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A comparison of different orthogonal techniques for the investigation of the conformational stability of NIST mAb in liquid formulations

Antikroppar har ett brett användningsområde med stor potential men det är svårt att skapa stabila lösningar. Den strukturella stabiliteten är en viktig faktor när man väljer läkemedelskandidater, och i de tidiga utvecklingsstadierna görs prediktiva undersökningar för att ta reda på varje kandidats stabilitet och utvecklings-potential. Därmed är det av största intresse att utvärdera hur antikropparA great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. The stability of the candidates can be estimated using different orthogonal techniques and the aim of this investigation was thus to use orthogonal techniques for the investigation of conformationa

Effects of chronic citalopram treatment on central and peripheral spontaneous open-field behaviours in rats

The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and t

Selection on the joint actions of pairs leads to divergent adaptation and coadaptation of care-giving parents during pre-hatching care

The joint actions of animals in partnerships or social groups evolve under both natural selection from the wider environment and social selection imposed by other members of the pair or group. We used experimental evolution to investigate how jointly expressed actions evolve upon exposure to a new environmental challenge. Our work focused on the evolution of carrion nest preparation by pairs of bu

Self-reported versus professionally assessed functional limitations in community-dwelling very old individuals.

The objective of this study was to examine the relationship between self-reported and professionally assessed functional limitations in community-dwelling very old individuals. In total, 306 single-living adults aged 81-90 years were included in this cross-sectional study. The main outcome measure was the presence and absence of self-reported and professionally assessed functional limitations. A s

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Abstract in French Beaucoup d’hommes et de femmes aymara affirment que le savoir humain, transmis par la langue, n’est qu’un pur ‘siwsawi’, i.e. des paroles, des opinions, des points de vue, des jugements d’individus particuliers. Ainsi, il s’agit d’un savoir particulier ; c’est une connaissance concernant l’opinion de certaines personnes, rien de plus. Ceci est, de manière significative, différenMany Aymara men and women claim that human knowledge as transmitted through language is pure ‘siwsawi’, i.e. talk, opinions, views and judgments of particular individuals. As such it is knowledge of a particular kind; it is knowledge concerning the opinions of other humans, nothing else. It is thereby significantly different from the non-linguistic, experiential knowledge that is lived-through and

Utvc12 fall 20160610 1

BIDS UTVC12 Lectures and seminars 2016. Schedule 2016-06-10 Date Time Room Theme Activity Group Teacher Module 1: Course Introduction 1/11 15:00-17:00 111 Course introduction Intro 1/1 AF Issues in contemporary development: The quest for growth and the internationalization of development 4/11 10:00-12:00 MA3 The Elusive Quest for Growth Lec 1/1 MF 9/11 13:00-15:00 111 The Elusive Quest for Growth

https://www.keg.lu.se/en/sites/keg.lu.se.en/files/utvc12_fall_20160610_1.pdf - 2026-05-17

The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse

The high-molecular-mass salivary mucin MG1, one of two major mucins produced by human salivary glands, plays an important role in oral health by coating the tooth surface and by acting as a bacterial receptor. Here this mucin was purified from the submandibular/sublingual saliva of a blood group O individual. The presence of MUC5B as the major mucin in this preparation was confirmed by amino acid

Handkirurgi och dess specifika omvayrdnad

Handkirurgi och dess specifika omvårdnad U PP D R A G SU TB IL D N IN G Institutionen för hälsovetenskaper erbjuder utbildningar som genomförs av lärare vid Lunds universitet och i många fall i samarbete med arbetslivet - en garanti för både ämnesmässig bredd och aktualitet, ett vetenskapligt djup och en modern pedagogik. Institutionens uppdragsverksamhet sker i samarbete med Lund University Commi

https://www.medicin.lu.se/sites/medicin.lu.se/files/handkirurgi_och_dess_specifika_omvayrdnad.pdf - 2026-05-17