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Objective: Infliximab-treated patients with rheumatoid arthritis (RA) may respond insufficiently due to low serum infliximab (sIFX) levels, caused by anti-drug antibodies (ADAs). However, monitoring of sIFX and ADAs is not routinely implemented, and levels for optimal outcome have not been validated. We searched for predictors for sIFX < 0.2 μg/mL and ADA development in a randomized setting. Metho
The Amazon Basin is a unique region to study atmospheric aerosols, given their relevance for the regional hydrological cycle and the large uncertainty of their sources. Multi-year datasets are crucial when contrasting periods of natural conditions and periods influenced by anthropogenic emissions. In the wet season, biogenic sources and processes prevail, and the Amazonian atmospheric composition
METHODS: This was a multicentre, international, observer-masked, randomised controlled trial of people with diabetes and a hard-to-heal foot ulcer done in 32 specialist diabetic foot clinics in three countries (UK, Denmark, and Sweden). After a 4-week run-in period, those with a reduction in ulcer area of less than 50% were randomly allocated (1:1) by computer-generated, web-based randomisation (b
While surgery is a cornerstone in treatment of peripheral nerve injuries, it is not a comprehensive approach, and outcome is unsatisfactory, especially sensory function. The present aim was to translate recent findings about stem- and progenitor cells to improve regenerative outcome, where the cells have to be autologous, available within the same surgical procedure, and minimally manipulated. Gra
Context. Observational evidence indicates that the orbits of extrasolar planets are more various than the circular and coplanar ones of the solar system. Planet-planet interactions during migration in the protoplanetary disc have been invoked to explain the formation of these eccentric and inclined orbits. However, our companion paper (Paper I) on the planet-disc interactions of highly inclined an
Aims The optimal method of tibial component fixation remains uncertain in total knee arthroplasty (TKA). Hydroxyapatite coatings have been applied to improve bone ingrowth in uncemented designs, but may only coat the directly accessible surface. As peri-apatite (PA) is solution deposited, this may increase the coverage of the implant surface and thereby fixation. We assessed the tibial component f
Background. Several clinical studies have suggested possible increase in cardiovascular risk during and in the first weeks after an acute inflammatory disease. Using influenza vaccine as inflammatory stimulus, we investigated whether arterial endothelial dysfunction could persist beyond the inflammatory state, and whether amplified oxidative modification of low-density lipoprotein (LDL) accompanie
Bostadsrätt är en av de vanligaste boendeformerna i Sverige. Det finns närmare 30 000 aktiva bostadsrättsföreningar och ungefär en miljon bostadsrätter. Under det senaste decenniet har priserna på bostadsrätter tredubblats och många nybyggnationsprojekt har inletts. Att köpa en bostad är för många en av de viktigaste investeringarna i personens liv, inte bara för att det är en stor ekonomisk affärCooperative apartments are one of the most common forms of housing in Sweden. There are closer to 30,000 active tenant owners’ associations and approximately one million cooperative apartments. In the last decade the price of a cooperative apartment has tripled, and many new construction projects have been launched. To buy a home is often one of the most important investments in a person’s life, n
Vigabatrin is an antiepileptic drug that is known to cause visual field defects and retinal dysfunction measured by full-field electroretinography (ff-ERG). Underlying mechanisms have not yet been elucidated. The aims of this thesis were to investigate parameters of vigabatrin treatment; reversibility of visual dysfunction, prevalence of retinal dysfunction in children, role of drug-dose and evalu
Introduction Abdominal aortic aneurysm (AAA) mainly affects elderly men, grows slowly, and carries high mortality if left untreated, as rupture risk increases with larger diameters. AAA is well suited for screening due to its slow progression, long latent phase, reliable diagnostics, and established treatments. The primary aim of this thesis was to assess whether absolute infrarenal aortic diamete
