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In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically relevant genes in hereditary breast/ovarian cancer (HBOC) and Lynch syndrome.
[Alsnö stadga 1279 – DS 799; SDHK 1122] MAGNUS sweæ konungær oc gøtæ mæð guz naðum. sændir allum þem mannum ær þættæ breff se oc horæ. guðz kwæðiu oc sinæ nað. Vir kyænnums þær viþær. at aff þæt walð guð hawir hos .i. skippæt. hører hos þæt at huxæ oc stadwæ. ær guz vari heðþer. oc þerræ mannæ þærwir sum rikit byggiæ. 1. En hær hawir wærit .i. wart riki en usiðþær længi. at allir þær mæn vm rikit
https://www.nordlund.lu.se/fileadmin/user_upload/fornsvenska/rtf/Alsno-1279.rtf - 2026-06-11
Fourteen tree-ring chronologies developed from 788 peatland Scots pines sampled at sites in Estonia, Belarus and Sweden were compared for common growth trends and possible links to regional climate dynamics. Several synchronous growth release events were detected, especially during the 1910s, 1930s, and around 1970 and 1990, indicating that hydrological shifts and associated tree growth responses
There are many projects in Mozambique for poverty reduction. One of these projects is funded by Millennium Challenge Account (MCA) and is aimed to install a total of 600 rural water points in the provinces of Nampula and Cabo Delgado. Each water point consists of a drilled well, a water pump and a communal washing basin. Vertical Electrical Sounding (VES) was used for assessing the uitability of
With their highly sensitive visual systems, the arthropods have evolved a remarkable capacity to orient and navigate at night. Whereas some navigate under the open sky, and take full advantage of the celestial cues available there, others navigate in more difficult conditions, such as through the dense understory of a tropical rainforest. Four major classes of orientation are performed by arthropo
In this thesis, the GW approximation (GWA, Green's function G times screened interaction W) and the Hubbard I approximation (HIA) are combined in a non-self-consistent one-shot calculation to determine the electronic structure of a one-dimensional strongly-correlated model. The scheme was chosen to incorporate both screening effects through the GWA and strong on-site correlations through the a
Summary: The Fracture Liaison Service (FLS) Consensus Meeting endorsed by the International Osteoporosis Foundation (IOF), Asian Federation of Osteoporosis Societies (AFOS), and Asia Pacific Osteoporosis Foundation (APOF) was hosted by the Taiwanese Osteoporosis Association on October 14, 2017. International and domestic experts reviewed the 13 Best Practice Framework (BPF) standards and concluded
The effect of future changes in temperature and precipitation patterns on arctic ecosystem functioning is often assessed using state-of-the-art ecosystem models. Many models however lack detailed representation of wintertime processes, as pointed out by recent studies (Wang et al. 2016, Slater and Lawrence 2013). This bias may influence the derived outputs, such as soil temperature, permafrost ext
Pleural and tracheal injuries remain significant problems, and an easy to use, effective pleural or tracheal sealant would be a significant advance. The major challenges are requirements for adherence, high strength and elasticity, dynamic durability, appropriate biodegradability, and lack of cell or systemic toxicity. We designed and evaluated two sealant materials comprised respectively of algin
The study investigates how the Best Interests of the Child principle in the UN Children's Rights Convention (Article 3) has been adapted in custody disputes in Egypt, Sweden, and Uzbekistan. Although the Convention on the Rights of the Child offers a common normative benchmark, divergent legal cultures shape its domestic meaning: Egypt is governed by religious and state legal norms intersecting wi
LUMES Lund University International Master's Programme in Environmental Science M.Se. Thesis Investigating Dynamies of son Acidifieation: Applieation of the biogeoehemieal model SAFE to two sites in the Republie of Croatia by Luka Traven IvanaDezmana10 51000Rijeka Croatia Tel: +38551214174 E-mail:lukatraven@yahoo.com Supervisor: Dr. Mattias Alveteg Department of Chemical Engineering II Lund Univer
https://www.lumes.lu.se/sites/lumes.lu.se/files/traven_luka.pdf - 2026-06-26
This study compares the performance of different models used to assess the local wind near-surface conditions at an agricultural site in Scania, southern Sweden. The methods are: (a) the WASP model (Wind Analysis and Application Program), (b) separate linear regressions of the two wind vector components, (c) a regression model based on vector correlation, and (d) linear regression of scalar wind.
