Filtyp
Type 1 Diabetes (T1D) is an immune-mediated disease where the pancreatic beta cells are selectively destroyed by autoreactive CD8+ T cells. However, the triggering events that eventually leads to autoreactive CD8 T cells infiltrating the pancreatic islets and, subsequently, destroying them still needs to be unveiled. Genetic and epidemiological evidence points to a substantial influence of environ
The European Motor Vehicle Industry is complex and plays a significant role in the economic aspects of the common market. The motor vehicles constitute an important part of everyday life for many consumers and are the second largest investment many makes. The legal framework surrounding this industry includes EU's Competition policy, which constitute the third pillar in the Single European Mar
Background: Gallstones affect women more frequently than men, and symptomatic gallstones are increasingly treated with surgical removal of the gallbladder (cholecystectomy). Breast, endometrial, and ovarian cancer share several risk factors with gallstones, including overweight, obesity, and exposure to female sex hormones. We intended to assess the association between chole-cystectomy and female
BACKGROUND & AIMS: Gallstones (cholelithiasis) constitute a major health burden with high costs related to surgical removal of the gallbladder (cholecystectomy), generally indicated for symptomatic gallstones. The association between gallstones and cholecystectomy and kidney cancer is controversial. We comprehensively investigated this association, considering age at cholecystectomy and time f
Background: Celiac disease (CD) is an autoimmune disease leading to gastrointestinal symptoms and mineral deficiencies. The pathogenetic mechanisms, besides the clear HLA association, are elusive. Among environmental factors infections have been proposed. Covid-19 infection results in a systemic inflammatory response that often also involves the gastrointestinal tract. The aim of the present study
Magnetotactic bacteria (MTB) are known to biosynthesise single-domain magnetite (Fe3O4) for geomagnetic navigation and their relict magnetosomes (called magnetofossils) can control the magnetic properties of lake and marine sediments. Magnetotactic bacteria also produce greigite (Fe3S4) magnetosomes but, compared to those made of magnetite, relatively little is known about the sedimentary environm
Background Familial adenomatous polyposis (FAP) is a rare inherited syndrome that predisposes the patient to cancer. Treatment of FAP-related ampullary lesions is challenging and the role of endoscopic papillectomy has not been elucidated. We retrospectively analyzed the outcomes of endoscopic papillectomy in matched cohorts of FAPrelated and sporadic ampullary lesions (SALs). Methods This retrosp
Background and aims: Previous study showed that elevated circulating hepatokine follistatin (FST) associates with an increased risk of type 2 diabetes by inducing adipose tissue insulin resistance. Here we explore further the relationships between plasma FST levels with mortality and health outcomes. Methods and results: The population-based Malmö Diet Cancer cardiovascular cohort (n = 4733, age 4
Objective: To estimate the cost-effectiveness of strategies to prevent spontaneous preterm delivery (PTD) in asymptomatic singleton pregnancies, using prevalence and healthcare cost data from the Swedish healthcare context. Methods: We designed a decision analytic model based on the Swedish CERVIX study to estimate the cost-effectiveness of strategies to prevent spontaneous PTD in asymptomatic wom
Avhandlingen bidrar med kunskap inom fältet tidiga interventioner och tidigasamordnade insatser, i synnerhet inom skolsocialt arbete. I en systematisköversikt undersöks vilka studier som utförts av videofeedbackinterventioner(VF) mellan 1990 och 2014 och om de haft önskad effekt. I likhet med tidigareforskning visar den att VF kan påverka föräldrars och pedagogers samspel medbarn i positiv riktninThe dissertation concerns video feedback interventions (VF) aimed at interactions between parents, teachers and children, more specifically children who display disruptive behaviour problems (DBP) in school. To counteract early social exclusion, the dissertation emphasises the importance of fostering change processes, where parents and teachers in preschool and school play a significant role in su
AimPeak oxygen uptake (VO2peak) is closely related to total heart volume (THV) in healthy individuals. This study aimed to investigate 1) the association between VO2peak and THV in subjects with subclinical diastolic dysfunction, athletes, healthy controls, and patients with established heart failure with and without preserved ejection fraction (HFpEF, HFrEF), and 2) whether VO2peak/THV-index can
INTRODUCTION: This study examined trends in socioeconomic inequalities in obesity among Portuguese women and men using data from National Health Surveys (NHSs).METHODS: We analysed weighted data from adults aged 20-64 years from the 1998/1999 (n = 20,581), 2005/2006 (n = 13,088), 2014 (n = 7284), and 2019 (n = 5959) NHSs. Obesity was defined as body mass index (BMI) ≥30 kg/m 2, based on self-repo
Background: Neuroimaging with magnetic resonance imaging (MRI) may assist clinicians in evaluating brain injury and optimising care in comatose adults resuscitated after out-of-hospital cardiac arrest (OHCA). However, contemporary international data on its use are lacking. Aim: The primary aim was to compare the patient characteristics, early postresuscitation care, and neurological outcomes of pa
BACKGROUND: The cross-sectional association between cerebral tissue oxygen saturation (SctO 2) and heart failure (HF) has been previously studied, but the prognostic significance of SctO 2 in HF remains uncertain. This study aimed to assess the role of SctO 2 as a risk factor for all-cause mortality and rehospitalisation, as well as to explore the cross-sectional association between physical ac
Purpose: Diffusion MRI probes tissue microstructure, but low SNR and limited resolution hinder detection of features and parameter estimates. We introduce slice excitation with random overlap (SERO), which enables variable repetition times (TRs) and diffusion weighting within a single shot. This acquisition supports super-resolution reconstruction of baseline signal ((Formula presented.)), diffusi
Background: Road-traffic noise may influence the development of cardiovascular events such as stroke and myocardial infarction, but etiological mechanisms remain unclear. This study aimed to assess the relationship between long-term road-traffic noise exposure and coronary atherosclerosis in Sweden. Methods: In the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort, including 30,154 subjects a
Popular AbstractStörre kriser och katastrofer som stormen Gudrun och dess konsekvenser är sannolikt att vänta i framtiden. Det råder dock ovisshet om vilka kriserna kommer att vara och under vilka förutsättningar. Nya och kompletterande vetenskapliga studier och metoder inom kris- och katastrofforskningen måste till för att öka samhällets kunskap om och förmåga att hantera kända och okända hotbildSevere crises and disasters such as the Hurricane Gudrun and their consequences will probably occur in the future. However, there are many uncertainties concerning disasters and their effects. New scientific approaches and methods for crisis and disaster research must be developed to increase the knowledge and ability of societies to manage known and unknown threats. Substantial research on the em
Adherence to antiretroviral therapy is a global problem among adolescents living with human immunodeficiency viruses (HIV), and it is associated with treatment failure and the development of viral resistance. One of the most significant barriers to treatment adherence among adolescents is forgetting to take drugs as prescribed. One of the key strategies recommended to improve this problem is the u
Background: There has been a notable decrease in antibiotic prescribing in the last thirty years in Sweden. Little is known about factors influencing antibiotic prescribing over several years. Objective: To compare primary care physicians who, over time, reduced their antibiotic prescribing for respiratory tract infections with those who remained either high or low prescribers regarding potentiall
ObjectiveTo provide the most up-to-date data on the burden of malignant mesothelioma (MM) and the projections through 2029 in China.MethodsData on patients diagnosed with MM from China during 1990-2019 were obtained from the Global Burden of Disease (GBD) 2019 database, including annual cases and deaths data and age-standardized rates of incidence, mortality, and disability-adjusted life-years (DA
