers to meet peoples’ needs. We always use a combination of empathic modelli

Investigating self-compatibility of diploid potato populations

Are potatoes, grown from seeds, the future? Did you know that you can grow potato plants from seeds? A potato plant has two ways to propagate itself; by the all known potato that we love to eat and by seeds that are grown in tomato-like berries above the ground. These seed producing potato plants that are as well diploid (two copies of every chromosome) instead of conventional tetraploid (4 copie

Exploring how Individual Characteristics Relate to Use of Generative AI for Schoolwork and Emotional Regulation in Early Adolescence: Ties to Executive Functions, Internalizing Symptoms and Academic Achievement

ChatGPT och andra generativa Artificiell Intelligens (AI) -verktyg har nyligen fått betydande uppmärksamhet, och deras användning i skolarbete fortsätter att sprida sig globalt. Även om effektiviteten och säkerheten hos dessa verktyg inte är väl grundade i vetenskapen, tyder initiala resultat på deras popularitet i den svenska tonårspopulationen både för skolarbete och emotionell reglering. Hur anChatGPT and other generative AI tools have received considerable attention recently and their usage in schoolwork continues to expand globally. Even though the effectiveness and safety of these tools are not well grounded in science, initial findings suggest their popularity among the Swedish adolescent population for both schoolwork and emotional regulation. Whether this trend is the same in a yo

Easy to do business - Or is it?

The Ease of Doing Business index, published by the World Bank, ranks countries by how easy it is to do business in them, with the goal of encouraging reforms favoring firms and economic prosperity. However, it is not guaranteed that the index is properly constructed to measure what it aims to measure, and the placement of certain countries on the index, as well as the results from a number of prev