The effects of input data uncertainty on the critical loads and exceedance estimates for Swedish forest soils was assessed using Monte Carlo simulations of the PROFILE model. The study focuses on the effects of data uncertainty on the 5%-ile critical load at 150 × 150 km resolution and the 95%-ile exceedance at 150 × 150 km and 50 × 50 km resolution. The results indicate that data uncertainty limi
Background and Aims Organisms may be polymorphic within natural populations, but often the significance and genetic background to such polymorphism is not known. To understand the colour polymorphism expressed in the diploid marsh-orchids Dactylorhiza incarnata, morphological, habitat and genetic differentiation was studied in mixed populations on the island of Gotland, supplemented with genetic m
Sammanfattning Inom konkurrensrätten är kartellbildning väldigt allvarligt och det finns därför ett förbud mot detta vilket är konkurrenslagstiftningens allra viktigaste bestämmelse. Stadgandet finns dels inom EU-rätten, dels i svensk rätt och de ser i stora drag likadana ut. I takt med att EU utvecklat sitt program för att bekämpa kartellbildning har Sverige påverkats att ha ett mer EU-harmonisAbstract Within competition law, cartels are defined as a very serious and infringement and are prohibited. This ban exists both within EU law and in Swedish law and looks largely the same. As the EU has developed their program to combat cartels, Sweden has been affected to have a more harmonized EU system when it comes to combating these types of anti-competitive collaborations. Leniency system
Pentaklorfenol (PCP) är en klorerad aromatisk förening som användes flitigt för att behandla trä mot mikrobiell nedbrytning innan den blev förbjuden på 70-talet. På grund av dess höga löslighet förekommer PCP som en grundvattenförorening kring äldre sågverk. Hjortsberga i södra Sverige är ett exempel på denna typ av förorening och är det område som undersöks i arbetet. Förorenat grundvatten spridsPentachlorophenol (PCP) is a chlorinated aromatic compound that was commonly used for treatment of wood against microbial degradation before it got banned in the 1970s. Due to its solubility in water, PCP is a common groundwater contaminant around old sawmills, for example near Hjortsberga in southern Sweden where this study was performed.. The contaminated groundwater is spreading and leaking int
Pheromone-based monitoring could be a very efficient method to assess the conservation status of rare and elusive insect species, but there are still few studies for which pheromone traps have been used to obtain information on presence, abundance, phenology and movements of such insects. We performed a mark-recapture study of two threatened saproxylic beetles, Osmoderma eremita (Scarabaeidae) and
Naturliga metanutsläpp sker från våra våtmarker världen över. Metan produceras naturligt genom nedbrytning i de syrefria förhållanden som en våtmark erbjuder. För att bättre kunna modellera och skala upp hur mycker metan som faktiskt släpps ut från dessa våtmarker måste ytterligare förståelse skapas över varför metanutsläppen varierar så kraftigt både i tid och rum. Denna studie försöker öka förstMethane emissions from natural wetlands are an important contributor to methane levels in the atmosphere. These emissions are highly variable in time and space, even within sites. Further understanding of this variation is vital to successfully model the overall methane emissions from wetlands. This study investigates spatial variation through measurements of 22 plots across Fäjemyr bog. Manual me
With the sustainable potential of the city as a starting point, this thesis examines brownfield redevelopment in an existing urban context. The Nørrebro neighborhood of Copenhagen serves as a case. The focus is on learning from and reinterpreting existing urban structure, hierarchy, density and scale. Legislation allowing car free development at the chosen site, Vingelodden, also prompts explorati
Collecting detailed hydrogeological data before, during, and after remediation campaigns is essential for effective management and monitoring of contaminated sites. As in-situ remediation injection treatment becomes more popular, recording the hydraulic response during these events offers an opportunity to collect detailed data on hydrogeological parameters. Often, multiple injections are performe
