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The quantification of species along environmental gradients has long been the subject of study regarding natural plant communities and, more recently, ecosystems disturbed by anthropogenic emissions of eutrophying and acidifying substances. We studied 527 sites in southern Swedish deciduous forests divided into two regions, with mean nitrogen depositions of 17 and 9 kg ha(-1) y(-1). The higher dep
Lately, evidence for early-Holocene emerging sedentism has been suggested among foragers in Northern Europe. The core of this suggested sedentism lies in the increasing dependency on large-scale fishing and mass consumption of fish and a territorial behaviour associated with access to the best fishing locations. This territoriality might also be associated with increasing numbers of people settlin
Issue management in market-driven software projects is constantly under time pressure. A limited set of developers must share their time between developing features for the next release and resolving reported issues. Project managers need to find the appropriate balance between a high quality product and fast time to market. We study a telecom company in Sweden developing embedded systems for a co
Climate change and human impact play a huge role in the sustainability and development of ecosystems and the services they offer to societies over temporal and spatial scales. Fossil pollen-based estimates provide unique information on past land cover change, but to date there are not many methods able to create spatially continuous maps and have a fine scale of land cover changes inferred from po
Popular Abstract in Swedish Min avhandling har fokuserat på att öka förståelsen för den ovanliga, allvarliga genetiska sjukdomen infantil malign osteopetros (IMO), med målet att utveckla genterapi som en ny behandlingsform för sjukdomen. IMO finns redan vid födseln och orsakas av att osteoklasterna, cellerna ansvariga för nedbrytning av ben, inte fungerar. Sjukdomen kan orsakas av flera olika gendThis thesis focuses on developing stem cell targeted gene therapy for the severe hereditary disorder Infantile Malignant Osteopetrosis (IMO) as well as increasing the understanding of how the genetic defect present in IMO affects the hematopoietic stem cells and hematopoiesis in general. IMO is a rare congenital disorder associated with an increased number of non-functional osteoclasts and the a
Postal address P.O. Box 117, 221 00 Lund, SWEDEN Visiting address Sandgatan 13A, Lund Telephone +46 46 222 00 00 E-mail malin.schatz@sam.lu.se Website www.sam.lu.se/en Facul ty Board Instructions and procedures for programme evaluations by external experts at the Faculty of Social Sciences Introduction Lund University’s Policy for quality assurance and quality enhancement of education at Lund Univ
In recent years, hydrogels have been demonstrated as simple and cheap additives to improve the optical properties and material stability of organometal halide perovskites (OHPs), with most research centered on the use of hydrophilic, petrochemical-derived polymers. Here, we investigate the role of a peptide hydrogel in passivating defect sites and improving the stability of methylammonium lead iod
Human carbonyl reductase 1 (CBR1), that is one of the enzymes responsible for the reduced efficiency of treatments by the antineoplastic agents anthracyclines, was functionally expressed in Saccharomyces cerevisiae. CBR1 was purified and kinetically characterised using daunorubicin as substrate. CBR1-catalysed reduction of daunorubicin followed an apparent Michaelis-Menten kinetics with K-M = 85.2
Abstract in UndeterminedRelevant source area of pollen (RSAP) and pollen productivity for 11 key taxa characteristic of the pasture woodland landscape of the Jura Mountains, Switzerland, were estimated using pollen assemblages from moss polsters at 20 sites. To obtain robust pollen productivity estimates (PPEs), we used vegetation survey data at a fine spatial-resolution (1 x 1 m(2)) and randomize
We have studied the convergence of QM/MM calculations with respect to the size of the QM system. We study a proton transfer between a first-sphere cysteine ligand and a second-sphere histidine group in [Ni,Fe] hydrogenase and use a 446-atom model of the protein, treated purely with QM methods as a reference. We have tested 12 different ways to redistribute charges close to the junctions (to avoid
