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Background: The International Consortium for Health Outcomes Measurement (ICHOM) was founded in 2012 to propose consensus-based measurement tools and documentation for different conditions and populations.This article describes how the ICHOM Older Person Working Group followed a consensus-driven modified Delphi technique to develop multiple global outcome measures in older persons. The standard se
Accumulation of damaged or misfolded proteins resulted from oxidative protein modification induces endoplasmic reticulum (ER) stress by activating the pathways of unfolded protein response. In pathologic hemolytic conditions, extracellular free hemoglobin is submitted to rapid oxidation causing heme release. Resident cells of atherosclerotic lesions, after intraplaque hemorrhage, are exposed to he
Pericardial adhesions after cardiac operations are a widely known phenomenon. They may severely complicate reoperations, making reentry hazardous, increasing bleeding, and prolonging the operation time. The anatomic orientation and visibility of both bypass grafts and coronary arteries are also impaired. With the aim of minimizing pericardial adhesions after cardiac operations, we studied the cour
The purpose of this article is to analyse quality attributes of regional public transport and their influence on modal choice, demand, and customer satisfaction through a literature review. The review is based on a working definition of regional public transport with boundaries toward local as well as interregional public transport: Regional public transport (i) targets passengers travelling betwe
We reconstructed a record of the micrometeorite flux in the Late Cretaceous using the distribution of extraterrestrial spinel grains across an ~2 m.y. interval of elevated 3He in the Turonian Stage (ca. 92–90 Ma). From ~30 m of the limestone succession in the Bottaccione section, Italy, a total of 979 kg of rock from levels below and within the 3He excursion yielded 603 spinel grains (32–355 µm si
Corynebacterium is a genus that can contaminate blood cultures and also cause severe infections like infective endocarditis (IE). Our purpose was to investigate microbiological and clinical features associated with contamination and true infection. A retrospective population-based study of Corynebacterium bacteremia 2012–2017 in southern Sweden was performed. Corynebacterium isolates were species
PURPOSE: A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour.METHODS: We id
Introduction: When a child is diagnosed with Type 1 diabetes, it involves extensive lifestyle changes for the whole family. There is limited knowledge of the impact the initial care has for children and parents over time. The aim was to compare children’s diabetes-specific health-related quality of life (HRQOL) in hospital-based care and hospital-based home care (HBHC), 12 and 24 months after the
More than 50 irregular satellites revolve around Jupiter and more than 30 around Saturn. There, at least three collisional families were identified. Among these, the Himalia family of prograde irregular moons at Jupiter is characterised by a velocity dispersion of several hundred m/s, inconsistent with a collisional origin (Nesvorný et al., 2003). Here we investigate whether the dispersion could s
Despite emergency and essential surgery and anaesthesia care being recognised as a part of Universal Health Coverage, 5 billion people worldwide lack access to safe, timely and affordable surgery and anaesthesia care. In Tanzania, 19% of all deaths and 17 % of disability-adjusted life years are attributable to conditions amenable to surgery. It is recommended that countries develop and implement N
A preferential incorporation of dietary arachidonic acid (20:4, n-6) into chyle lipoprotein phospholipids, a relative resistance of 20:4 esters of chyle triacylglycerol (TG) to hydrolysis by lipoprotein lipase, a preferential utilization of 20:4 for phospholipid acylation, and a low rate of oxidation of 20:4 are factors that may contribute to the differences seen in the incorporation into tissue l
Diverse and complex interactions as well as multi-actor systems characterise resource use and re- source policy. This makes system analysis a relevant tool to orient resource policy towards the long term. Analysing such complex systems requires systemic thinking, consideration of causal loops as well as time-lags and delays in system responses.In the SimRess project, system analysis encompassed pa
BackgroundOrgan donation guidelines recommend a “clear” conventional bedside chest radiograph before lung transplantation despite only moderate accuracy for cardiopulmonary abnormalities.PurposeTo evaluate the influence of donor image interpretation on lung transplantation outcome in recipients by following early and late complications, one-year survival, and to correlate imaging findings and bloo
Purpose-The purpose of this paper is to address the issue of supply management coordination among a prominent contact lens company (customer), its carton supplier (first tier), and paperboard supplier (second tier). Adopting concepts within the theory of swift and even flow, the authors integrate the physical (material) and information flow among these supply partners to ensure higher productivity
Anthropogenic nitrogen deposition is widely considered to increase CO2 sequestration by land plants on a global scale. Here, we demonstrate that bedrock nitrogen weathering contributes significantly more to nitrogen-carbon interactions than anthropogenic nitrogen deposition. This working hypothesis is based on the introduction of empirical results into a global biogeochemical simulation model over
This overview of progress made in preventing post-traumatic osteoarthritis (PTOA) was delivered in a workshop at the Orthopaedics Research Society Annual Conference in 2019. As joint trauma is a major risk factor for OA, defining the molecular changes within the joint at the time of injury may enable the targeting of biological processes to prevent later disease. Animal models have been used to te
Filamentous fungi play a key role in the terrestrial carbon cycle as they are the primary decomposers of lignocellulose in soil organic matter (SOM). Fungi secrete a wide range of oxidative and hydrolytic enzymes, and generate radicals through extracellular secondary metabolites to decompose SOM. To study fungal decomposition of SOM, the activities of isolated enzymes are typically studied as prox
BACKGROUND: The management of diverticular disease and its complications are an increasing burden to the health system. The natural history of conservatively managed diverticular abscesses (Hinchey I and II) is poorly described and it remains open to debate whether subsequent sigmoid resection is indicated after conservative management. This observational study compares outcomes of patients treate
The length of the growing season for deciduous trees in temperate and boreal forests is determined by the timing of bud burst and autumn senescence. It is generally assumed that a warmer climate leads to a longer growing season due to earlier bud burst and delayed autumn senescence and thereby increased gross primary production (GPP) of forests. In this study, we analysed past (1873–1951) and curr
