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doi:10.1016/j.yexcr.2006.12.014 Research Article Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells Elin K.I. Anderssona,b, Dwain K. Irvina,c, Jessica Ahlsiöa, Malin Parmara,b,⁎ aWallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, S-221 84 Lund, Sweden bLund Strategic Center for Stem Cell Biology and
dc120111_pap 1..5 Performance of HbA1c as an Early Diagnostic Indicator of Type 1 Diabetes in Children and Youth KENDRA VEHIK, PHD 1 DAVID CUTHBERTSON, MS 1 DAVID BOULWARE, MS 1 CRAIG A. BEAM, PHD 1 HENRY RODRIGUEZ, MD 2 LAURENT LEGAULT, MD 3 MILA HYYTINEN, PHD 4 MARIAN J. REWERS, MD, PHD 5 DESMOND A. SCHATZ, MD 6 JEFFREY P. KRISCHER, PHD 1 THE TEDDY, TRIGR, DIABETES PREVENTION TRIAL-TYPE 1, AND T
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/20%2006032016_679_20_Vehik_Diab%20Care_2012.pdf - 2026-05-19
Conventional agriculture, dominated by annual crops, has revolutionised food production but also introduced significant environmental and social challenges. Perennial crops offer a promising alternative, with potential benefits for ecosystem services, agricultural sustainability, and food security. Although the environmental benefits of perennial crops, such as the intermediate wheat grass Kernza
The main focus of this case study was to assess ecological succession and restoration success after the removal of Rosa rugosa. Plant species composition and moss presence, bare ground cover, and biodiversity indices were analysed to identify patterns and differences within and between the restored and an invaded adjacent area. The complete absence of R. rugosa in restored plots confirms the effec
Study Region 103 FLUXNET2015 flux towers distributed across diverse climatic and ecological regions. Study Focus Accurate estimation of evapotranspiration (ET) is critical for understanding regional ecohydrological processes. Physically based models such as the Penman-Monteith-Leuning (PML) model are robust but often constrained by fixed parameterization schemes, while data-driven approaches such
Old-growth forests uniquely support biodiversity while serving as some of the planet's most important carbon stocks. The influence of tree and stand age on carbon flux dynamics remains debated—an urgent question as climate-driven disturbances may reshape forest age structures and in situ carbon storage. To clarify these relationships in Fagus sylvatica , systems, we examined a unique dataset of 3,
The ATLAS Computing Model embraces the Grid paradigm and a high degree of decentralization and sharing of computing resources. The required level of computing resources means that off-site facilities will be vital to the operation of ATLAS in a way that was not the case for previous CERN-based experiments. The primary event processing occurs at CERN in a Tier-0 facility. The RAW data is archived
Popular Abstract in Swedish Allt liv på jorden är beroende av energi. Växter och vissa bakterier kan fånga och utnyttja solens energi för att bygga upp sina celler och dess delkomponenter som fetter, sockerarter och proteiner. Den energi som på så sätt blir bunden i dessa molekyler kan användas av djur och människor genom att vi konsumerar dem. För att energin skall kunna utnyttjas av kroppen måstSepsis is a devastating disease that is caused by the host’s response to an overwhelming infectious process. As sepsis progresses, organs distant from the site of infection become affected and sepsis-induced multiple organ failure ensues. An impaired immunologic response, including dysfunctional peripheral blood immune cells has been described as part of the septic syndrome. Mitochondrial dysfunct
Estimates of relevant source area of pollen (RSAP) and relative pollen productivity (PPE) are critical parameters for quantitative reconstructions of past vegetation and land cover. This study provides estimates for PPE relative to Poaceae for ten taxa, characterizing the cultural landscape of south Estonia and the RSAP for 40 lakes with an average radius of approximately 100 m (22-274 m, average
The long-term carbon storage capacity of the boreal forest is under threat from the increasing frequency and intensity of wildfires. In addition to the direct carbon emissions during a fire, the burnt forest often turns into a net carbon emitter after fire, leading to large additional losses of carbon over several years. Understanding how quickly forests recover after a fire is therefore vital to
Climate change and land-use change represent a dual threat to terrestrial ecosystem functioning. In the tropics, forest conversion to agriculture is occurring alongside warming and more pronounced periods of drought. Rainfall after drought induces enormous dynamics in microbial growth (potential soil carbon storage) and respiration (determining carbon loss), affecting the ecosystem carbon budget.
Accurate evapotranspiration (ET) data are required for many hydro-meteorological applications. Compared with the traditional evaluation that requires in-situ measurements, the triple collocation (TC) technique estimates geophysical product errors without the need for ground truth, which is especially suitable over large areas lacking a dense in-situ network. However, violations of the zero-error c
Background: The Hawthorne Effect is the change in behaviour by subjects due to their awareness of being observed and is evident in both research and clinical settings as a result of various forms of observation. When the Hawthorne effect exists, it is short-lived, and likely leads to increased productivity, compliance, or adherence to standard protocols. This study is a qualitative component of an
The regional variability in tundra and boreal carbon dioxide (CO2) fluxes can be high, complicating efforts to quantify sink-source patterns across the entire region. Statistical models are increasingly used to predict (i.e., upscale) CO2 fluxes across large spatial domains, but the reliability of different modeling techniques, each with different specifications and assumptions, has not been asses
Compared to the well-known drivers of spatial variability in gross primary productivity (GPP), the relative importance of climatic variables, soil properties and plant traits to the spatial variability in net ecosystem exchange of CO2 between terrestrial ecosystem and atmosphere (NEE) is poorly understood. We used principal component regression to analyze data from 147 eddy flux sites to disentang
The crop drought risk assessment is an important basis for mitigating the effects of drought on crops. The study of drought using crop growth models is an integral part of agricultural drought risk research. The current Decision Support System for Agrotechnology Transfer (DSSAT) model is not sufficiently sensitive to moisture parameters when performing simulations, and most studies that conduct di
Background: A warmer climate has consequences for the timing of phenological events, as temperature is a key factor controlling plant development and flowering. In this study, we analyse the effects of the long-term climate change and an extreme weather event on the first flowering day (FFD) of five spring-flowering wild plant species in the United Kingdom. Citizen science data from the UK Woodlan
Assessing status of natural resources and ecosystem components is pivotal for management, where indicators or indices often are used as proxies of ecological state. Many indicators, however, lack reference points and are associated with sampling errors and environmental noise, limiting their usefulness in management. Here we present a method for assessing state changes in ecological indicator from
The terrestrial carbon cycle is an important component of the global carbon budget due to its large gross exchangefluxes with the atmosphere and their sensitivity to climate change. Terrestrial biosphere models showlarge uncertainties in simulating carbon fluxes, which impact global carbon budget assessments. The land surfacecarbon cycle is tightly controlled by soil moisture through plant physiol
Atmospheric inversions have been used for the past two decades to derive large-scale constraints on the sources and sinks of CO2 into the atmosphere. The development of dense in situ surface observation networks, such as ICOS in Europe, enables in theory inversions at a resolution close to the country scale in Europe. This has led to the development of many regional inversion systems capable of as