Mechanical properties and rate of ATP breakdown (JATP) have been determined in the chemically skinned guinea-pig taenia coli at 22 degrees C. The influence of varied [Ca2+], [Mg ATP] and muscle length were investigated. The shortening response after a step decrease in force (isotonic quick release) was highly curvilinear in the first 100-200 ms. This effect was shown to be a time-dependent respons
Utbrottet av den globala pandemin våren 2020, inneburit omvälvande förändringar för i stort sett alla människor och verksamheter. Privilegier som fri rörlighet och mötesfrihet har sedan utbrottet bytts ut mot strikta restriktioner i de flesta länder vilket drivit många branscher in i krisläge och därmed förändringsarbete. Fastighetsbranschen är inget undantag. Sedan folkhälsomyndigheten rekommenSince the outbreak of the pandemic early 2020, the world has experienced disruptive change in many of its foundations. Privileges as free movement, the freedom of assembly and simply being able to go to the movies have been replaced by strict local and national policies, limiting humans and companies. The Covid-19 agenda has forced a lot of businesses into crisis mode with transformation as a cons
BACKGROUND: Maintenance of the botanical integrity of cereal kernels and the addition of acetic acid (as vinegar) in the product or meal has been shown to lower the postprandial blood glucose and insulin response and to increase satiety. However, the mechanism behind the benefits of acetic acid on blood glucose and satiety is not clear. We hypothesized that the gastric emptying rate could be invol
Sediments from the only permanent lake on the island of Jan Mayen (71°N, 08°30′W), Lake Nordlaguna (NL), were investigated. The lake, with an area of ∼1 km2, is situated at the foot of the world's northernmost active subaerial volcano and is separated from the sea by a 150–240 m wide beach barrier, which reaches 4–5 m above sea level. Most of the lake is deeper than 25 m, with the deepest part bei
The design and construction of large infrastructure projects require detailed information on subsurface geology and identification of potential risks. Geophysical investigations can provide important information for design and risk assessment provided that the optimal method and interpretation approach is adopted.This work presents results from seismic refraction surveys carried out along a planneThe design and construction of large infrastructure projects require detailed information on subsurface geology and identification of potential risks. Geophysical investigations can provide important information for design and risk assessment provided that the optimal method and interpretation approach is adopted.This work presents results from seismic refraction surveys carried out along a planne
Introduction: Ischemic spinal cord injury (SCI) is a serious complication of complex aortic repair. Prophylactic cerebrospinal fluid (CSF) drainage, used to decrease lumbar cerebrospinal fluid (CSF) pressure, enables monitoring of CSF biomarkers that may aid in detecting impending SCI. We hypothesized that biomarkers, previously evaluated in traumatic SCI and brain injury, would be altered in CSF
Background and Aims: The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during infection and inflammation. We investigated the efficacy of S100A8/A9 blockade as a potential new treatment in SIMD. Methods: The relationship betwee
BACKGROUND: Deregulated lipid metabolism is common in cancer cells and the mevalonate pathway, which synthesizes cholesterol, is central in lipid metabolism. This study aimed to assess statin-induced changes of the intratumoral levels of cholesterol and the expression of the low-density lipoprotein receptor (LDLR) to enhance our understanding of the role of the mevalonate pathway in cancer cholest
In this study, the long-term mortality effects associated with exposure to PM10 (particles with an aerodynamic diameter smaller than or equal to 10 µm), PM2.5 (particles with an aerodynamic diameter smaller than or equal to 2.5 µm), BC (black carbon), and NOx (nitrogen oxides) were analyzed in a cohort in southern Sweden during the period from 1991 to 2016. Participants (those residing in Malmö, S
Background: Infants and toddlers with disabilities follows the same developmental paths as typically developing children, but build individual patterns of achievements in their own pace. Aim: To illustrate development in infants who got opportunities to experience locomotion before the age when they developed the physical abilities to move by rolling, crawling, creeping or walking. Method: Re-anal
