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Purpose: Gene therapy for RPE65 retinopathy has been recently approved. The purpose of this study was to assess retinal structure and function in 3 siblings presenting with late-stage RPE65 retinopathy and to assess the unmet need for such therapy in Saudi Arabia. Methods: Search of the retinal dystrophy registry at King Khaled Eye Specialist Hospital and clinical examination including multimodal
As the need of environmentally friendly alternatives to fossil fuels is growing bigger, so is the need for knowledge and research around possible new raw materials that could serve that pur-pose. One discussed product is biogas. Since biogas can be produced from not only food waste and wastewater residue, but from any substrate that contains fats, proteins and/or car-bohydrates, with the help of d
Background: The Construction sector is globally one of the most resource-intensive sectors that accounts for significant material consumption and waste generation. Approximately 10% of Sweden’s construction and demolition waste consists of material waste. Alongside this 30 -35% of the total production costs are linked to waste and spillage. Purpose and research questions: The study aims to analy
With the ever increasing demand for higher data rates and reliability, efficient management of cellular networks remains a challenge. Among other technologies, fifth generation systems are expected to tackle this challenge using large electronically controllable antenna arrays operating in the time division duplex mode. In such systems, spatial beamforming is implemented with accurate channel esti
We have recently described frequency-dependent effects of mobile phone microwaves (MWs) of global system for mobile communication (GSM) on human lymphocytes from persons reporting hypersensitivity to electromagnetic fields and healthy persons. Contrary to GSM, universal global telecommunications system (UMTS) mobile phones emit wide-band MW signals. Hypothetically, UMTS MWs may result in higher bi
Objectives: To quantify the influence of lifestyle factors on tumour necrosis factor inhibitor (TNFi) treatment response, in axial spondyloarthritis (axSpA). Methods: Data on biologics-naïve adults with axSpA were captured from European rheumatology registries. Information on lifestyle factors (smoking, overweight/obesity, and/or alcohol consumption) were identified ± 30 days of commencing their f
Background/Objectives: Intraoperative frozen biopsies are essential during surgery for Hirschsprung’s disease (HD). However, this method has several limitations with the need for a faster and real-time diagnostic alternative. For this, consistent histoanatomical and morphometric differences between aganglionic and ganglionic bowel must be established. The primary objective was to compare dimension
Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cance
Background: Dairy proteins, in particular the whey fraction, exert insulinogenic properties and facilitate glycemic regulation through a mechanism involving elevation of certain plasma amino acids, and stimulation of incretins. Human milk is rich in whey protein and has not been investigated in this respect. Method: Nine healthy volunteers were served test meals consisting of human milk, bovine mi
Title: The Irreverent Paradox: Young adult consumers' perceptions of an irreverent tone on brands' social media Seminar date: May 30th 2024 Course: FEKH29, Degree Project Undergraduate level in marketing, 15 UPC Authors: Joel Baumann & Douglas Cederlund Advisor/s: Nikos Macheridis Key words: Social media marketing; Tone of voice; Irreverence; Consumer experiences; Authenticity Research
This degree project aimed to produce a standardized food product enriched with 14g polar lipids (PL) and compare its effects on glycemic response and appetite sensations both acutely and following a second meal in healthy individuals. In order to elucidate the viability of enriching a prebaked product with polar lipids researchers spent multiple weeks assessing variations in recipe, cook time, coo
This report presents the work developing a modular sailboat interior system that offers an easy and affordable way for recreational sailors to customize the interiors of their sailboats according to their different and changing needs. Cruising sailboats are like floating houses or cottages, with the difference that the interior is permanent. They have a long product life and often last for decade
When installing new research equipment at the synchrotron research laboratory MAX IV, a final positional accuracy of tens of microns is usually needed. To obtain that accuracy, initial reference points must be placed within 2 mm from the nominal target points in CAD, in a process referred to as bluelining. It is currently a manual process where points from a virtual environment are transferred to
BACKGROUND: Long COVID and cardiovascular autonomic dysfunction, including postural orthostatic tachycardia syndrome (POTS), present significant healthcare challenges. Long-term monitoring is challenging due to the evolving nature of symptoms and the limited availability of objective diagnostic tools. With over 200 million electrocardiogram (ECG)-enabled smartwatches sold worldwide, these devices
Introduction: Monitoring replacement therapy with standard and extended half-life (EHL) products is challenging, since one-stage assay (OSA) and chromogenic substrate assay (CSA) results may differ significantly. Recent recommendations include local validation of each new product with recovery within 20–30%, depending on activity level. Aim: To validate factor VIII (FVIII) activity for monitoring
BACKGROUND: Neurointensive care is moving toward more automated patient management. This study aimed to evaluate a novel external ventricular drainage (EVD) system, the VGuard® system, as a tool for intracranial pressure (ICP) monitoring and automating ventricular drainage of cerebrospinal fluid (CSF), focusing on its safety and potential to reduce complications associated with manual EVD manageme
OBJECTIVE: Explore women's subjective perceptions of healing from perineal tears in childbirth, with a particular focus on infection-related symptoms.METHODS: Women enrolled in a randomized-controlled-trial (ClinicalTrials, NCT02863874) were invited to complete a questionnaire at one- and eight-weeks postpartum. Infection-diagnosis was obtained separately through medical records.RESULTS: 1462 wome
Objectives The aim of this study was to conduct a nationwide all comer description of incidence, contemporary management and outcome in Swedish spontaneous coronary artery dissection (SCAD) patients. The incidence of SCAD as well as the management and outcome of these patients is not well described. Design A nationwide observational study. Participants and setting All patients with SCAD registered
Background Despite well-established guidelines for managing major depressive disorder, its extensive disability burden persists. This Value of Treatment mission from the European Brain Council aimed to elucidate the nature and extent of gaps between best-practice and current-practice care, specifically to: 1. Identify current treatment gaps along the care pathway and determine the extent of these
Background: Continuous glucose monitor (CGM) devices enable characterization of individuals' glycemic variation. However, there are concerns about their reliability for categorizing glycemic responses to foods that would limit their potential application in personalized nutrition recommendations. Objectives: We aimed to evaluate the concordance of 2 simultaneously worn CGM devices in measuring pos