Guidelines and procedures for programme evaluations by external experts at the Faculty of Social Sciences Page 1 of 13 Faculty Board DECISION Reg. No. STYR 2024/2571 Date 2024-11-21 Guidelines and procedures for programme evaluations by external experts at the Faculty of Social Sciences This decision applies to evaluations initiated from 2025 onwards. Introduction The guidelines build upon the Qua
Popular Abstract in English Proteins are a big biological molecules that help cells to function. Proteins play important roles in all vital processes of the living cell, transporting molecules, speeding up chemical reactions, supporting structure of other proteins and the cell, helping the cell to move. Various disease-causing agents (e.g. bacteria and viruses) are constant threat to us. It is thMost drugs act on biomacromolecules. The Cost of developing new drugs is very high. A method to accurately predict binding affinities would be very useful. We have studied molecular mechanics with generalised Born and surface--area solvation (MM/GBSA) and alchemical free energy perturbation methods (FEP) for use in calculations of ligand binding energies. For the MM/GBSA method we have tested: Ca
Enzymes of the xanthine oxidase family are among the best characterized mononuclear molybdenum enzymes. Open questions about their mechanism of transfer of an oxygen atom to the substrate remain. The enzymes share a molybdenum cofactor (Moco) with the metal ion binding a molybdopterin (MPT) molecule via its dithiolene function and terminal sulfur and oxygen groups. For xanthine dehydrogenase (XDH)
Proton Beam Therapy (PBT) is an increasingly utilised modality for treating tumours by utilising the physical properties of accelerated proton beams. This review explores the development of PBT, its dosimetric advantages over conventional x-ray-based radiotherapy, and the rationale behind its use in paediatric oncology whilst simultaneously considering the various challenges associated with its de
Per Mårtensson Tillämpning av SCORE-metoden på f.d BT Kemis södra område Syftet med denna uppsats har varit att tillämpa multikriteriaanalysen SCORE för att utreda vilket av tre åtgärdsalternativ som mest gynnar hållbar utveckling vid den kommande saneringen av det södra området på BT Kemi – samt att även utvärdera själva SCORE-metoden. Intresset för hållbar sanering har ökat i takt med att Remediation of contaminated sites may cause adverse negative effects like usage of non-renewable resources, high monetary cost, air emissions and an increased risk of accidents. Therefore, interest in sustainable remediation has increased in recent years. The aim with sustainable remediation is to integrate a holistic perspective on remedial projects and find the alternative that is considered bes
Abstract. This study presents a comprehensive assessment of the meteorological conditions and atmospheric flow during the Lagrangian-type "Hill Cap Cloud Thuringia 2010" experiment (HCCT-2010), which was performed in September and October 2010 at Mt. Schmücke in the Thuringian Forest, Germany and which used observations at three measurement sites (upwind, in-cloud, and downwind) to study physical
This study sheds light upon how memes about rioting in present-day Belfast are read by their audiences. As such, it answers to a distinct research gap in the meme studies literature, which has mostly shied away from in-depth engagements with audiences, favouring instead the intertwined concepts ‘imagined audience’ and the ideological ‘directionality’ of memes. Drawing on semi-structured interviews
Anthropogenic activities threaten many wildlife populations by increasing mortality rates, making it crucial to identify the locations and causes of mortality to inform conservation actions. Technological advancements, such as GPS satellite tracking, enable precise recording of wildlife movements. High-resolution data from such devices can facilitate rapid carcass recovery and provide insights int
Ground level ozone [ozone] is considered a harmful air pollutant but there is a knowledge gap regarding its long term health effects. The main aim of this study is to develop local Land Use Regression [LUR] models that can be used to study long term health effects of ozone. The specific aim is to develop spatial LUR models for two Swedish cities, Umea and Malmo, as well as a temporal model for Mal
Non-covalently molecularly imprinted polymers (MIPs) for beta(2)-amino acids were prepared for the first time. N-(2-chlorobenzyloxycarbonyl)-(R)-beta(2)-homophenylalanine (N-2-ClZ-(R)-beta(2)-HPhe)was imprinted with methacrylic acid (MAA) and/or 4-vinylpyridine (4-VPy) as the functional monomers, with ethylene glycol dimethacrylate ( EDMA) as the cross-linker. The MIPs made with different ratios o
